Epidemiological and laboratorial profile of patients with isolation of nontuberculous mycobacteria

Pedro, H. S. P.; Coelho, Andréa Gobetti Vieira; Mansur, Isabela Mazuco; Chiou, Carolina A.; Pereira, Maria Izabel Ferreira; Belotti, Naiara Cristina Ule; Ismael, Manuela Galloy Sanches; Cury, Maria Rita de Cássia Oliveira; Nardi, Susilene Maria Tonelli; Chimara, Érica

doi:10.4103/ijmy.ijmy_87_17

Cited by 11 publications

(4 citation statements)

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“…A limitation of the present study is the small number of NTM cases; however, it provided essential data on the clinical and epidemiological profile and treatment of NTM. The current research from Mato Grosso significantly contributes to data on the prevalence and distribution of NTM species isolated in Brazil (Ueki et al, 2005;Pedro et al, 2017;Carneiro et al, 2018).…”

Section: Resultsmentioning

confidence: 99%

Pulmonary mycobacteriosis: clinicalepidemiological profile of patients, treatment management, clinical outcome, and its species in the state of Mato Grosso, Brazil (2013-2020)

Takahara,

De Oliveira,

Dias Hoffmann-Santos

2023

Rev Patol Trop

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This study aimed to describe the clinical-epidemiological profile of patients in the State of Mato Grosso, who were affected by non-tuberculous mycobacteria (NTM), treatment management, clinical outcomes, and the species most commonly isolated from clinical samples. Between 2013 and 2020, the study analyzed 37 medical records from the Health Pulmonology sector of the Reference Center for Medium and High Complexity and it searched the Laboratory Environment Manager (GAL) system of the Central Public Health Laboratory of Mato Grosso. Patients with mycobacteriosis were predominantly diagnosed with MAC complex (avium-intracellulare complex) (n= 23.6%), with an average age of 62 years old; 51.4% were male, Caucasian (62%), and predominantly immunocompetent (HIV-negative). Most patients with comorbidities were older adults, they had sequelae of previous tuberculosis (56.8%), they were smokers (62.2%), and they had a low body mass index (29.7%) due to weight loss. Other patients had bronchiectasis (81.1%) and cavitary lesions (48.6%), with a lower incidence of chronic obstructive pulmonary disease (COPD). The municipalities with the highest rates of nontuberculous mycobacteria were Cuiabá (14 cases), Várzea Grande (five cases), Sinop (two cases), Nova Mutum (two cases), and Rondonópolis (two cases). This study presented data from the region, with a clinical, epidemiological profile, diversity of NTM species, and treatment management according to the patient’s response to the specific treatment of the identified Mycobacterium and various outcomes. KEY WORDS: Non-tuberculous mycobacteria; MAC complex Mycobacterium; comorbidities; tuberculosis; mycobacteriosis.

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Section: Resultsmentioning

confidence: 99%

Pulmonary mycobacteriosis: clinicalepidemiological profile of patients, treatment management, clinical outcome, and its species in the state of Mato Grosso, Brazil (2013-2020)

Takahara,

De Oliveira,

Dias Hoffmann-Santos

2023

Rev Patol Trop

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“…(3) The limitation of M. simiae studies, particularly in the Middle East region, including Iran (11,12,27,34).…”

Section: Discussionmentioning

confidence: 99%

Mycobacterium simiae Isolates Subtypes and Molecular Drug Susceptibility in Iran

Malekshahian

Tabarsi

Farnia

et al. 2022

Arch Clin Infect Dis

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Background: Despite the clinical and epidemiological importance of Mycobacterium simiae worldwide, including in Iran, there is no clear and effective treatment regimen for M. simiae and its different subtypes. Objectives: Concerning the superiority of molecular approaches, this study aims to identify the common M. simiae subtypes submitted to the National Reference Tuberculosis (TB) Laboratory of Iran and study the presence of drug resistance by molecular detection methods. Methods: We included sputum samples with M. simiae confirmation submitted to the National Reference TB Laboratory of Iran from May 2014 to May 2016. The polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay was used for drug susceptibility testing (DST). Results: Among 7200 TB suspected patients, a total of 60 M. simiae cases belonging to subtype I were identified. All the included clinical isolates met the American Thoracic Society (ATS) and Infectious Diseases Society of America (IDSA) diagnostic criteria and were considered the disease’s causative pathogen. Males (58.33%), elderly (68.54%), and patients with a history of TB (51.42%) were shown to be more prone to infection with the disease. All clinical isolates of M. simiae were resistant to rifampin (RIF) and isoniazid (INH). Amikacin/kanamycin (AMK/KAN) and ciprofloxacin (CIP) susceptibility was found to be 91.66% and 88.33%, respectively. Conclusions: Subtype I was exclusively identified among M. simiae patients in Iran. Molecular detection of drug resistance suggests that amikacin/kanamycin and ciprofloxacin could be used to treat patients infected with M. simiae subtype I.

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“…(24) Recent studies conducted in Brazil have reported that M. avium is the NTM species most often isolated from respiratory specimens in HIV-infected patients. (25,26) The present study was carried out at a referral hospital for HIV-infected patients, located in the Brazilian state of Rio Grande do Sul, where the prevalence of HIV infection is 38.3 cases/100,000 population, the second highest among all of the states in the country. (27) Among the patients infected with NTM, most were infected with M. avium (72.0%), and 55.5% of those patients were coinfected with HIV.…”

Section: Discussionmentioning

confidence: 99%

“… 24 Recent studies conducted in Brazil have reported that M. avium is the NTM species most often isolated from respiratory specimens in HIV-infected patients. 25 , 26 …”

Section: Discussionmentioning

confidence: 99%

Nontuberculous mycobacteria in patients with suspected tuberculosis and the genetic diversity of Mycobacterium avium in the extreme south of Brazil

Busatto¹,

Vianna²,

Silva³

et al. 2020

J Bras Pneumol.

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Objective: Nontuberculous mycobacteria (NTM) are a heterogeneous group of bacteria that are widely distributed in nature and associated with opportunistic infections in humans. The aims of this study were to identify NTM in patients with suspected tuberculosis who presented positive cultures and to evaluate the genetic diversity of strains identified as Mycobacterium avium. Methods: We studied pulmonary and extrapulmonary samples obtained from 1,248 patients. The samples that tested positive on culture and negative for the M. tuberculosis complex by molecular identification techniques were evaluated by detection of the hsp65 and rpoB genes and sequencing of conserved fragments of these genes. All strains identified as M. avium were genotyped using the eight-locus mycobacterial interspersed repetitive unit-variable-number tandem-repeat method. Results: We found that NTM accounted for 25 (7.5%) of the 332 mycobacteria isolated. Of those 25, 18 (72%) were M. avium, 5 (20%) were M. abscessus, 1 (4%) was M. gastri, and 1 (4%) was M. kansasii. The 18 M. avium strains showed high diversity, only two strains being genetically related. Conclusions: These results highlight the need to consider the investigation of NTM in patients with suspected active tuberculosis who present with positive cultures, as well as to evaluate the genetic diversity of M. avium strains.

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Epidemiological and laboratorial profile of patients with isolation of nontuberculous mycobacteria

Cited by 11 publications

References 0 publications

Pulmonary mycobacteriosis: clinicalepidemiological profile of patients, treatment management, clinical outcome, and its species in the state of Mato Grosso, Brazil (2013-2020)

Pulmonary mycobacteriosis: clinicalepidemiological profile of patients, treatment management, clinical outcome, and its species in the state of Mato Grosso, Brazil (2013-2020)

Mycobacterium simiae Isolates Subtypes and Molecular Drug Susceptibility in Iran

Nontuberculous mycobacteria in patients with suspected tuberculosis and the genetic diversity of Mycobacterium avium in the extreme south of Brazil

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