Work-related stress has for many decades remained a major concern Worldwide. In the West Africa region, it is an amplified discussion owing to technological deficit, deficiency of work-relieving physical and social amenities, unemployment and underemployment and corruption. Nurses are health workers involved in the healthcare and management of people. The review was designed to examine various stress-relating risk factors among nurses in West Africa. A literature search was done using Web-based databases like Google Scholar, PubMed, Scopus, and Web of Science. The search was done using several terms and text words. Increased workload, hazard exposure, shortage of staff, poor incentives, poor patient attitude, increased length and frequency of duty, shortage of resources and equipment, work environment, high energy involvement and limited opportunity for professional advancement were risk factors for work-related stress among nurses in West Africa. The most predominant risk factor was increased workload followed by shortage of equipment and resources.