Epidemiological aspects of hepatitis C virus infection among HIV-infected individuals in Mato Grosso State, Central Brazil

Mussi, Aparecida Duarte Hg; Pereira, Rui Alberto Roldão de Almeida; Silva, Vergínia de Azevedo Corrêa e; Martins, Regina Maria Bringel; Souto, Francisco José Dutra

doi:10.1016/j.actatropica.2007.08.001

Cited by 9 publications

(14 citation statements)

References 25 publications

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“…Similar results were described with percentages close to 50% detection of HCV RNA in anti-HCV-positive samples in other studies in Brazil. 16,17 In contrast, HCV RNA was detected in approximately 90% of HIV-positive individuals who had never been treated for HCV 13 in the South region. The variations in the proportion of HCV RNA detection in anti-HCV samples in different studies probably reflect methodological differences, which include the degree of exposure to antiretroviral drugs in different population groups.…”

Section: Discussionmentioning

confidence: 98%

“…2,3 Genotype 3 and subtype 1a have been associated with transmission in IDUs. 16,17,20 The presence of genotype 3 in the population studied could indicate the importance of injectable drugs for HCV transmission in HIV-infected patients. However, the study was not designed to analyze the association between genotypes and the HCV transmission route.…”

Section: Discussionmentioning

confidence: 99%

“…The predominance of genotype 1 is consistent with results obtained in various studies conducted in Brazil. 13,16,18,19 Genotype 1 has a worse therapeutic response than genotypes 2 and 3. 2,3 Genotype 3 and subtype 1a have been associated with transmission in IDUs.…”

Section: Discussionmentioning

confidence: 99%

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Prevalence of hepatitis B and C infection and associated factors in people living with HIV in Midwestern Brazil

Brandao

Pfrimer

Martelli

et al. 2015

The Brazilian Journal of Infectious Diseases

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This study aimed to estimate the prevalence of infection by the hepatitis B virus (HBV) and hepatitis C virus (HCV) in people infected by the human immunodeficiency virus (HIV) and analyze sociodemographic and behavioral factors associated with such co-infection. A cross-section study was performed in 495 individuals treated at a public center in the city of Goiânia. Participants were interviewed and blood collected for evaluation of serological and molecular markers for HBV and HCV. The rate of exposure to HBV was 33.5% (95% CI 29.4-37.9). Nineteen patients (3.8%) were diagnosed as HBV carriers, of whom 68.4% were HBV DNA positive. The prevalence of anti-HCV was 9.7% (95% CI 7.3-12.7). Genotype 1a was identified in 72.7% of the PCR samples positive for HCV. Co-infection by all three viruses was 4.4% (95% CI 2.9-6.8). Being, male, aged ≥40 years, history of sexually transmitted disease (STD), and having homosexual practices were independently associated with the presence of markers of HBV exposure. A history of injectable drugs use and STDs showed association with HCV seropositivity. Approximately 50% of participants were not aware of their HBV and HCV serostatus. The results obtained may contribute to assess the burden of viral hepatitis in people living with HIV and to guiding preventive measures for more vulnerable groups.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

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Prevalence of hepatitis B and C infection and associated factors in people living with HIV in Midwestern Brazil

Brandao

Pfrimer

Martelli

et al. 2015

The Brazilian Journal of Infectious Diseases

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“…However, antibody to HCV (anti-HCV) persists. HCV is cleared spontaneously in approximately 26% of acute infections according to NHANES III data, but reported rates differ (0-42%) depending on the study population [2][3][4][5][6][7][8][9][10][11][12][13][14][15]. Since HCV and human immunodeficiency virus (HIV) share epidemiological factors, HCV screening is recommended in the HIV population, making their medical records an ideal resource for the evaluation of spontaneous clearance of HCV.…”

Section: Introductionmentioning

confidence: 99%

Sexual transmission is associated with spontaneous HCV clearance in HIV-infected patients

Shores

Maida

Soriano³

et al. 2008

Journal of Hepatology

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“…1 In the United States and Europe, it is estimated that approximately 30% of HIV patients are co-infected with HCV, 17 which may reach up to 95% if one considers blood as the route of transmission, both IDU as well as blood transfusion. 20 In Brazil, the prevalence varies from 5 to 54% depending on the region investigated and the study design, [21][22][23][24][25][26] and may reach 84% in IDU. 21,27 In this study, we observed a preva- 28 but lower than that observed in patients in Londrina (PR) by Reich et al 29 (21%) and in Santa Maria (RS) by Santos et al 30 (31.2%).…”

Section: Discussionmentioning

confidence: 99%

Seroprevalence of HCV markers among HIV infected patients from Curitiba and metropolitan region

Tizzot

Grisbach²,

Beltrame

et al. 2016

Rev. Assoc. Med. Bras.

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Results: a total of 12.9% of HIV+ patients were positive for anti-HCV antibodies, 64.1% were men and 35.9% women, with mean age of 44.5 years (24-66). The frequency of HCV among men was 16.7% and among women 9.1% (p=0.06). HCV prevalence was associated to HIV infection when compared to the general population (p<10 -6 , OR=100.4; 95CI=13.7-734.9). The parenteral route of transmission was the most frequent among coinfected patients (46.1%), and the sexual transmission among HIV+/HCV-(71.8%) (p=0.02, OR=0.2; 95CI=0.1-0.7). The frequency of intravenous drug users was higher among the coinfected patients (61.5%) compared to the non coinfected (12.6%) (p<10 -6 , OR=11.1; 95CI=4.5-27.7). Conclusion: the prevalence of coinfection with HCV in HIV+ patients is 12.9%, 88 times higher than in the general population in Curitiba. The most frequent route of transmission in the coinfected patients is parenteral, but the sexual route is also representative (34.6%).

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Epidemiological aspects of hepatitis C virus infection among HIV-infected individuals in Mato Grosso State, Central Brazil

Cited by 9 publications

References 25 publications

Prevalence of hepatitis B and C infection and associated factors in people living with HIV in Midwestern Brazil

Prevalence of hepatitis B and C infection and associated factors in people living with HIV in Midwestern Brazil

Sexual transmission is associated with spontaneous HCV clearance in HIV-infected patients

Seroprevalence of HCV markers among HIV infected patients from Curitiba and metropolitan region

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