Epidemiological aspects of spontaneously acquired vaccinia in the rabbit

Pearce, Louise; Rosahn, Paul D.; Hu, Chenchen

doi:10.1002/path.1700430208

Cited by 4 publications

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“…Three pox immune sera were tested, two from experimental cases obtained 31 and 33 days after inoculation and one from a spontaneous case obtained approximately a month after clinical signs had healed. The virus employed was derived from the 8th, 10th, and lSth serial rabbit passage of the Xyl71 strain (2). A total of 28 pox immune serum-pox virus mixtures were tested on 6 rabbits.…”

Section: Resultsmentioning

confidence: 99%

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Studies on the Etiology of Rabbit Pox

Rosahn

Pearce

1936

Journal of Experimental Medicine

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The preceding paper contains the results of various reinoculation experiments in which the viruses of rabbit pox, virus I I I disease, infectious m y x o m a of rabbits, culture (dermo) vaccinia, and neurovaccinia were compared (1). The findings with respect to the reaction of recovered rabbits to exposure to clinical cases of pox, together with the observations on a calf inoculated with pox, two specimens of vaccine virus, and neurovaccine were also reported. The present paper is concerned with the results of the serum neutralization tests in which various combinations of the viruses and the immune sera of pox, vaccinia, neurovaccinia, and virus I I I were studied. Materials and MethodsThe various virus emulsions were prepared from tissues obtained from cases of acute orchitis produced by intratesticular injection of tissue-virus. The testicles were ground with alundum and Locke's solution to make a suspension of 10 to 20 per cent concentration by weight. Gross particles were removed by low speed centrifugation. The emulsions were kept in the ice box while their bacterial sterility was tested.The immune sera were obtained from rabbits inoculated 17 to 134 days previously or in the case of spontaneous pox, a fortnight or more after all signs of the disease had healed. Each specimen was kept in sealed tubes in the ice box. The sterility of each serum was tested before tubing and before use.The tests were carried out in the usual manner. Desired dilutions of virus or serum were made with Locke's solution. Equal parts of tissue-virus emulsion and of serum were thoroughly mixed in small sterile Petri dishes and allowed to stand at room temperature 1½ to 2½ hours; 0.2 cc. of the mixture was then injected 379 on

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Section: Resultsmentioning

confidence: 99%

“…The animals were examined daily. The results were usually limited to the findings of a week on account of the pronounced disease with its marked constitutional symptoms produced by pox virus (2,3).…”

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confidence: 99%

Studies on the Etiology of Rabbit Pox

Rosahn

Pearce

1936

Journal of Experimental Medicine

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“…10 to 15 per cent emulsions by weight were made with Locke's solution by grinding the tissues with alundum. In the case of Berkefeld V tissue filtrates, bacterial sterility was tested against B. prodigiosus in the usual manner (1).…”

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confidence: 99%

“…regular passage series of the Xyl71 strain of virus and had been inocuhted intratesticularly (1). 10 to 15 per cent emulsions by weight were made with Locke's solution by grinding the tissues with alundum.…”

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Studies on the Etiology of Rabbit Pox

Rosahn

Pearce

1936

Journal of Experimental Medicine

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In the first paper of this series (1) the experimental transmission of rabbit pox from spontaneous cases of the disease and the pathogenic properties of the causative agent, a filterable virus, were reported. The clinical characteristics of the experimentally induced disease which were described in the second paper (2) were found to be indistinguishable from cases of spontaneous pox.The work on experimental pox included experiments on the immunological aspects of the reaction to the infection, in which connection comparisons with other filterable viruses were made. The experiments which dealt with the inoculation of recovered (immune) rabbits are reported in this paper. In this study the viruses of pox, vaccinia, virus III disease, and infectious myxoma of rabbits were used in various combinations. The results on the exposure of recovered rabbits to clinical cases of pox are also presented, the original infections in these cases being pox, vaccinia, or virus III disease. And finally, the results on the cutaneous reaction of a calf to inoculation with pox, dermovaccine, culture (dermo) vaccine, and neurovaccine are also included. The following paper contains the results of serum-virus neutralization experiments (3). Materials and MethodsRabbit Pox Virus.--Tissue emulsions were prepared from the testicles of rabbits with an acute pox orchitis. The animals for the most part belonged to the 353

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The Pathogenesis of the Acute Exanthems

Mims

1996

Rev. Med. Virol.

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Epidemiological aspects of spontaneously acquired vaccinia in the rabbit

Cited by 4 publications

References 4 publications

Studies on the Etiology of Rabbit Pox

Studies on the Etiology of Rabbit Pox

Studies on the Etiology of Rabbit Pox

The Pathogenesis of the Acute Exanthems

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