Epidemiological burden estimates for pathologies with a nonconstant risk

Mancusi, Rossella Letizia; Andreoni, Massimo; d’Angela, Daniela; Sarrecchia, C.; Spandonaro, Federico

doi:10.1097/md.0000000000005143

Cited by 7 publications

(6 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, other studies estimate higher rates [17,18]. Mancusi et al [17] in a meta-analysis hypothesize national prevalence rates of HCV infection of 2.6%. Similarly, Andriulli et al [18] has reported a prevalence of HCV-Ab of 2.3%.…”

Section: Discussionmentioning

confidence: 96%

“…Large studies indicate that the prevalence rates of HCV seropositivity in Italy is 1.1% and for HBV it is less than 1% [9,16]. However, other studies estimate higher rates [17,18]. Mancusi et al [17] in a meta-analysis hypothesize national prevalence rates of HCV infection of 2.6%.…”

Section: Discussionmentioning

confidence: 99%

“…Similarly, Andriulli et al [18] has reported a prevalence of HCV-Ab of 2.3%. Many studies have shown an increasing North-South gradient [17,19,20].…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Epidemiology of HCV and HBV in a High Endemic Area of Southern Italy: Opportunities from the COVID-19 Pandemic—Standardized National Screening or One Tailored to Local Epidemiology?

Nevola

Messina

Marrone

et al. 2022

Biology

View full text Add to dashboard Cite

The COVID-19 pandemic led to the hospitalization of an unselected population with the possibility to evaluate the epidemiology of viral hepatitis. Thus, a retrospective multicenter study was conducted in an area of Southern Italy with the aim of assessing the prevalence of HCV and HBV markers and the ability of current screening program to capture cases. We evaluated 2126 hospitalized patients in seven COVID Centers of Naples and Caserta area in which 70% of the Campania population lives. HBsAg and HCV-Ab prevalence was 1.6% and 5.1%, respectively, with no differences between gender. Decade distribution for birth year shows a bimodal trend of HCV prevalence, with a peak (11.6%) in the decade 1930–1939 and a second peak (5.6%) for those born in 1960–1969. An analysis of the screening period imposed by the Italian government for those born between 1969 and 1989 shows that only 17% of cases of HCV infection could be captured. A small alignment of the screening period, i.e., those born from 1960 to 1984, would capture 40% of cases. The data confirm the high endemicity of our geographical area for hepatitis virus infections and underline the need for a tailored screening program according to the regional epidemiology.

show abstract

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Epidemiology of HCV and HBV in a High Endemic Area of Southern Italy: Opportunities from the COVID-19 Pandemic—Standardized National Screening or One Tailored to Local Epidemiology?

Nevola

Messina

Marrone

et al. 2022

Biology

View full text Add to dashboard Cite

show abstract

“…Major characteristics of the included articles, according to the method types (SR only, summary statistics and MA), are shown in Table 1. Of these 36 articles, 5 (14%) were SR only [29][30][31][32][33], (42%) used summary statistics [14,16,[34][35][36][37][38][39][40][41][42][43][44][45][46], and 16 (44%) used MA methods [47][48][49][50][51][52][53][54][55][56][57][58][59][60][61][62].…”

Section: Characteristics Of Included Articlesmentioning

confidence: 99%

Frequent inappropriate use of unweighted summary statistics in systematic reviews of pathogen genotypes or genogroups

Tran

Y²,

Nghia³

et al. 2020

Journal of Clinical Epidemiology

View full text Add to dashboard Cite

This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

show abstract

“…In Italy, in recent decades, there has been a change in the epidemiology of viral hepatitis thanks to improved hygienic and socio-economic conditions. However, the HCV epidemics in Italy is still the highest [16] among Western European countries, with GT 1 (a and b subtypes) the most prevalent (with a different prevalence 65–45% according to the human immunodeficiency virus [HIV] coinfection status: HIV-/HIV+), followed by GT 3 (about 19–36%, HIV-/HIV+), GT 2 and GT 4 (about 8–3% and 9–11%, HIV-/HIV+ respectively) and finally GT 5 (about <1%) [17,18,19,20].…”

Section: Introductionmentioning

confidence: 99%

NS5A Gene Analysis by Next Generation Sequencing in HCV Nosocomial Transmission Clusters of HCV Genotype 1b Infected Patients

Bellocchi

Aragri

Carioti

et al. 2019

Cells

View full text Add to dashboard Cite

Background: The aim of the study was to investigate the intra-host variability through next-generation-sequencing (NGS) of the NS5A-gene in nosocomial transmission-clusters observed in two Italian hospitals among hepatitis C virus (HCV)-genotype-1b infected patients. Methods: HCV-sequencing was performed by Sanger-sequencing (NS3 + NS5A + NS5B) and by NGS (NS5A, MiSeq-Illumina) in 15 HCV-1b infected patients [five acute with onco-hematologic-disease and 10 (4/6 acute/chronic) with β-thalassemia]. Resistance-associated-substitutions (RAS) were analysed by Geno2pheno-algorithm. Nucleotide-sequence-variability (NSV, at 1%, 2%, 5%, 10% and 15% NGS-cutoffs) and Shannon entropy were estimated. Phylogenetic analysis was performed by Mega6-software and Bayesian-analysis. Results: Phylogenetic analysis showed five transmission-clusters: one involving four HCV-acute onco-hematologic-patients; one involving three HCV-chronic β-thalassemia-patients and three involving both HCV-acute and chronic β-thalassemia-patients. The NS5A-RAS Y93H was found in seven patients, distributed differently among chronic/acute patients involved in the same transmission-clusters, independently from the host-genetic IL-28-polymorphism. The intra-host NSV was higher in chronic-patients versus acute-patients, at all cutoffs analyzed (p < 0.05). Even though Shannon-entropy was higher in chronic-patients, significantly higher values were observed only in chronic β-thalassemia-patients versus acute β-thalassemia-patients (p = 0.01). Conclusions: In nosocomial HCV transmission-clusters, the intra-host HCV quasispecies divergence in patients with acute-infection was very low in comparison to that in chronic-infection. The NS5A-RAS Y93H was often transmitted and distributed differently within the same transmission-clusters, independently from the IL-28-polymorphism.

show abstract

Epidemiological burden estimates for pathologies with a nonconstant risk

Abstract: Supplemental Digital Content is available in the text

Cited by 7 publications

References 28 publications

Epidemiology of HCV and HBV in a High Endemic Area of Southern Italy: Opportunities from the COVID-19 Pandemic—Standardized National Screening or One Tailored to Local Epidemiology?

Epidemiology of HCV and HBV in a High Endemic Area of Southern Italy: Opportunities from the COVID-19 Pandemic—Standardized National Screening or One Tailored to Local Epidemiology?

Frequent inappropriate use of unweighted summary statistics in systematic reviews of pathogen genotypes or genogroups

NS5A Gene Analysis by Next Generation Sequencing in HCV Nosocomial Transmission Clusters of HCV Genotype 1b Infected Patients

Contact Info

Product

Resources

About