Epidemiological Case-Control Study on the Etiology of
Bladder Cancer in Turkey

Akdaş, Atıf; Kirkali, Ziya; Bilir, Nazmi

doi:10.1159/000463993

Cited by 27 publications

(13 citation statements)

References 9 publications

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“…It was found in our study that Turkish coffee consumption was not associated with bladder cancer (p = 0.89). Although it was reported that coffee consumption created a very small risk in the etiology of bladder cancer in a metaanalysis of 14 studies [5,10], it was also suggested in those studies that smoking might also be a factor [11]. In our study, black tea consumption was not associated with bladder cancer (p = 0.37).…”

Section: Discussioncontrasting

confidence: 67%

“…Because the number of patients who consume alcohol was small within the study group, we believed that the interpretation of this result required caution. In many studies no increase in the risk of bladder cancer specific to the total amount consumed and the type of alcohol was found [7,8,10,13]. But it was found that the risk increased with alcohol intake in a meta-analysis [14] and a prospective study [15].…”

Section: Discussionmentioning

confidence: 99%

“…For the last four decades, it has been reported in many epidemiological studies [10,18,19] and reviews [9,16,17] that smoking increases the risk of bladder cancer. Zeegers and colleagues [9] reported in their study that there was a relation between the period and the amount of smoking.…”

Section: Discussionmentioning

confidence: 99%

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The association between personal habits and bladder cancer in Turkey

et al. 2008

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Section: Discussioncontrasting

confidence: 67%

Section: Discussionmentioning

confidence: 99%

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The association between personal habits and bladder cancer in Turkey

et al. 2008

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“…11). On the other hand, several older studies have not found statistically significant increases in risk associated with familial history of cancer (7,9,(29)(30)(31)(32)(33).…”

Section: Discussionmentioning

confidence: 93%

Risk of Bladder Cancer Associated with Family History of Cancer: Do Low-Penetrance Polymorphisms Account for the Increase in Risk?

Murta-Nascimento

Silverman

Kogevinas

et al. 2007

Cancer Epidemiology, Biomarkers &Amp; Prevention

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The relationship between family history of cancer in firstdegree relatives and risk of bladder cancer was examined in the Spanish Bladder Cancer Study. Information on family history of cancer was obtained for 1,158 newly diagnosed bladder cancer cases and 1,244 controls included in 18 hospitals between 1998 and 2001. A total of 464 (40.1%) cases and 436 (35.1%) controls reported a family history of cancer in z1 relative [odds ratio (OR), 1.32; 95% confidence interval (95% CI), 1.11-1.59]; the OR was 1.23 (95% CI, 1.01-1.50) among those with only one relative affected and 1.67 (95% CI, 1.23-2.29) among those with z2 affected relatives (P trend = 0.0004). A greater risk of bladder cancer was observed among those diagnosed at age V45 years (OR, 2.67; 95% CI, 1.10-6.50) compared with those diagnosed over age 45 years (OR, 1.27; 95% CI, 1.06-1.52). The OR of bladder cancer among subjects reporting a family history of cancer of the bladder was 2.34 (95% CI, 0.95-5.77). Statistically significant associations emerged between bladder cancer risk and family history of cancer of the esophagus, lung, prostate, and brain. The OR of bladder cancer for those reporting family history of bladder cancer was 4.76 (95% CI, 1.25-18.09) among NAT2-slow acetylators and 1.17 (95% CI, 0.17-7.86) among NAT2-rapid/ intermediate acetylators (P interaction = 0.609). Among individuals with GSTM1 null and present genotypes, the corresponding ORs were 2.91 (95% CI, 0.44-19.09) and 4.21 (95% CI, 1.26-14.14), respectively (P interaction = 0.712). Limitations of our study are small sample size in subgroup analyses, reliability of family history data, and possible residual confounding by shared environmental exposures. Overall, our findings support the hypothesis that genetic factors play a role in bladder cancer etiology. Whether these correspond to low-penetrance cancer-predisposing polymorphisms acting together and/or interacting with environmental factors warrants further research. (Cancer Epidemiol Biomarkers Prev 2007;16(8):1595 -600)

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“…Upon closer examination, sixteen articles did not provide sufficient information to estimate a summary odds ratio and its 95% confidence intervals [17][18][19][20][21][22], or a summary odds ratio adjusted for at least age, sex and smoking [23][24][25][26][27][28][29][30][31][32]. The remaining 19 articles [33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50][51] were chosen for detailed review.…”

Section: Resultsmentioning

confidence: 99%