Epidemiological characteristics and clinical manifestations of acute non-A-E hepatitis

Delic, Dragan; Mitrović, Nenad; Spurnić, Aleksandra Radovanović; Svirtlih, Neda; Babić, Jasmina Simonović

doi:10.2298/vsp1011903d

Cited by 6 publications

(5 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cases with a clinical picture and biochemistry parameters suggestive of viral hepatitis with negative viral markers and no prior history of exposure to toxins and drugs are classifi ed as seronegative hepatitis. [18,19] Tests for metabolic disease Blood and urine samples are analyzed in the specialized laboratories of the National Medical Genetics Center (CNGM) to identify congenital errors of metabolism (alpha 1 antitrypsin defi ciency, galactosemia, tyrosinemia, Wilson disease, neonatal hemochromatosis, fatty acid beta-oxidation disorders and other enzyme defi ciencies). According to causal inference guidelines, toxic causes (carbon tetrachloride, halothane, and potentially hepatotoxic herbs and drugs) are excluded in the absence of immediate exposure or exposure up to six months prior to ALF onset.…”

Section: Data Collectionmentioning

confidence: 99%

Acute Liver Failure in Cuban Children

Silverio¹,

Smithen-Romany²,

Hondal³

et al. 2015

MEDICC Review

View full text Add to dashboard Cite

INTRODUCTION Acute liver failure is rare in pediatric patients and is one of the most challenging medical emergencies due to its prognostic and therapeutic implications. The best scientifi c evidence worldwide comes from multicenter studies in developed countries. In Cuba, there are no prior studies of this disorder in children.OBJECTIVES Describe the main clinical features of Cuban children treated at a national referral center for acute liver failure, as defi ned by recognized diagnostic criteria for pediatric patients.METHODS A case series study was conducted comprising patients diagnosed with acute liver failure treated from 2005 to 2011 in the hepatology and liver transplant service at Havana's William Soler University Children's Hospital. Variables were age group, etiology of acute liver failure, grade of hepatic encephalopathy, blood chemistry variables, and clinical outcome (whether or not spontaneous recovery of liver function occurred). Associations between variables were assessed using contingency tables, and case fatality was calculated, as well as relative risk with its 95% confi dence interval. The Mann-Whitney U test was used to compare means of laboratory test results. RESULTSMedian age of the 31 patients studied (14 boys and 17 girls) was 24 months (range 1-180). Time between symptom onset and diagnosis of acute liver failure was 25.1 days (SD 16.8). Infection was the most common etiology, present in 61.3% of cases (19/31); nonhepatotropic viruses, especially cytomegalovirus, predominated in infants. Spontaneous recovery occurred in 15 patients (48.4%), 3 (9.7%) received transplants, and 13 died, for a case fatality of 41.9%. Outcome was not associated with etiology (p = 0.106), but was statistically associated with degree of hepatic encephalopathy (p <0.01): 77.8% of patients (7/9) with grades III-IV encephalopathy died, for a relative risk of 4.0 (95% CI 1.15-13.8), versus 11.1% (1/9) with grade II or less encephalopathy. Cholesterol levels were signifi cantly lower in patients who failed to recover spontaneously (p <0.01).CONCLUSIONS Patients' clinical characteristics in this case series were similar to those described in developed countries.The fact that nonhepatotropic viruses (basically, cytomegalovirus in infants) are the main cause of acute liver failure in Cuban children calls for further epidemiologic study and identifi cation of local underlying determinants of this phenomenon.

show abstract

Section: Data Collectionmentioning

confidence: 99%

Acute Liver Failure in Cuban Children

Silverio¹,

Smithen-Romany²,

Hondal³

et al. 2015

MEDICC Review

View full text Add to dashboard Cite

show abstract

“…Hepatitis B has an incubation period ranging The 2nd International Meeting of Public Health 2016 from 6 weeks up to 6 months to clinical symptoms [7]. Hepatitis C has an incubation period of between 15-160 days, an average of about 50 days [8,16] (Safioleas & Manti 2007).…”

Section: Introductionmentioning

confidence: 99%

Risk Factor for Blood-borne Disease (Study in Blood Donors at Semarang District)

Rahayu¹,

Ginandjar²,

Saraswati³

2018

KLS

View full text Add to dashboard Cite

Blood-borne disease is one of communicable disease through blood contamination.The aims of this study to determine risk factors for diseases transmitted from blood donors in Semarang District. The design study was a cross sectional with analytic approach. The subjects were blood donors (400 people) using an accidental sampling method. Statistical analyzed with fisher exact test and prevalence ratio with 95% significance level. Results showed the prevalence of hepatitis B and HIV was 1.5% (6 people) and 0.5% (2 people). Hepatitis C infection in this study was not found. From the statistical test showed that history of sexual behavior as a risk factor incidence of infectious disease through blood POR = 30.992; 95% CI (6.908 -139.041) with p = 0.001. Knowledge, types of injection drug use, sharing needles, blood transfusions, organ transplants, surgery, dialysis, dental examination, tattooing and piercing, and contact with the patient were not risk factors for the incidence of infectious diseases through blood in Semarang District. Indonesia Red Cross in Semarang District should conduct dissemination to the blood donors on the sidelines of the implementation of activities related blood donor infectious diseases transmitted by blood including agent, transmission, natural history, prevention and treatment.

show abstract

“…Epidemiologic information related to non-A-E hepatitis is scarce. In a study by Delic et al 2010, analysing 408 patients with acute hepatitis, history of blood transfusion, drug use or other parenteral exposure were not associated with the onset of illness [ 7 ], suggesting that if the viral nature of non-A-E hepatitis is proven, it should spread primarily by non-parenteral means. Moreover, some patients diagnosed with acute non-A-E hepatitis show biochemical features at admission similar to those associated with other viral hepatitis.…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, some patients diagnosed with acute non-A-E hepatitis show biochemical features at admission similar to those associated with other viral hepatitis. Apparently, acute non-A-E hepatitis is distributed worldwide, and progression to chronicity was observed in approximately 9% of patients [ 7 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

Identification of sapovirus GV.2, astrovirus VA3 and novel anelloviruses in serum from patients with acute hepatitis of unknown aetiology

et al. 2017

View full text Add to dashboard Cite

Hepatitis is a general term meaning inflammation of the liver, which can be caused by a variety of viruses. However, a substantial number of cases remain with unknown aetiology. We analysed the serum of patients with clinical signs of hepatitis using a metagenomics approach to characterize their viral species composition. Four pools of patients with hepatitis without identified aetiological agents were evaluated. Additionally, one pool of patients with hepatitis E (HEV) and pools of healthy volunteers were included as controls. A high diversity of anelloviruses, including novel sequences, was found in pools from patients with hepatitis of unknown aetiology. Moreover, viruses recently associated with gastroenteritis as sapovirus GV.2 and astrovirus VA3 were also detected only in those pools. Besides, most of the HEV genome was recovered from the HEV pool. Finally, GB virus C and human endogenous retrovirus were found in the HEV and healthy pools. Our study provides an overview of the virome in serum from hepatitis patients suggesting a potential role of these viruses not previously described in cases of hepatitis. However, further epidemiologic studies are necessary to confirm their contribution to the development of hepatitis.

show abstract

Epidemiological characteristics and clinical manifestations of acute non-A-E hepatitis

Abstract: Based on the results obtained in this study, it is probable that there are some so far undetected primary hepatotropic viruses in our environment.

Cited by 6 publications

References 20 publications

Acute Liver Failure in Cuban Children

Acute Liver Failure in Cuban Children

Risk Factor for Blood-borne Disease (Study in Blood Donors at Semarang District)

Identification of sapovirus GV.2, astrovirus VA3 and novel anelloviruses in serum from patients with acute hepatitis of unknown aetiology

Contact Info

Product

Resources

About