Epidemiological Characteristics of OXA-232-Producing Carbapenem-Resistant Klebsiella pneumoniae Strains Isolated during Nosocomial Clonal Spread Associated with Environmental Colonization

Abstract

OXA-232 is a variant of OXA-48 carbapenemase, which has been increasingly reported in nosocomial outbreaks in ICUs. However, the OXA-232-CRKP transmission relationship between the environment and patients in ICUs was still not clear.

Genome sequencing unveils bla KPC-2 -harboring plasmids as drivers of enhanced resistance and virulence in nosocomial Klebsiella pneumoniae

“…Furthermore, we observed the evolution of carbapenem-resistance plasmids during the clonal spread of CRKP. Notably, our previously reported study revealed a correlation between long-term colonization and the risk of further infection ( 30 ). Considering these findings, we strongly recommend the implementation of regular surveillance measures for CRKP in both patient and environmental settings.…”

“…From 1 August to 31 December 2019, a CRKP screening program was performed in the ward environments and patients in the ICU in Sir Run Run Shaw Hospital (Zhejiang Province, China), as reported before ( 30 ). Briefly, the patient’s anatomic sites for sampling included rectal swab, nasointestinal tube, nasogastric tube, oral swab, tracheotomy tube, and endotracheal intubation.…”

Epidemiology and Genetic Characteristics of Carbapenem-Resistant Escherichia coli in Chinese Intensive Care Unit Analyzed by Whole-Genome Sequencing: a Prospective Observational Study

“…Continuous monitoring of the decreasing susceptibility of multidrug-resistant bacteria to disinfectants helps to effectively control and prevent the spread of superresistant bacteria. Our previous study revealed that the detected CRKP carried disinfectant resistance genes and virulence clusters and recommended the appropriate use of disinfectants to prevent the development of resistance ( 30 ).…”

Global Phylogeography and Genomic Epidemiology of Carbapenem-Resistant blaOXA-232–Carrying Klebsiella pneumoniae Sequence Type 15 Lineage

“…One of the most prevalent carbapenemase genes, bla OXA-48 (oxacillin-hydrolyzing β-lactamase), is found predominantly on large and transferable plasmids in bacteria of order Enterobacterales. Prevalence of K. pneumoniae strains carrying a bla OXA-48 –like gene in China increased during 2018–2022 ( 3 – 6 ). Nosocomial outbreaks, including among pediatric patients, have called attention to the importance of better understanding the transmission potential of CRKP isolates carrying the bla OXA-48 –like gene ( 4 – 6 ).…”

“…Prevalence of K. pneumoniae strains carrying a bla OXA-48 –like gene in China increased during 2018–2022 ( 3 – 6 ). Nosocomial outbreaks, including among pediatric patients, have called attention to the importance of better understanding the transmission potential of CRKP isolates carrying the bla OXA-48 –like gene ( 4 – 6 ).…”