Epidemiological characteristics of postoperative sepsis

Chen, Po-Yi; Luo, Ci-Wen; Chen, Mu-Hsing; Yang, Ming-Ling; Kuan, Yu‐Hsiang

doi:10.1515/med-2019-0110

Cited by 12 publications

(9 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Even though our analysis showed that the proportion of diabetes and hypertension in comorbidities was higher and the ratio of chronic heart failure reached 28.71%, none showed an increase in the risk of death. This result differs than what was reported by Sinapidis D et al [ 15 ] and Chen PY et al [ 16 ], which may be associated with the demographic characteristics of this study population. As the subjects of this study were urosepsis patients, the proportion of patients requiring mechanical ventilation was not high.…”

Section: Discussioncontrasting

confidence: 99%

Clinical characteristics and prognosis in patients with urosepsis from intensive care unit in Shanghai, China: a retrospective bi-centre study

et al. 2021

View full text Add to dashboard Cite

Background The purpose of this study was to retrospectively analyze clinical characteristics and prognostic risk factors of urosepsis patients admitted to two intensive care units in Shanghai, China. Methods Clinical data from patients diagnosed with urosepsis were retrospectively retrieved and analyzed from ICU in two regional medical centers from January 2015 to December 2019. Results Two hundred two patients were included in the subsequent analysis eventually, with an average age of 72.02 ± 9.66 years, 79.21% of the patients were female and the mortality rate of 15.84%.The proportion of patients with chronic underlying diseases such as diabetes and hypertension was relatively high (56.44, 49.50%, respectively), and the incidence of shock was also high (41.58%) correspondingly. The most common pathogen isolated was Escherichia coli (79.20%), of which the extended-spectrumβ-lactamases (ESBLs)(+) accounted for 42.57%. In multivariate analysis, the strongest predictors for death were mechanical ventilation (OR 7.260, 95% CI 2.200–23.963; P = 0.001),chronic kidney disease (CKD) (OR 5.140, 95% CI 1.596–16.550; P = 0.006), APACHE II score (OR 1.321, 95% CI 1.184–1.473; P < 0.001) and lactate (OR 1.258, 95% CI 1.037–1.527; P = 0.020). Both APACHE II score and lactate had the ideal predictive value, with the area under the ROC curve (AUC) of 0.858 and 0.805 respectively. Conclusion The patients with urosepsis were characterized by a higher proportion of female, older age, more percentage of comorbidities in this region, and patients with ESBLs (+) Escherichia coli infection were more prone to shock. Mechanical ventilation, comorbidity with CKD, APACHE II score and lactate were independent risk factors for death in urosepsis patient, but lactate level and APACHE II score had better predictive value for prognosis.

show abstract

Section: Discussioncontrasting

confidence: 99%

Clinical characteristics and prognosis in patients with urosepsis from intensive care unit in Shanghai, China: a retrospective bi-centre study

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Patients’ preoperative status and lifestyle choices contribute to modifying the relative risk. In addition, the type of surgery also has an impact, as gastric, biliary and colorectal surgeries were associated with relatively higher rates of postoperative sepsis, when at the same time esophageal surgery had the lowest risk of postoperative sepsis[ 44 - 46 ] (Figure 2 ). Although the incidence is rising, especially in elderly patients, mortality rates are decreasing[ 47 ].…”

Section: Bacterial Translocation Abdominal Surgery and Postoperative Sepsismentioning

confidence: 99%

Bacterial translocation in patients undergoing major gastrointestinal surgery and its role in postoperative sepsis

Doudakmanis¹,

Bouliaris²,

Kolla³

et al. 2021

WJGP

View full text Add to dashboard Cite

Bacteria of the human intestinal microflora have a dual role. They promote digestion and are part of a defense mechanism against pathogens. These bacteria could become potential pathogens under certain circumstances. The term “bacterial translocation” describes the passage of bacteria of the gastrointestinal tract through the intestinal mucosa barrier to mesenteric lymph nodes and other organs. In some cases, the passage of bacteria and endotoxins could result in blood stream infections and in multiple organ failure. Open elective abdominal surgery more frequently results in malfunction of the intestinal barrier and subsequent bacterial translocation and blood stream infections than laparoscopic surgery. Postoperative sepsis is a common finding in patients who have undergone non-elective abdominal surgeries, including trauma patients treated with laparotomy. Postoperative sepsis is an emerging issue, as it changes the treatment plan in surgical patients and prolongs hospital stay. The association between bacterial translocation and postoperative sepsis could provide novel treatment options.

show abstract

“…Similar to other studies (15,(31)(32)(33), male rats were selected for sepsis model because the tolerance effects on sepsis differ between sexes. Male patients are at high risk for developing sepsis (34)(35)(36), and women are more resistant to sepsis (37). A single-sex study may increase model reproducibility by reducing physiological heterogeneity due to sex differences (38,39).…”

Section: Discussionmentioning

confidence: 99%

A Modified Surgical Sepsis Model Satisfying Sepsis-3 and Having High Consistency of Mortality

Wang

Liao

Chen

et al. 2023

Shock

View full text Add to dashboard Cite

Background: Cecal ligation and perforation (CLP) is currently considered the criterion standard model of sepsis; however, there are some deficiencies, such as low clinical relevance, inconsistency in severity grading, and an unknown proportion of CLP animals meeting the requirements of sepsis-3. Methods: Adult rats were randomly divided into the following three groups: modified CLP (M-CLP) group, CLP group, and sham group. The vital organ function of rats was evaluated 24 hours postoperatively by blood pressure, behavioral testing, histopathology, and blood test. Cytokine levels were determined by enzyme-linked immunosorbent assay, and T-cell suppression was assessed by flow cytometry. The stability of the model was evaluated by comparing the survival rates of repeated experiments in all groups from day 1 to day 14. Results: More rats in the M-CLP group met Sepsis-3 criteria than those in the CLP group 24 hours postoperatively (53.1% vs. 21.9%, P = 0.01). Rats in the M-CLP group developed more serious hepatic, pulmonary, and renal dysfunction. Similar to human sepsis, rats in the M-CLP group demonstrated more serious immunosuppression and systemic inflammation compared with the CLP group. In addition, disease development and severity, which was indicated by the stable survival rates of model animals, were more stable in the M-CLP group. Conclusions: More rats could meet Sepsis-3 criteria with this novel surgical procedure, which may reduce the number of animals needed in preclinical sepsis experiments. This stable M-CLP model may contribute to the development of new therapies.

show abstract

Epidemiological characteristics of postoperative sepsis

Abstract: AbstractBackgroundPostoperative sepsis is a major type of sepsis. Sociodemographic characteristics, incidence trends, surgical procedures, comorbidities, and organ system dysfunctions related to the disease burden of postoperative sepsis episodes are unclear.MethodsWe a… Show more

Cited by 12 publications

References 30 publications

Clinical characteristics and prognosis in patients with urosepsis from intensive care unit in Shanghai, China: a retrospective bi-centre study

Clinical characteristics and prognosis in patients with urosepsis from intensive care unit in Shanghai, China: a retrospective bi-centre study

Bacterial translocation in patients undergoing major gastrointestinal surgery and its role in postoperative sepsis

A Modified Surgical Sepsis Model Satisfying Sepsis-3 and Having High Consistency of Mortality

Contact Info

Product

Resources

About