Epidemiological Characterization of Dermatomycosis in Ethiopia

Araya, Shambel; Abuye, Million; Negesso, Abebe Edao

doi:10.2147/ccid.s292286

Cited by 13 publications

(14 citation statements)

References 40 publications

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“…Local socio-economic conditions, cultural practices, population migration, lifestyle changes, injuries, shoes, pets (cats, dogs, hamsters), sports (swimming, running, wrestling) are some of the many risk factors for dermatomycosis development. The fact that the prevalence of dermatomycosis varies depending on age and sex has been established by many scientists in their studies and has been proven as a result of our studies [14], [15], [16], [17], [18]. We have found that dermatomycosis has a higher prevalence among men than among women.…”

Section: Discussionsupporting

confidence: 61%

Assessment of the Epidemiological Situation on the Dermatomycosis Incidence during Covid-19 Pandemic

Amreyeva

Shaizadina

Zhankalova

et al. 2022

Open Access Maced J Med Sci

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Абстрактный Актуальность изучения грибковых заболеваний кожи обусловлена их широкой распространенностью. Дерматомикоз поражает более 40% населения мира, в то время как онихомикоз (дерматофития ногтей), представляющая собой глобальную проблему здравоохранения, составляет около 18-40%. Цель: Оценка эпидемиологической ситуации по заболеваемости дерматомикозами в период пандемии коронавирусной инфекции в Карагандинской области. Материалы и методы исследования: В исследовании использовались статистические данные за период 2009-2020 гг. Результаты: Анализ многолетней динамики заболеваемости дерматомикозами за период 2009-2020 гг. выявил неравномерность течения эпидемического процесса в Карагандинской области. Общее обилие грибов, вызывающих дерматомикозы, преобладает среди мужского населения. Анализ данных по возрасту показал, что чаще всего заболеваемость регистрировалась среди лиц до 35 лет. Дерматомикозы чаще выявляли у подростков и детей до 14 лет по сравнению со взрослыми. Анализ факторов риска развития дерматомикозов в популяции показал, что заболеваемость, связанная с грибковой инфекцией, в 59,2% случаев была обусловлена контактом с животными. Заключение . Распространенность тяжелых форм дерматомикозов среди городского населения была в 1,4 раза выше, чем среди жителей сельской местности. Мужчины болеют дерматомикозами в 1,64 раза чаще, чем женщины. Отмечены факторы, влияющие на распространение инфекционных дерматозов. Это климатические особенности центрального района республики, способствующие накоплению возбудителя в очагах инфекции, а также несвоевременное обращение за медицинской помощью, самолечение, низкая информированность о данной патологии, в частности профилактические мероприятия. . Ключевые слова: дерматомикозы, заболеваемость, эпидемиология, распространенность, возрастные группы, население, Карагандинская область.

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Section: Discussionsupporting

confidence: 61%

Assessment of the Epidemiological Situation on the Dermatomycosis Incidence during Covid-19 Pandemic

Amreyeva

Shaizadina

Zhankalova

et al. 2022

Open Access Maced J Med Sci

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“…(32%) Epidermophyton spp. (20.2%), and Aspergillus fumigatus (8.3%) were the most common dermatophytes [ 20 ]. Thus, a wide variation in the organisms of dermatophytes exists between countries and with regions of any country.…”

Section: Discussionmentioning

confidence: 99%

“…The JHAH hospital in Dhahran is a 350-bed general hospital and provides medical care for about 160,000 individuals eligible for medical care. The study was approved by the Institutional Review Board (IRB) of Imam Abdulrahman Bin Faisal University (IRB-PGS-2018-03-175) and the IRB of JHAH (IRB # [18][19][20][21]. Fungal culture data from 2000 to 2019 period were obtained from the Laboratory Information System of the Mycology Laboratory at JHAH and from the electronic laboratory information system.…”

Section: Methodsmentioning

confidence: 99%

Epidemiology of Dermatophytes Isolated from Clinical Samples in a Hospital in Eastern Saudi Arabia: A 20-Year Survey

Alshehri

Alamri

Rabaan

et al. 2021

J Epidemiol Glob Health

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Background Dermatophytes are group of fungi that cause superficial infections via enzymes that degrade keratin in human skin. Several factors, including climate, gender, age, lifestyle, human migration, cultural habits, and socioeconomic status influence the prevalence of dermatophyte infections. We analyzed the prevalence of dermatophyte isolates in a hospital in Eastern Saudi Arabia from 2000 to 2019. Methods The data on fungal cultures were obtained from the Laboratory Information System of the Mycology Laboratories at Johns Hopkins Aramco Healthcare, and were used for the analysis. Fungal isolates were examined microscopically for the presence of specialized hyphal structures and conidia. The Vitek® MS microbial identification system (biomerieux) was used if the culture type was not identified microscopically. Results Among the 10,021 samples analyzed, 3040 (30.33%) were positive for fungi and only 398 (3.97%) were dermatophytes. Microsporum species was the most common dermatophyte accounting for 50.5% (n = 201) followed by trichophyton with 36.9% (n = 147). The most common positive samples were scrapping (251, 63%) and hair (68, 17%). Culture positivity relative to the age groups revealed a cluster of positive dermatophyte species in children < 10 years of age with 215 (54%) of all cases and among 10–19 years of age with 60 (15) of the cases (p < 0.001). Microsporum species were the prevalent dermatophytes in patients < 10 years of age, while Epidermophyton species were the most frequent dermatophyte species in age groups 10–19, 20–29, and 30–39 years. However, Trichophyton species were the most frequent dermatophyte species in individuals 70–79 years. The percentage of Microsporum and Trichophyton species decreased significantly over time (p < 0.001). In addition, there was a significant seasonal variation in relation to Trichophyton species. A comparison between the most frequent species showed that there was no difference in relation to gender, but there was a difference in relation to the specimen type and age group. Conclusion Dermatophytosis was common among children and adolescent with the most common samples were scrapping and hair. There was a significant reduction in Microsporum and Trichophyton species over time.

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“…Reports indicate health concerns due to public parks and school playgrounds as ideal environment for the growth of pathogenic fungal dermatophytes (Dehghan et al 2019 ; Taghipour et al 2021 ). Especially, prevalence of dermatophytic infections is more common in tropical countries due to high temperature, humidity and sweating (de Albuquerque Maranhão et al 2019 ; Araya et al 2021 ; Khodadadi et al 2021 ). Besides the evolutionary pressure from the antifungal drugs, it is now identified that environmental pressures including the climate change are affecting the fungal evolution to confer novel traits including virulence and antifungal resistance (Nnadi and Carter 2021 ).…”

Section: Discussionmentioning

confidence: 99%

In vitro antidermatophytic activity of bioactive compounds from selected medicinal plants

2021

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Fungal infections are among the most difficult diseases to manage in humans. Eukaryotic fungal pathogens share many similarities with their host cells, which impairs the development of antifungal compounds. Therefore, it is desirable to harness the pharmaceutical potential of medicinal plants for antifungal drug discovery. In this study, the antifungal activity of sixteen plant extracts was investigated against selected dermatophytic fungi. Of the sixteen plants, the cladode (leaf) of Asparagus racemosus, and seed extract of Cassia occidentalis showed antifungal activity against Microsporum gypseum, Microsporum nanum, Trichophyton mentagrophytes and Trichophyton terrestre. The plant antifungal compounds were located by direct bioassay against Cladosporium herbarum. IR and NMR spectrometry analyses of these compounds identified the presence of saponin (in A. racemosus) and hydroxy anthraquinone (in C. occidentalis) in these antifungal compounds. The antidermatophytic activity of plant anthraquinone and saponins with reports of little or no hemolytic activity, makes these compounds ideal for alternative antifungal therapy and warrants further in-depth investigation in vivo.

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Epidemiological Characterization of Dermatomycosis in Ethiopia

Cited by 13 publications

References 40 publications

Assessment of the Epidemiological Situation on the Dermatomycosis Incidence during Covid-19 Pandemic

Assessment of the Epidemiological Situation on the Dermatomycosis Incidence during Covid-19 Pandemic

Epidemiology of Dermatophytes Isolated from Clinical Samples in a Hospital in Eastern Saudi Arabia: A 20-Year Survey

In vitro antidermatophytic activity of bioactive compounds from selected medicinal plants

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