Epidemiological characterization of oral cancer. Literature review.

Fernández, Alejandra; Córdova, Pablo; Badenier, Osvaldo; Esguep, Alfredo

doi:10.17126/joralres.2015.027

Cited by 8 publications

(7 citation statements)

References 36 publications

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“…1 An incidence of 500,000 cases per year has been reported worldwide. 2 OSCC may originate from malignant transformation of normal oral mucosa (NOM), and from potentially malignant lesions with different degrees of oral epithelial dysplasia (OED).…”

Section: Introductionmentioning

confidence: 99%

Difference in EGFR expression and mean vascular density in normal oral mucosa, oral epithelial dysplasia and oral squamous cell carcinoma.

Fernández¹,

Fernández

Marshall

et al. 2017

J Oral Res

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To evaluate the expression of the epidermal growth factor receptor (EGFR) and mean vascular density (MVD) in normal oral mucosa (NOM), oral epithelial dysplasia (OED) and oral squamous cell carcinoma (OSCC). Material and methods: Descriptive case study. Nineteen histological samples diagnosed with NOM, 18 diagnosed with OED, and 19 with OSCC, were analyzed with immunohistochemistry against EGFR and CD31. EGFR expression was evaluated by extent and intensity of its expression in normal, dysplastic and neoplastic epithelium. MVD was determined through the detection of blood vessels by antibodies against CD31. Results: Extension of EGFR expression was highest in OSCC followed by OED and lowest in NOM, resulting in significant different between the degrees of extension (p<0.001). Intensity of EGFR was similar in NOM, OED and OSCC, without differences in its expression (p=0.533). Differences in MVD were found between NOM and OSCC groups (p<0.01), and between OED and OSCC groups (p<0.01), with no differences between NOM and OED groups (p=0.91). MVD was 21.17±4.98 in NOM, 23.40±5.77 in OED and 33.92±8.39 in OSCC. Conclusion: EGFR is expressed in normal, dysplastic or neoplastic oral epithelium. However, the extent of its expression is greater as malignancy increases. MVD varies according to the diagnosis.

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Section: Introductionmentioning

confidence: 99%

Difference in EGFR expression and mean vascular density in normal oral mucosa, oral epithelial dysplasia and oral squamous cell carcinoma.

Fernández¹,

Fernández

Marshall

et al. 2017

J Oral Res

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“…Similar findings are described in most of the literature 8,9 . Over the past few years, an increase in the number of cases of the disease has been observed among younger patients and in women with no history of association with the most often associated risk factors 10,11 . It is speculated that in these cases individual genetic susceptibility influences the emergence of oral SCC, and the mutations related to DNA repair genes have been given great prominence 12 .…”

Section: Lip and Oral Cavity Tumorsmentioning

confidence: 99%

Epidemiological profile of oral squamous cell carcinoma in a Northeastern Brazilian state

França¹,

Silva²,

Silva³

et al. 2018

Arch. Head Neck Surg.

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Introduction: Oral squamous cell carcinoma (OSCC) is considered the 6 th most frequent worldwide type of cancer. Epidemiological surveys of cancer are important to understand how its distribution occurs in population, to create public policy of prevention and improvement of reference centers for treatment of this disease. Objective: To analyze the OSCC prevalence in Alagoas and draw the patients' clinical profile providing guiding data to health professionals according to profile of the lesion. Materials and Methods: A retrospective analysis of 341 medical charts of patients diagnosed with OSCC was performed at reference hospital for cancer treatment in Alagoas. Results: Out of 341 patients analyzed, 217 (63.6%) were men and 124 (36.4%) were women. The mean age for men was 59.86 years and 63.16 years for women. There was a predominance of individuals who did not complete the elementary school (62.8%). The tongue was the most affected by OSCC. The majority of lesion was in clinical stage III. So, the first therapeutic scheme of choice was the association of radiotherapy and chemotherapy. Conclusion: Low educational level and poor socioeconomic development rates show that individuals affected by OSCC are probably more vulnerable to etiological agents often related to its occurrence.

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“…La mayoría de investigadores concuerdan afirmando que estos tejidos -como, por ejemplo, la mucosa oral, e inclusive la gastrointestinal-, suelen ser objetivos primarios de la toxicidad relacionada con el tratamiento a causa de su tasa rápida de renovación celular. Por lo tanto, se encuentran variados estudios que evidencian múltiples efectos sintomáticos durante y posterior a los tratamientos oncológicos, que desencadenan en el paciente un estado significativo agudo de incomodidad e incapacidad, como lo son las mucositis bucales (mb) en sus diferentes estadios, trismo, disfagia y xerostomía, entre otras [3,[10][11][12][13][14][15][16][17][18][19].…”

Section: Introductionunclassified

“…Adicional a la cabeza y el cuello, las localizaciones anatómicas del cáncer distantes a la boca, se relacionan de una u otra forma con la presencia de lesiones estomatológicas, durante y posterior a la aplicación de qrt (incluyendo cirugía oncológica), puesto que sus efectos sistémicos son acumulativos e inherentes a los diferentes estados de inmunosupresión oncológica por las que suele cursar un paciente [13][14][15][16][17][18][19][20].…”

Section: Introductionunclassified

Condiciones estomatológicas en pacientes con cáncer durante y posterior al tratamiento antineoplásico: revisión narrativa de la literatura

2017

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Introducción: las consecuencias de los tratamientos antineoplásicos,traen consigo implicaciones bucales y empeoramiento de otras lesiones ya prestablecidas al diagnóstico oncológico, indistintamente del órgano afectado por eltumor. Complicaciones tales como las mucositis orales, candidiasis orales, trismo,xerostomía, caries, entre otras lesiones, suelen suceder con frecuencia, y puedenser transitorias en el curso de la aplicación de terapéuticas para el cáncer, como,por ejemplo, quimioterapia y radioterapia; otras prevalecen posterior a la finalizaciónde estas terapéuticas. Métodos: se realizó una revisión narrativa de la literaturaque mostró la unificación de criterios que involucran la descripción de los patronesclínicos de cada una de las complicaciones orales por el tratamiento oncológico,en relación con cánceres de diferentes localizaciones. Se efectuó una búsqueda bibliográfica en idioma inglés y español usando los siguientes descriptores: “lesiones,boca, cáncer, quimioterapia, radioterapia, complicaciones orales, antes y después,lesions, mouth cancer, chemotherapy, radiotherapy, oral complications, after y before, para las base de datos global Pubmed y Scielo. En esta se seleccionaron 100 artículos publicados en un período de 15 años. Resultados: la mayoría de autores consultados coinciden en afirmar que una amplia gama de tumores malignos tienden a mostrar afectación secundaria en lugares como la cavidad oral, en su mayoría porel tratamiento oncológico instaurado, sin distinción de tipo tumoral y localizacióndel mismo. Conclusiones: la cavidad bucal sigue siendo susceptible a la presenciade estos efectos, los cuales se identifican como eventos citotóxicos sistémicos entejidos de recambio rápido, como lo es la mucosa bucal.

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Epidemiological characterization of oral cancer. Literature review.

Cited by 8 publications

References 36 publications

Difference in EGFR expression and mean vascular density in normal oral mucosa, oral epithelial dysplasia and oral squamous cell carcinoma.

Difference in EGFR expression and mean vascular density in normal oral mucosa, oral epithelial dysplasia and oral squamous cell carcinoma.

Epidemiological profile of oral squamous cell carcinoma in a Northeastern Brazilian state

Condiciones estomatológicas en pacientes con cáncer durante y posterior al tratamiento antineoplásico: revisión narrativa de la literatura

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