Epidemiological, Clinical and Serological Characteristics of Children with Coronavirus Disease 2019 in Wuhan: A Single-centered, Retrospective Study

Luo, Dan; Xia, Zhi; Li, Heng; Tu, Danna; Wang, Ting; Zhang, Wei; Lü, Peng; Yi, Wenfu; Zhang, Sai; Shu, Junhua; Xu, Hui; Li, Yong; Shi, Bao; Huang, Chengjiao; Tang, Weiqin; Xiao, Shiyi; Shu, Xiaolan; Liu, Yan; Zhang, Yuan; Guo, Shan; Yu, Zhi Ling; Wang, Baoxiang; Gao, Yuan; Hu, Qinxue; Wang, Hanzhong; Song, Xiaohui; Hong, Ming; Zhou, Xiaoqin; Zheng, Zhenhua

doi:10.1007/s12250-020-00333-z

Cited by 4 publications

(4 citation statements)

References 21 publications

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“…The most common neurological manifestation in COVID-19 patients was headache. The mean prevalence was 8% in a systematic review [9] , followed by dizziness (7- 9.4%) and confusion [10] . Other manifestations were acute ischemic stroke, cerebral venous sinus thrombosis, cerebral haemorrhage, meningitis/encephalitis, and Guillain-Barre syndrome and acute necrotising haemorrhagic encephalopathy [11] .…”

Section: Discussionmentioning

confidence: 98%

Parkinsonism: An emerging post COVID sequelae

Rao

Hidayathullah

Hegde

et al. 2022

IDCases

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Parkinsonism has a complex and multifactorial aetiology and the role of post viral infection parkinsonism has been documented. The recent pandemic has made it clear that COVID-19 causes respiratory disease and affects multiple organs, which includes the central nervous system. Here we report three cases of post COVID parkinsonism occurring in older adults, age 60 years and above, and their response to levodopa-carbidopa.

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Section: Discussionmentioning

confidence: 98%

Parkinsonism: An emerging post COVID sequelae

Rao

Hidayathullah

Hegde

et al. 2022

IDCases

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“…The current investigation showed that SADS-CoV was only detected in Guangdong, but not in other areas; previous studies found it to exist in Fujian (Li et al 2018 ), so it is necessary to strengthen the monitoring of SADS-CoV to prevent it from spreading to other areas. Previous studies have shown that the coronavirus has extensive in vitro host tropism and can infect a variety of cell lines (Edwards et al 2020 ; Luo et al 2020 ; Yang et al 2020 , 2019 ). At the same time, mixed infections may lead to recombinations between viruses and changes in the virulence of the virus (Akimkin et al 2016 ; Ding et al 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Use of dual priming oligonucleotide system-based multiplex RT-PCR assay to detect five diarrhea viruses in pig herds in South China

Niu

Zhou

et al. 2021

AMB Expr

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In this study, a specific and simple method based on the dual priming oligonucleotide (DPO) system was developed to simultaneously detect transmissible gastroenteritis virus (TGEV), porcine epidemic diarrhea virus (PEDV), porcine rotavirus A (PRV-A), porcine delta coronavirus (PDCoV), and swine acute diarrhea syndrome coronavirus (SADS-CoV), associated with the major enteric RNA viruses in pigs. The DPO system-based multiplex RT-PCR method simplified the primer design and did not require optimization of the annealing temperature. Specificity analysis revealed that the method could specifically detect TGEV, PEDV, PRV-A, PDCoV, and SADS-CoV without any cross-amplification of other circulating swine viruses. The limit of detection of the method was as low as 103–104 copies/μL plasmid of each virus. The method also had good repeatability, and obvious results were seen in three repeat experiments with an interval of 45 days. This optimized multiplex RT-PCR method was used to evaluate 181 clinical swine samples that were collected from four provinces of China between September 2016 and August 2018. The results showed that the positive detection rates of PEDV, PDCoV, SADS-CoV, PRV-A, and TGEV were 30.94% (56/181), 17.67% (32/181), 11.6% (21/181), 9.39% (17/181), and 0.55% (1/181), respectively. Mixed infection of two or more viruses was also common. The DPO system-based multiplex RT-PCR could be a useful tool for detecting enteric virus infections. This method has the advantages of easy operation, low cost, high detection efficiency, and short running time for early diagnosis in clinical cases.

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“…Ever since the first case was reported in December (2019) from Wuhan (Hubei province, China) (Lu et al 2020a ), researchers across the globe are striving to develop a therapeutic intervention to control the pandemic. However, instead of the time consuming de novo drug discovery, repurposing of the approved drugs has been investigated more (Guo 2020 ). This has been facilitated by elucidation of the viral genome sequence and enzyme structures, which are the basis for drug discovery research (Baker 2020 ; Cunningham et al 2020 ).…”

Section: Introductionmentioning

confidence: 99%

“…The SARS-CoV-2 has a positive sense single stranded RNA genome of 29.9 kb (Lu et al 2020b ), comprising of 6–11 open reading frames (ORFs) (Guo 2020 ). The first ORF encodes 16 nonstructural proteins (NSPs) including two cysteine proteases, viz.…”

Section: Introductionmentioning

confidence: 99%

In search of drugs to alleviate suppression of the host's innate immune responses against SARS-CoV-2 using a molecular modeling approach

Choudhury

Moulick

Borah

et al. 2021

In Silico Pharmacol.

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Severe Acute Respiratory Syndrome coronavirus (SARS-CoV), Middle East Respiratory Syndrome coronavirus (MERS-CoV) and the novel SARS-CoV-2 evade the host innate immunity, and subsequently the adaptive immune response, employing one protease called Papain-like protease (PLpro). The PLpro and the 3CL main protease are responsible for the cleavage of the polyproteins encoded by the + sense RNA genome of the virus to produce several non-structured proteins (NSPs). However, the PLpro also performs deubiquitination and deISGylation of host proteins and signaling molecules, and thus antagonize the host innate immune response, since ubiquitination and ISGylation are critical processes which invoke host’s antiviral immune responses. Thus, to maintain host antiviral defense, inhibition of the PLpro is the primary therapeutic strategy. Furthermore, inhibition of the enzyme prevents replication of the virus. The present study employs molecular modeling approaches to determine potential of different approved and repurposed drugs and other compounds as inhibitors of the SARS-CoV-2 PLpro. The results of the study demonstrated that drugs like Stallimycin, and known protease inhibitors including Telaprevir, Grazoprevir and Boceprevir, were highly potent in inhibiting the enzyme. In addition, several plant-derived polyphenols, including Corylifol A and Kazinol J, were found to be potent inhibitors. Based on the findings, we suggest that clinical trials be initiated with these inhibitors. So far, PLpro inhibition has been given less attention as a strategy to contain COVID-19 pandemic, and thus the present study is of high significance and has therapeutic implications in containing the pandemic. Supplementary Information The online version contains supplementary material available at 10.1007/s40203-021-00085-y.

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Epidemiological, Clinical and Serological Characteristics of Children with Coronavirus Disease 2019 in Wuhan: A Single-centered, Retrospective Study

Cited by 4 publications

References 21 publications

Parkinsonism: An emerging post COVID sequelae

Parkinsonism: An emerging post COVID sequelae

Use of dual priming oligonucleotide system-based multiplex RT-PCR assay to detect five diarrhea viruses in pig herds in South China

In search of drugs to alleviate suppression of the host's innate immune responses against SARS-CoV-2 using a molecular modeling approach

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