Epidemiological, Clinical, Biological, Therapeutic Features and Outcome of Congenital Malaria at the Borgou Regional University Teaching Hospital (CHUD-B) in Benin in 2015

Abstract

Background: The prevalence of congenital malaria is getting more and more significant in Sub-Saharan Africa where is a malaria-endemic area. This study aimed to identify the clinical and therapeutic features as well as the outcome of congenital malaria in CHUD-B in 2015. Method: It was a cohort and descriptive study with analytical purpose, carried out in the Mother and Child Department which includes the Gynecology & Obstetrics and Pediatric Unit of CHUD-B. The study target population consisted of all the infants born in the CHUD-B as well as their mothers. The main variable was the presence of congenital malaria. The independent variables were those related to clinical, therapeutic features and outcome. Results: In the study, among the 300 newborns registered, 57 carried congenital malaria i.e. a prevalence of 19%. 171 (57.0%) of them were males versus 129 (43.0%) females. Among the 281 mothers involved, 48 presented with malaria in pregnancy i.e. a prevalence of 17.0%.At the end of this research work, the factors associated with congenital malaria were fever in the 3rd quarter and malaria in pregnancy in the mother. Conclusion: Nearly one out of five infants born in the CHUD-B was carrier of congenital malaria and approximately one out six mothers presented with malaria detection during pregnancy. A method based on Polymerase Chain Reaction (PCR) should be implemented during the diagnosis in order to confirm malaria cases among both newborns and mothers.

Congenital Malaria in Newborns Presented at Tororo General Hospital in Uganda: A Cross-Sectional Study

“…32 However, there was an association between maternal malaria parasitemia and congenital malaria in studies from Benin and Calabar, Nigeria. 19,33 Other previous studies have also reported multiple factors associated with congenital malaria, such us placental malaria, cord blood parasitemia, gravidity of one, and maternal age less than 19 years, as was the case in this study. 15,21,[34][35][36] We show that mothers who had malaria during pregnancy and who were treated with quinine were less likely to deliver newborns with congenital malaria.…”

Prevalence of Congenital Malaria in Kisangani, A Stable Malaria Transmission Area in Democratic Republic of the Congo

“…The prevalence of our study is also less than the one found by Lehner and Andrews [20] in Guinea (14.6%) and Obiajunwa et al [21] in Nigeria (54.2%). In Benin, Sagbo et al [22] found 57% of congenital malaria in newborns and 17.08% in those whose mothers had malaria during pregnancy. To diagnose congenital malaria, Sagbo et al [22] had considered the TDS and the malaria rapid test on the umbilical cord or peripheral blood of the newborn.…”

“…In Benin, Sagbo et al [22] found 57% of congenital malaria in newborns and 17.08% in those whose mothers had malaria during pregnancy. To diagnose congenital malaria, Sagbo et al [22] had considered the TDS and the malaria rapid test on the umbilical cord or peripheral blood of the newborn. Obiajunwa et al [21] found a strong association between placental malaria and cord parasitaemia.…”