Epidemiological concordance of Japanese encephalitis virus infection among mosquito vectors, amplifying hosts and humans in India

Borah, Jani; Dutta, Prafulla; Khan, Siraj Ahmed; Mahanta, Jagadish

doi:10.1017/s0950268812000258

Cited by 37 publications

(45 citation statements)

References 24 publications

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“…Domestic pigs serve as amplifying hosts for viruses while mosquitoes serve as the important vectors prior to transmission to humans (Borah et al 2013). Japanese encephalitis and Nipah viruses often affect pigs and pig-farm workers, as well as other pigfarming areas in Malaysia (Chua 2010).…”

Section: Introductionmentioning

confidence: 99%

First Report on Adulticide Susceptibility Status of Aedes albopictus, Culex quinquefasciatus, and Culex vishnui from a Pig Farm in Tanjung Sepat, Selangor, Malaysia

Low

Lee

Nazni

et al. 2013

Journal of the American Mosquito Control Association

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The present study aims to investigate the susceptibility status of Aedes albopictus, Culex quinquefasciatus, and Cx. vishnui collected from a pig farm in Tanjung Sepat, Selangor, toward 11 insecticides representing the classes of organochlorines, carbamates, organophosphates, and pyrethroids. The results of a World Health Organization adult mosquito bioassay revealed that Ae. albopictus, Cx. quinquefasciatus, and Cx. vishnui exhibited different susceptibility toward various insecticides. Overall, pyrethroids were able to induce rapid knockdown for all test mosquito species. The pyrethroids lambdacyhalothrin and etofenprox were able to cause high mortality (> 80%) of all 3 species. The findings of the present study will benefit local authorities in selecting appropriate dosage of insecticides to be used in mosquito control in this area.

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Section: Introductionmentioning

confidence: 99%

First Report on Adulticide Susceptibility Status of Aedes albopictus, Culex quinquefasciatus, and Culex vishnui from a Pig Farm in Tanjung Sepat, Selangor, Malaysia

Low

Lee

Nazni

et al. 2013

Journal of the American Mosquito Control Association

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“…JE is principally distributed in temperate and tropical areas of the Asia-Pacific Region, with an estimated worldwide annual incidence of nearly 70,000 clinical cases, resulting in upwards of 20,000 fatalities (4,5). Mosquitoes are the major vectors in JEV transmission in nature (6,7), but the interaction of JEV and the mosquito host, at the molecular level, is still unclear.…”

mentioning

confidence: 99%

mosGCTL-7, a C-Type Lectin Protein, Mediates Japanese Encephalitis Virus Infection in Mosquitoes

Liu

Qian

Jung

et al. 2017

J Virol

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Japanese encephalitis virus (JEV) is an arthropod-borne flavivirus prevalent in Asia and the Western Pacific and is the leading cause of viral encephalitis. JEV is maintained in a transmission cycle between mosquitoes and vertebrate hosts, but the molecular mechanisms by which the mosquito vector participates in transmission are unclear. We investigated the expression of all C-type lectins during JEV infection in Aedes aegypti. The C-type lectin mosquito galactose-specific C-type lectin 7 (mosGCTL-7) (VectorBase accession no. AAEL002524) was significantly upregulated by JEV infection and facilitated infection in vivo and in vitro. mosGCTL-7 bound to the N-glycan at N154 on the JEV envelope protein. This recognition of viral N-glycan by mosGCTL-7 is required for JEV infection, and we found that this interaction was Ca 2ϩ dependent. After mosGCTL-7 bound to the glycan, mosPTP-1 bound to mosGCTL-7, promoting JEV entry. The viral burden in vivo and in vitro was significantly decreased by mosPTP-1 double-stranded RNA (dsRNA) treatment, and infection was abolished by anti-mosGCTL-7 antibodies. Our results indicate that the mosGCTL-7/mosPTP-1 pathway plays a key role in JEV infection in mosquitoes. An improved understanding of the mechanisms underlying flavivirus infection in mosquitoes will provide further opportunities for developing new strategies to control viral dissemination in nature.IMPORTANCE Japanese encephalitis virus is a mosquito-borne flavivirus and is the primary cause of viral encephalitis in the Asia-Pacific region. Twenty-four countries in the WHO Southeast Asia and Western Pacific regions have endemic JEV transmission, which exposes Ͼ3 billion people to the risks of infection, although JEV primarily affects children. C-type lectins are host factors that play a role in flavivirus infection in humans, swine, and other mammals. In this study, we investigated C-type lectin functions in JEV-infected Aedes aegypti and Culex pipiens pallens mosquitoes and cultured cells. JEV infection changed the expression of almost all C-type lectins in vivo and in vitro, and mosGCTL-7 bound to the JEV envelope protein via an N-glycan at N154. Cell surface mosPTP-1 interacted with the mosGCTL-7-JEV complex to facilitate virus infection in vivo and in vitro. Our findings provide further opportunities for developing new strategies to control arbovirus dissemination in nature.

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“…28 More broadly, mosquito and virus surveillance systems combine vector data with climatic variables (temperature, rainfall, and tide height) and where appropriate sentinel animal seroconversions to create better calibrated predictive models of human disease risk. [34][35][36][37][38][39] In this study, we used a quantitative approach to assess individual mosquito trap sites in an attempt to improve and streamline surveillance. We found that mosquito abundance and RRV detection in mosquitoes were effective predictors of human RRV risk across the Peel region in south-west WA.…”

Section: Discussionmentioning

confidence: 99%

Mosquito and Virus Surveillance as a Predictor of Human Ross River Virus Infection in South-West Western Australia: How Useful Is It?

Walker

Jardine

Johansen

et al. 2018

The American Journal of Tropical Medicine and Hygiene

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Mosquito and virus surveillance systems are widely used in Western Australia (WA) to support public health efforts to reduce mosquito-borne disease. However, these programs are costly to maintain on a long-term basis. Therefore, we aimed to assess the validity of mosquito numbers and Ross River virus (RRV) isolates from surveillance trap sites as predictors of human RRV cases in south-west WA between 2003 and 2014. Using negative binomial regression modeling, mosquito surveillance was found to be a useful tool for predicting human RRV cases. In eight of the nine traps, when adjusted for season, there was an increased risk of RRV cases associated with elevated mosquito numbers detected 1 month before the onset of human cases for at least one quartile compared with the reference group. The most predictive urban trap sites were located near saltmarsh mosquito habitat, bushland that could sustain macropods and densely populated residential suburbs. This convergence of environments could allow enzootic transmission of RRV to spillover and infect the human population. Close proximity of urban trap sites to each other suggested these sites could be reduced. Ross River virus isolates were infrequent at some trap sites, so ceasing RRV isolation from mosquitoes at these sites or where isolates were not predictive of human cases could be considered. In future, trap sites could be reduced for routine surveillance, allowing other environments to be monitored to broaden the understanding of RRV ecology in the region. A more cost-effective and efficient surveillance program may result from these modifications.

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Epidemiological concordance of Japanese encephalitis virus infection among mosquito vectors, amplifying hosts and humans in India

Cited by 37 publications

References 24 publications

First Report on Adulticide Susceptibility Status of Aedes albopictus, Culex quinquefasciatus, and Culex vishnui from a Pig Farm in Tanjung Sepat, Selangor, Malaysia

First Report on Adulticide Susceptibility Status of Aedes albopictus, Culex quinquefasciatus, and Culex vishnui from a Pig Farm in Tanjung Sepat, Selangor, Malaysia

mosGCTL-7, a C-Type Lectin Protein, Mediates Japanese Encephalitis Virus Infection in Mosquitoes

Mosquito and Virus Surveillance as a Predictor of Human Ross River Virus Infection in South-West Western Australia: How Useful Is It?

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