Epidemiological, Diagnostic, Clinical, and Therapeutic Aspects of<i>Brucella</i>Bacteremia in Children in Southern Israel: A 7-Year Retrospective Study (2005–2011)

Fruchtman, Yariv; Wilkof-Segev, Renana; Golan, Agi; Dalem, Yael; Tailakh, Muhammad Abu; Novak, V.; Peled, Nir; Craiu, Mihai; Leibovitz, Eugene

doi:10.1089/vbz.2014.1726

Cited by 19 publications

(22 citation statements)

References 39 publications

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“…Children were also hospitalized for a longer duration. These hospitalization rates were higher than in previous reports, including studies from Israel, 1,2,14 and can be related to the increased concerns about complications in the setting of an epidemic and to the well-established superiority of aminoglycoside-containing regimens (given intravenously in hospitals to avoid repeated intramuscular injections) in decreasing relapse. Higher rates of osteoarticular manifestations in children may also account for longer hospitalizations.…”

Section: -10mentioning

confidence: 55%

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Brucellosis Outbreak in Children and Adults in Two Areas in Israel

Megged

Chazan

Ganem

et al. 2016

The American Society of Tropical Medicine and Hygiene

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Abstract. Two parallel outbreaks of Brucella melitensis infection occurred in 2014 in two geographical areas in Israel. In two medical centers in northern Israel and one medical center in Jerusalem, 102 patients (58 children, 47 adults) were diagnosed with brucellosis. Most patients (N = 76, 72%) were Muslim Arabs, 28 (27%) were Druze, and one was Jewish. The source of infection was often traced to cheese from the Palestinian Authority. Biovar-1 was evident in 98% in northern Israel but only in 42% in Jerusalem. Most common manifestations were fever (82%) and osteoarticular symptoms (49%). The major differences between the geographic areas were ethnicity and duration until diagnosis. Compared with adults, children had higher rates of hospitalization (93% versus 64%, P = 0.001), osteoarticular symptoms (60% versus 36%, P = 0.05), elevated alanine aminotransferase (12% versus 0%, P = 0.01), and lower C-reactive protein (2.28 ± 2.08 versus 5.57 ± 6.3l mg/dL, P = 0.001). Two unrelated brucellosis outbreaks occurred in 2014 in two different geographic areas of Israel and were limited to sections of the Arab and Druze populations. Most of the demographic and clinical aspects of patients were not affected by geographic variability. Clinical and laboratory differences were found between children and adults emphasizing the nonuniformity of the disease in different age groups. Effective control of unpasteurized dairy foods, health education programs, and improved regional cooperation are required to control brucellosis in Israel.

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Section: -10mentioning

confidence: 55%

“…[1][2][3] Most of human brucellosis cases in Israel are caused by ingestion of unpasteurized dairy products from infected animals. 3 The incidence of brucellosis ranges from 0.2/100,000 in the Jewish population to 7/100,000 among Arabs.…”

Section: Introductionmentioning

confidence: 99%

Brucellosis Outbreak in Children and Adults in Two Areas in Israel

Megged

Chazan

Ganem

et al. 2016

The American Society of Tropical Medicine and Hygiene

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“…Regarding Brucella spp. spinal infections, currently the most commonly used antibiotics are tetracycline, rifampicin, aminoglycosides, trimethoprim-sulfamethoxazole, and quinolones [ 68 ]. In children, considering the problems related to the use of quinolones and tetracycline, a combination of trimethoprim-sulfamethoxazole is recommended for approximately 3–6 months [ 69 ].…”

Section: Treatmentmentioning

confidence: 99%

Infectious Discitis and Spondylodiscitis in Children

Principi

Esposito

2016

IJMS

138

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In children, infectious discitis (D) and infectious spondylodiscitis (SD) are rare diseases that can cause significant clinical problems, including spinal deformities and segmental instabilities. Moreover, when the infection spreads into the spinal channel, D and SD can cause devastating neurologic complications. Early diagnosis and treatment may reduce these risks. The main aim of this paper is to discuss recent concepts regarding the epidemiology, microbiology, clinical presentation, diagnosis, and treatment of pediatric D and SD. It is highlighted that particular attention must be paid to the identification of the causative infectious agent and its sensitivity to antibiotics, remembering that traditional culture frequently leads to negative results and modern molecular methods can significantly increase the detection rate. Several different bacterial pathogens can cause D and SD, and, in some cases, particularly those due to Staphylococcus aureus, Kingella kingae, Mycobacterium tuberculosis, Brucella spp., the appropriate choice of drug is critical to achieve cure.

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“…4 In endemic regions for brucellosis, infections with this pathogen are frequent and osteoarticular involvement was described. 9,10 The diagnosis of SA caused by Brucella spp. is based on epidemiologic factors, high risk of suspicion, family history, serologic tests and blood and/or synovial fluid cultures.…”

Section: Introductionmentioning

confidence: 99%

Septic arthritis in children: Updated epidemiologic, microbiologic, clinical and therapeutic correlations

Cohen

Katz

Rahamim

et al. 2020

Pediatrics & Neonatology

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Background: Septic arthritis (SA) is an infection characterized by significant epidemiologic and microbiologic differences between developed and developing regions and between age groups. Objectives: To determine the epidemiologic, clinical, microbiologic and therapeutic aspects of pediatric SA in Southern Israel. Methods: A retrospective case-series study based on the records of children <16 years of age admitted with SA at Soroka Medical Center, Beer-Sheva, during 2006e2013. Results: 189 patients were enrolled. There were 119 (63%) Bedouin and 70 (37%) Jewish children. The knee (39.7%), hip (28%) and ankle (13.8%) were the most commonly involved joints. Blood and/or synovial fluid cultures were positive in 48 (25.4%) patients. Overall SA incidence among children <16 years and <5 years was 11.7 and 25.4/100,000, respectively, without changes throughout the study period. SA incidence among Bedouin children was higher than among Jewish children (15.4 vs. 8.3/100,000 cases). Staphylococcus aureus was the most commonly isolated pathogen (18,19.5% of all patients), followed by Kingella kingae (10, 5.3%)e(37.5% and 20.8% among culture-positive patients, respectively). The number of children with culture-positive SA that required surgery was higher than those with culturepositive SA treated conservatively (P < 0.001). Hospitalization was longer in children treated surgically than in those treated conservatively (P < 0.001).Conclusion: This study is the largest single-center series on pediatric SA published in the last five years and provided an updated picture on incidence and the microbiologic, clinical and

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Epidemiological, Diagnostic, Clinical, and Therapeutic Aspects ofBrucellaBacteremia in Children in Southern Israel: A 7-Year Retrospective Study (2005–2011)

Cited by 19 publications

References 39 publications

Brucellosis Outbreak in Children and Adults in Two Areas in Israel

Brucellosis Outbreak in Children and Adults in Two Areas in Israel

Infectious Discitis and Spondylodiscitis in Children

Septic arthritis in children: Updated epidemiologic, microbiologic, clinical and therapeutic correlations

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