Epidemiological Distribution of Nontuberculous Mycobacteria Using Geographical Information System

Farnia, Parissa; Farnia, Poopak; Ghanavi, Jalaledin; Velayati, Ali Akbar

doi:10.1016/b978-0-12-814692-7.00010-3

Cited by 5 publications

(2 citation statements)

References 133 publications

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“…Results from this review are consistent with other studies in which MAC particularly M. intracellulare was the most common isolated species in Tanzania, South Africa, Nigeria, South Korea and China (1,24,32,37,60,67) (68). In Africa Mycobacterium kansasii (636/ 8304; 7.65%), Mycobacterium intracellulare (2278/8304; 7.43%), Mycobacterium avium (611/8304; 7.35%), and Mycobacterium avium complex (517/8304; 6.22%) were the most frequent species among different countries (56).…”

Section: Species Identification Of Ntm In Humans In Zambiamentioning

confidence: 99%

Nontuberculous Mycobacteria in Humans, Animals, and Water in Zambia: A Systematic Review

et al. 2021

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Nontuberculous mycobacteria (NTM) are environmental opportunistic pathogens of humans and animals that are emerging with a serious public health impact particularly in individuals with Acquired Immunodeficiency Syndromes. Recent scientific evidence is shifting from NTMs being known as traditional environmental organisms to serious pathogenic organisms in both animals and humans. In humans, factors attributable to this rise have been linked mainly to Human Immunodeficiency Virus and Acquired Immunodeficiency Syndrome pandemic. In recent years there has been an increase in multidrug resistant Tuberculosis in Zambia and it is thought that NTMs could possibly be the cause. This study was therefore formulated to review available information on the prevalence of NTM in humans, animals and the environment, species distribution, zoonotic potential and public health importance in Zambia. This review was conducted in accordance with PRISMA guidelines. A literature search was done in PubMed and Google scholar using predefined search terms such as ‘nontuberculous mycobacteria’, ‘atypical mycobacteria’, ‘mycobacteria other than mycobacterium tuberculosis’ and ‘Zambia’, in combination with Boolean operators (AND, OR). This particular systematic review draws findings based on literature search between 2000 and 2020. Through literature search 243 papers were identified, 23 duplicates were identified and removed and 206 articles were excluded as they did not meet the inclusion criteria. The full text of the remaining 14 articles were considered for this review. The overall prevalence of NTM in humans was 24.39%, in water 21.5%, in animals 16.05% of which the prevalence in cattle was 14.81% and Kafue Lechwe 1.23%. Mycobacterium intracellulare was the most common isolated nontuberculous mycobacteria in humans and cattle while Mycobacterium gordonae was the most common in water, and Mycobacterium stomatepiae sp Nov in Kafue Lechwe. Nontuberculous mycobacteria are an emerging public health threat in Zambia both in humans and animals and this calls for the need for molecular information on the zoonotic transmission of nontuberculous mycobacteria. Increased awareness of nontuberculous mycobacteria diseases among clinicians and laboratory personnel is crucial for patient management and an essential step for facilitating the identification of nontuberculous mycobacteria species in laboratories.

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Section: Species Identification Of Ntm In Humans In Zambiamentioning

confidence: 99%

Nontuberculous Mycobacteria in Humans, Animals, and Water in Zambia: A Systematic Review

et al. 2021

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“…The MAC was the most common NTM detected. The predominance of MAC has been reported in pulmonary NTM infections in many countries around the world (26,27,40,41) 29,38,40,41. In Mali, between 2004 and 2013, M. avium was the most frequently identified species of the MAC complex (7,27,37).…”

Section: Discussionmentioning

confidence: 91%

Prevalence of non-tuberculous mycobacteria among people presumed to have tuberculosis, positive for acid-fast bacilli in Mali

Cisse,

Dean,

Van Deun

et al. 2024

Preprint

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Background: Non-tuberculosis mycobacteria (NTMs) are environmental agents that can cause opportunistic pulmonary disease in humans and animals which is often misdiagnosed as tuberculosis (TB). In this study, we describe the cases of NTMs identified during the first national anti-TB drug-resistance survey conducted in Mali, and associated risk factors. Methods: Sputum was collected from people presenting for pulmonary TB diagnosis, from April to December 2019, regardless of age. Microscopy-positive patients were enrolled and were tested by GeneXpert MTB/RIF. Cases that tested negative for the Mycobacterium tuberculosis complex (MTBc) were tested for presence of mycobacteria by amplification of the IS6110 and 16SrRNA genes through double quantitative real-time PCR, followed by nested PCR and Sanger sequencing of the IS6110-negative samples for NTM species identification. Results: A total of 1,418 sputum smear-positive patients were enrolled, including 1,199 new cases, 211 previously treated cases and 8 whose previous treatment history was unknown. Based on the results of GeneXpert MTB/RIF and in-house PCR methods, 1331 (93.9%) patients were positive for MTBc, 48 (3.4%) for NTMs and for 39 (2.7%) no species identification was possible. Advanced age (65 and over) (OR 8.8, p=0.001) and previous TB treatment (OR 3.4 and p=0.016) were the risk factors statistically associated with NTM detection. M. avium complex (MAC) was the predominant NTM species, detected in 20 cases. Conclusion: Detection of NTMs in people presumed to have TB is an ongoing challenge, confounding correct TB diagnosis. Concomitant use of microscopy and GeneXpert testing among at-risk individuals could lessen confusion.

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Nontuberculous Mycobacteria Infection: Source and Treatment

Hutchison

Waller

2019

Curr Pulmonol Rep

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Epidemiological Distribution of Nontuberculous Mycobacteria Using Geographical Information System

Cited by 5 publications

References 133 publications

Nontuberculous Mycobacteria in Humans, Animals, and Water in Zambia: A Systematic Review

Nontuberculous Mycobacteria in Humans, Animals, and Water in Zambia: A Systematic Review

Prevalence of non-tuberculous mycobacteria among people presumed to have tuberculosis, positive for acid-fast bacilli in Mali

Nontuberculous Mycobacteria Infection: Source and Treatment

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