Epidemiological Evidence from Chemical and Spectrographic Analyses that Soil is Concerned in the Causation of Cancer

Stocks, Percy; Davies, Rob

doi:10.1038/bjc.1960.2

Cited by 37 publications

(7 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…But it is important to note that the exciting geographical variations in stomach cancer so widely reported for Iceland in the 1960s were probably false. At the time of the trace element study in Iceland, the elements that were believed to be associated with stomach cancer were excesses of zinc and cobalt (Stocks and Davies, 1960) and deficiency of copper (Voisin, 1959). In the early seventies attention shifted to selenium and a hypothesis that as a micronutrient this element had a protective effect for some cancers (Shamberger and Willis, 1971).…”

Section: Discussionmentioning

confidence: 99%

“…In 1962 there was considerable interest in possible relationships between trace elements in soils and stomach cancer, for example, Stocks and Davies (1960), Tromp andDiehl (1955), andVoisin (1959). Iceland offered an excellent site to test hypotheses about these relationships because of very high incidence of stomach cancer (65 per 100,000 per year in males and 35 in females, 1959-61), a comparatively simple diet that relied heavily on meat and vegetables raised on local soils, and excellent medical and pathological records dating from 1920.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Follow-up on a 1962 case-control study of trace elements as risk factors for stomach cancer in Iceland

1990

Environ Geochem Health

View full text Add to dashboard Cite

In 1988 a follow-up investigation was made of a case-control study conducted in 1962 in Iceland which tested hypotheses that trace elements in pasture grass, drinking water and cow's milk were associated through diet with cancer of the stomach. Samples were collected in 1962 from 26 farms in the northern county of Skagafjardarsysla and 30 farms in the southern county of Rangarvallasysla. The main objective of the present study was to establish the cancer experience of the 297 residents of the 56 farms since 1962. In the records of the Icelandic Cancer Registry 31 cases of cancer of all types were identified. Six were cancers of the stomach and four of these were from control farms. The revised comparison of trace element analyses for case and control farms yielded no change in earlier results for pasture grass in Skagafjardarsysla (excess levels of B, Na, AI, Fe and Cu on cancer farms), but B appeared as a significant deficiency on cancer farms in Rangarvallasysla. Drinking water results were unchanged (no significant differences), but for milk the significantly high mean values of Fe and Zn reported earlier for Rangarvallasysla did not appear. The pronounced geographical variation in Icelandic stomach cancer incidence that was widely cited from 1961-65 is now believed to have been spurious.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Follow-up on a 1962 case-control study of trace elements as risk factors for stomach cancer in Iceland

1990

Environ Geochem Health

View full text Add to dashboard Cite

show abstract

“…39 Yet, even in England and Eire exist pronounced differences in the content and distribution of selenium in soils and in plants. Elevated levels have been reported in the soil of County Limerick, Meath and Tipperary in Eire, and in Staffordshire and Devon in England; the levels of selenium found in soil were up to 90 ppm, and in some plants up to 108 ppm 4l)i41 in certain localities.…”

Section: Relevant Factors In China and Elsewherementioning

confidence: 99%

Environmental factors and cancer of the oesophagus. the role of seleniferous soils and trichothecene mycotoxins ‐ a hypothesis

Schoental

1983

International Journal of Environmental Studies

View full text Add to dashboard Cite

Online) Journal homepage: http://www.tandfonline.com/loi/genv20 Environmental factors and cancer of the oesophagus. the role of seleniferous soils and trichothecene mycotoxins -a hypothesis R. Schoental To cite this article: R. Schoental (1983) Environmental factors and cancer of the oesophagus. the role of seleniferous soils and trichothecene mycotoxins -a hypothesis, International Journal of Environmental Studies, 21:2, 159-164,Evidence is presented that oesophageal cancer in some high-risk areas may be related to seleniferous soils and to the irritant trichothecene mycotoxins.

show abstract

“…Most of these recent studies have confined their attention to a specific disease in a selected community. In the case of cancer, for example, Stocks and Davies (1960) analyzed soil elements in samples from 300 home gardens in Wales and England and found high levels of chromium, zinc, cobalt, and organic matter associated with mortality from cancer of the stomach. However, in rural Iceland, among a small group of matched cases and controls, Armstrong (1964; found no consistent relationships between mortality from stomach cancer and the trace element contents of samples of pasture grass, milk, and drinking water.…”

Section: Geographical Associationsmentioning

confidence: 99%

Medical Geography and Its Geologic Substrate

Armstrong

1971

Geological Society of America Memoirs

View full text Add to dashboard Cite

Geographical associations between geochemical variables and the occurrence of certain human diseases have been pointed out for several decades.Associations between distributions of elements in soil and water and distributions of mortality from cardiovascular disease, multiple sclerosis, and certain cancers, have been particularly strong and persistent over time. Results of analytical studies have so far been inconclusive. Other relationships, apart from the geochemical, may be more important. A comparison of county distributions in Norway, Sweden and the Netherlands for a number of environmental variables, and prevalence of multiple sclerosis is presented. It is suggested that an ecological approach to the possible geochemical association with disease is critical, and that more attention could be given to that side of the relationship concerned with man. CONTENTS

show abstract

Epidemiological Evidence from Chemical and Spectrographic Analyses that Soil is Concerned in the Causation of Cancer

Cited by 37 publications

References 2 publications

Follow-up on a 1962 case-control study of trace elements as risk factors for stomach cancer in Iceland

Follow-up on a 1962 case-control study of trace elements as risk factors for stomach cancer in Iceland

Environmental factors and cancer of the oesophagus. the role of seleniferous soils and trichothecene mycotoxins ‐ a hypothesis

Medical Geography and Its Geologic Substrate

Contact Info

Product

Resources

About