Epidemiological features and disease-related concerns of a large cohort of Italian patients with active Crohn’s disease

Armuzzi, Alessandro; Riegler, G.; Furfaro, Federica; Baldoni, Monia; Costa, Francesco; Fortuna, M; Iaquinto, Gaetano; Paese, Pietro; Papi, Claudio; Bossa, Fabrizio; Tontini, Gian Eugenio; Fino, Sara Di; Gualberti, Giuliana; Merolla, Rocco; Rizzello, Fernando

doi:10.1016/j.dld.2018.12.019

Cited by 5 publications

(1 citation statement)

References 37 publications

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“…Annually, 2000 (0.66%) of these in the UK (1) and an estimated 24,000 (1.5%) in the USA (2) undergo surgery resulting in a permanent or temporary stoma. Fear of having a stoma is repeatedly reported as a major concern for people with IBD in many countries (3)(4)(5)(6)(7)(8), alongside fatigue, disease and bowel control, and disease unpredictability (4;5;9) but there is no evidence to explain this level of concern. There is minimal evidence on the experience of living with a stoma for IBD or why people are so fearful of stoma-forming surgery (SFS) that they are willing to trade life expectancy to avoid it (10).…”

Section: Introductionmentioning

confidence: 99%

Patient Decision-Making About Emergency and Planned Stoma Surgery for IBD: A Qualitative Exploration of Patient and Clinician Perspectives

Dibley

Czuber‐Dochan

Wade

et al. 2018

Inflammatory Bowel Diseases

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Section: Introductionmentioning

confidence: 99%

Patient Decision-Making About Emergency and Planned Stoma Surgery for IBD: A Qualitative Exploration of Patient and Clinician Perspectives

Dibley

Czuber‐Dochan

Wade

et al. 2018

Inflammatory Bowel Diseases

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Work Productivity Impairment in Persons with Inflammatory Bowel Diseases: A Systematic Review and Meta-analysis

Youssef,

Hossein-Javaheri,

Hoxha

et al. 2024

Journal of Crohn's and Colitis

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Background and Aims The impact of inflammatory bowel disease (IBD) on work productivity remains unclear. In this systematic review and meta-analysis, we quantify work-related outcomes and employment data among persons with IBD. Methods A systematic literature search was conducted in MEDLINE, EMBASE, the Cochrane library, Scopus, ProQuest, and clinicaltrials.gov from inception to February 2023 to identify studies on work productivity in persons with IBD aged >18 years. Work productivity was defined primarily by the Work Productivity and Activity Impairment (WPAI) questionnaire which includes absenteeism, presenteeism, overall work impairment, and non-work activity impairment. In addition, we included data on employment, sick leaves, disability pensions, and indirect costs due to productivity loss. Pooled effect analysis was conducted using a random-effects model for pooled estimates of continuous and proportional data with 95% confidence intervals. Results Among all patients with IBD, the pooled estimates were 16.4% for absenteeism, 35.9% for presenteeism, 39.4% for overall work impairment, and 46.0% for non-work activity impairment. Indirect costs from overall work impairment were 5,131.09 euros/patient/year. Only two thirds of IBD patients were employed and 1 in 3 patients lost their jobs due to IBD. Among those employed, 39.5% report sick days, 21.3% report work disability, and 12.3% receive disability pensions. Most studies demonstrate clinically meaningful improvements in work productivity with medical and/or surgical therapies. Conclusion Persons with IBD experience significant work impairment and associated indirect costs. This highlights the need for appropriate workplace accommodations and timely medical therapy to alleviate the burden of disease and improve work outcomes.

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Systematic Review and Meta-analysis on the Incidence, Prevalence and Determinants of Discomfort in Inflammatory Bowel Disease

Nistor

Godfrey

Ross‐White

et al. 2021

Journal of the Canadian Association of Gastroenterology

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Background The symptom burden in inflammatory bowel disease (IBD) has a significant negative impact on the health-related quality of life (HRQOL). Patients with IBD report physical, psychological and social discomfort even during remission. Aim To synthesize the best available evidence to determine the worldwide incidence, prevalence and determinants of discomfort in adults with inflammatory bowel disease (IBD). Methods Following PRISMA recommendations, we searched the Medline, CINAHL, PsycInfo, Embase, Cochrane, Campbell and JBI Evidence Synthesis databases for studies on either incidence or prevalence of discomfort in English until January 2021. Data were extracted using the Joanna Briggs Institute’s standardized extraction tools. Data that directly reported or could be used to calculate the incidence and prevalence of discomfort were extracted. Ten studies were eligible for inclusion in this review. Overall, the methodological quality of the included studies was considered moderate. Data measuring the incidence of discomfort in 6 out of 10 identified studies using the same measurement tool (EQ-5D) were pooled in a meta-analysis. Additional results have been presented in a narrative form, including tables. Results There is no standardized definition or tool utilized to describe or measure discomfort in IBD. Synthesized findings demonstrate that discomfort is prevalent among adults living with IBD. Determinants of discomfort included health literacy, disease activity, hospitalization/surgery, age and gender, delayed diagnosis, local practice standards and quality of IBD care. Conclusions More research is needed to identify the impact of discomfort on health-related outcomes for people with IBD and consequently appraise discomfort interventions for their efficacy.

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Epidemiological features and disease-related concerns of a large cohort of Italian patients with active Crohn’s disease

Cited by 5 publications

References 37 publications

Patient Decision-Making About Emergency and Planned Stoma Surgery for IBD: A Qualitative Exploration of Patient and Clinician Perspectives

Patient Decision-Making About Emergency and Planned Stoma Surgery for IBD: A Qualitative Exploration of Patient and Clinician Perspectives

Work Productivity Impairment in Persons with Inflammatory Bowel Diseases: A Systematic Review and Meta-analysis

Systematic Review and Meta-analysis on the Incidence, Prevalence and Determinants of Discomfort in Inflammatory Bowel Disease

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