Epidemiological Features of Nosocomial Bloodstream Infections in Pediatric Patients

Gündoğdu, Aycan; Kılıç, Hüseyin; Ulu-Kılıç, Ayşegül; Aydin, Gunsu; Alp, Emine

doi:10.5152/kd.2016.07

Cited by 3 publications

(1 citation statement)

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“…17 18 This burden is largely attributed to MDROs 19 of which ESKAPE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter spp) pathogens play a significant role. [20][21][22][23] In recent years, scientists have suggested the inclusion of Clostridioides (Clostridium) difficile as a member of the ESKAPE pathogens and subsequently amending the acronym to ESCAPE pathogens. 24 Significant efforts have been made to reduce the burden of HCAIs and AMR, but the problem persists.…”

Section: Strengths and Limitations Of This Studymentioning

confidence: 99%

Antimicrobial stewardship and infection prevention interventions targeting healthcare-associatedClostridioides difficileand carbapenem-resistantKlebsiella pneumoniaeinfections: a scoping review

2021

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ObjectivesThis study assessed antimicrobial stewardship (AMS) and infection prevention (IP) interventions targeting healthcare-associated Clostridioides difficile and carbapenem-resistant Klebsiella pneumoniae (CRKP) infections, their key outcomes and the application of behaviour change principles in these interventions.DesignThis scoping review was conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-analysis Extension for Scoping Reviews (PRISMA-ScR) guidelines while focusing on acute healthcare settings in both low-to-middle income and high-income countries.Data sourcesThe databases searched were MEDLINE, PubMed, Web of Science and CINAHL between 22 April 2020 and 30 September 2020.EligibilityThe review included peer-reviewed articles published in English language between 2010 and 2019. Studies that focussed on IP and/or AMS interventions primarily targeting C. difficile or CRKP were included. Studies that assessed effectiveness of diagnostic devices or treatment options were excluded from this review.Data extraction and synthesisAn abstraction sheet calibrated for this study was used to extract data on the main study characteristics including the population, intervention and outcomes of interest (antimicrobial use, compliance with IP interventions and risk for C. difficile and CRKP). A narrative synthesis of the results is provided.ResultsThe review included 34 studies. Analysis indicates that interventions targeting C. difficile and CRKP include Education, Surveillance/Screening, Consultations, Audits, Policies and Protocols, Environmental measures, Bundles, Isolation as well as Notifications or alerts (represented using the ESCAPE-BIN acronym). The identified outcomes include antimicrobial use, resistance rates, risk reduction, adherence to contact precautions, hospital stay and time savings. AMS and IP interventions tend to be more adhoc with limited application of behaviour change principles.ConclusionThis scoping review identified the AMS and IP interventions targeting C. difficile and CRKP in healthcare settings and described their key outcomes. The application of behaviour change principles in AMS and IP interventions appears to be limited.

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Section: Strengths and Limitations Of This Studymentioning

confidence: 99%

Antimicrobial stewardship and infection prevention interventions targeting healthcare-associatedClostridioides difficileand carbapenem-resistantKlebsiella pneumoniaeinfections: a scoping review

2021

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Antibiotics resistance and mitigation strategies in healthcare settings: A scoping review

Okeah

Huws

Morrison

2020

Preprint

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Background: According to the European Center for Disease Prevention and Control (ECDC), the EU records an estimated 3.2 million healthcare associated infections (HAIs) and an associated 37,000 deaths annually. A significant proportion of the HAIs burden is attributable to multi-drug resistant pathogens. Infectious diseases remain top on the list of the leading causes of death globally with multi-drug resistant microorganisms (MDROs) playing a significant role. Aims: To assess the breadth of studies on antibiotics stewardship C. diff and Klebsiella pneumoniae in healthcare settings. To identify existing literature on the interventions for reducing healthcare associated C. diff and Klebsiella pneumoniae transmission. Methods: This scoping review was undertaken and reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analysis Protocols (PRISMA-P) guidelines. The specific databases searched included MEDLINE, PubMed, Web of Science Core Collection, and CINAHL. The process for screening articles and data extraction was undertaken in duplicate by two reviewers. A narrative synthesis of the results is provided. Results: The review included 34 studies (16 studies on Clostridium difficile and 18 articles focussed on Klebsiella pneumoniae). These interventions include Education, Surveillance/Screening, Consultations, Audits, Policies/Protocols, Environmental disinfection, Bundles, Isolation, and Notifications or alerts (ESCAPE-BIN). A study involving screening, alerts, staff education, and antimicrobial protocols recorded a 75% reduction in the use of targeted antimicrobials. The largest absolute reduction in antimicrobial use of 310 DDs/1000PDs was reported from an intervention that involved audits and feedback systems. The highest improvement (95%) in adherence was reported by an intervention involving the use of an infection prevention bundle and an environmental cleaning protocol. Conclusion: Antimicrobial resistance represents a global threat requiring urgent measures to protect lives. Reducing the burden of AMR entails a host of multi-level approaches aimed at curbing transmission of the resistant pathogens, and optimizing the use of antibiotics.

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Kahramanmaraş Sütçü İmam Üniversitesi Sağlık Uygulama ve Araştırma Hastanesi’nde Kan Kültürlerinden İzole Edilen Mikroorganizmalar ve Antibiyotik Duyarlılıkları

Küçük¹,

Arican²,

Gülderen³

et al. 2019

Sakarya Medical Journal

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Orcid :Burak Küçük: https://orcid.org/0000-0001-5596-3347 Gökhan Arıcan: https://orcid.org/0000-0002-2002-1904 Damla Gülderen: https://orcid.org/0000-0002-6645-9266Hacer Uğurlu: https://orcid.org/0000-0001-6126-5502 Kezban Tülay Yalçınkaya: https://orcid.org/0000-0002-6324-4585Murat Aral: https://orcid.org/0000-0002-3576-4380 ARAŞTIRMA MAKALESİ / Research Article Öz Amaç Kan dolaşımı enfeksiyonları, mortalite ve morbiditenin önde gelen nedenlerinden biridir. Çalışmamızın amacı kan kültürlerinde en sık belirlenen enfeksiyon etkenlerini ve antibiyotik duyarlılıklarını saptamaktır. ( Sakarya Tıp Dergisi 2019, 9(3):485-491 ) Gereç ve Yöntemler 1 Ocak 2018 -31Aralık 2018 tarihleri arasında çalışılan 3719 izolat çalışmaya dahil edilmiştir. Kan kültürü örnekleri BACT/ALERT 3D otomatize sistemi ile inkübe edilmiştir. Üreyen mikroorganizmaların identifikasyonu ve antibiyotik duyarlılıkları Phoenix otomatize sistem ile yapılmıştır Bulgular Çalışmaya dahil edilen 3719 kan kültürü örneğinin 2822'sinde (%75.8) Gram pozitif bakterilerin, 584'ünde (%16.7) Gram negatif bakterilerin, 180'inde (%4.8) mayaların ürediği görülmüştür. En sık izole edilen Gram negatif bakteriler Escherichia coli 227 (%36.37), Klebsiella pneumoniae 126 (%20.19) olarak bulunmuştur. Gram pozitif bakterilerin 2245'inin koagülaz negatif Staphylococcus türleri, 251'inin (%8.8) Enterococcus spp., 194'ünün (%6.87) Staphylococcus aureus olduğu saptanmıştır. Gram negatif bakterilere en etkili antibiyotikler karbapenemler, aminoglikozidler ve tigesiklin olarak bulunmuştur. Tüm Acinetobacter izolatları karbapenemlere dirençli bulunmuştur. Staphylococcus aureus izolatlarında vankomisin direnci saptanmazken metisilin direnci %55, koagülaz negatif Staphylococcus izolatlarında metisilin direnci %84 olarak bulunmuştur. Enterococcus spp. izolatlarında vankomisin direnci %9.7 olarak bulunmuştur Sonuç Sonuç olarak bakterilerin direnç oranlarının bu denli yüksek olması enfeksiyon kontrol önlemlerinin artırılması gerektiğini düşündürmektedir Anahtar Kelimeler AbstractObjective Blood stream infections remain a major cause of morbidity and mortality. The aim of this study is to determine the types of microorganisms and antibiotic susceptibility isolated from blood cultures. ( Sakarya Med J 2019, 9(3):485-491 ). Materials and Methods3719 isolates which were studied between 1 January 2018 -31 December 2018, identified included in the study. Blood culture samples were incubated in BACT/ALERT 3D automated system. Identification and antibiotic susceptibility of microorganisms were done with Phoenix automated system. ResultsOf the isolated 3719 microorganisms, 2822 (75.8%) were Gram positive, 584 (16.7%) were Gram negative, 180 (4.8%) were yeasts. The most frequent Gram negative bacteria were Escherichia coli 227 (36.3%), Klebsiella pneumoniae 126 (20.1%). The most frequent Gram positive bacteria were 2245 (79.5%) coagulase negative Staphylococcus, 251 (8.8%) Enterococcus spp., 194 (6.87%) Staphylococcus aureus. Carbapenems, aminoglycosides and tigecycline were most effective antib...

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Epidemiological Features of Nosocomial Bloodstream Infections in Pediatric Patients

Cited by 3 publications

References 8 publications

Antimicrobial stewardship and infection prevention interventions targeting healthcare-associatedClostridioides difficileand carbapenem-resistantKlebsiella pneumoniaeinfections: a scoping review

Antimicrobial stewardship and infection prevention interventions targeting healthcare-associatedClostridioides difficileand carbapenem-resistantKlebsiella pneumoniaeinfections: a scoping review

Antibiotics resistance and mitigation strategies in healthcare settings: A scoping review

Kahramanmaraş Sütçü İmam Üniversitesi Sağlık Uygulama ve Araştırma Hastanesi’nde Kan Kültürlerinden İzole Edilen Mikroorganizmalar ve Antibiyotik Duyarlılıkları

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