Epidemiological investigation of esophageal carcinoma

Zhang, Hong

doi:10.3748/wjg.v10.i12.1834

Cited by 28 publications

(19 citation statements)

References 13 publications

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“…43,52 However, further increases in the prevalence of overweight and obesity in China 46 is likely to be associated with increased mortality from various conditions, especially cardiovascular disease. 53 The rate of esophageal adenocarcinoma mortality may also rise consequently, 54 and this alone could potentially offset any advantageous effects of improved population nutrition on squamous cell carcinoma.…”

Section: Discussionmentioning

confidence: 99%

Esophageal cancer and body mass index: Results from a prospective study of 220,000 men in China and a meta‐analysis of published studies

Smith

Zhou

Whitlock

et al. 2008

Intl Journal of Cancer

124

130

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Several epidemiological studies have reported on the association between body mass index (BMI) and risk of esophageal cancer, but these were mostly in Western populations where many are overweight or obese. There is little direct evidence about the relationship in China where the mean BMI is relatively low and the disease rate is high. We examined the data from a populationbased prospective study of 220,000 Chinese men aged 40-79 without a previous history of cancer (mean BMI 21.7 kg/m 2 ), which included 1,082 esophageal cancer deaths during 10 years of follow-up. Adjusted hazard ratios for death from esophageal cancer by baseline BMI category were calculated using Cox proportional hazards models. Even among men with good self-assessed health and BMI 18.5 kg/m 2 , there was a strong inverse association between BMI and death from esophageal cancer, with each 5 kg/ m 2 higher BMI associated with 25% (95%CI: 11-36%) lower esophageal cancer mortality. This inverse association persisted when analysis was restricted to men who had never smoked or when the first 5 years of follow-up were excluded. The strength of the relationship was consistent with the pooled estimate for squamous cell carcinoma of the esophagus in a meta-analysis of prospective studies (31% lower relative risk per 5 kg/m 2 higher BMI; 95% CI: 25-37%), but contrasted with that for adenocarcinoma which showed a positive association with BMI. Together, these data provide reliable evidence that in many populations low BMI is associated with an increased risk of squamous cell carcinoma of the esophagus. ' 2007 Wiley-Liss, Inc.

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Section: Discussionmentioning

confidence: 99%

Esophageal cancer and body mass index: Results from a prospective study of 220,000 men in China and a meta‐analysis of published studies

Smith

Zhou

Whitlock

et al. 2008

Intl Journal of Cancer

124

130

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“…2 Results of epidemiologic researches indicate that the incidence of symptomatic OA is about 8 -9% in China. 3,4 OA is a multifactorial disorder in which aging, genetic, hormonal and mechanical factors are major contributors to its onset and progression, but the molecular mechanism underlying the cartilage degeneration is still largely unknown.…”

Section: Introductionmentioning

confidence: 99%

Mutation analysis of the Smad3 gene in human osteoarthritis

Yao

Wang

et al. 2003

Eur J Hum Genet

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Osteoarthritis (OA) is the most common joint disease worldwide. Recent studies have shown that targeted disruption of Smad3 in mouse results in OA. To reveal the possible association between the Smad3 gene mutation and human OA, we employed polymerase chain reaction-single strand conformation polymorphism and sequencing to screen mutations in all nine exons of the Smad3 gene in 32 patients with knee OA and 50 patients with only bone fracture. A missense mutation of the Smad3 gene was found in one patient. The single base mutation located in the linker region of the SMAD3 protein was A-T change in the position 2 of codon 197 and resulted in an asparagine to isoleucine amino-acid substitution. The expressions of matrix metalloproteinase 2 (MMP-2) and MMP-9 in sera of the patient carrying the mutation were higher than other OA patients and controls. This is the first report showing that the Smad3 gene mutations could be associated with the pathogenesis of human OA.

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“…ESCC mainly appears as chronic inflammation, acute abnormality, carcinoma in situ and invasive carcinoma, with a gradual evolution (Kuwano et al, 1993;Zhang et al, 2009). At present, ESCC in the majority of patients is diagnosised as advanced metastatic cancer of which the 5-year survival rate is less than 10% (Zhang et al, 2004). Therefore, it is of great importance to find metastasis-related genes for diagnosing ESCC.…”

Section: Introductionmentioning

confidence: 99%

Effects of Down-regulation of HDAC6 Expression on Proliferation, Cell Cycling and Migration of Esophageal Squamous Cell Carcinoma Cells and Related Molecular Mechanisms

Xiaojing²,

Liu³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Epidemiological investigation of esophageal carcinoma

Abstract: AIM:To review the characteristics of esophageal carcinoma in recent 30 years in the epidemiological investigation.

Cited by 28 publications

References 13 publications

Esophageal cancer and body mass index: Results from a prospective study of 220,000 men in China and a meta‐analysis of published studies

Esophageal cancer and body mass index: Results from a prospective study of 220,000 men in China and a meta‐analysis of published studies

Mutation analysis of the Smad3 gene in human osteoarthritis

Effects of Down-regulation of HDAC6 Expression on Proliferation, Cell Cycling and Migration of Esophageal Squamous Cell Carcinoma Cells and Related Molecular Mechanisms

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