Epidemiological investigation on chronic copper toxicity to children exposed via the public drinking water supply

Zietz, Björn P.; Dieter, Hermann H.; Lakomek, M.; Schneider, H. H.; Keßler-Gaedtke, Barabara; Dunkelberg, H

doi:10.1016/s0048-9697(02)00399-6

Cited by 186 publications

(88 citation statements)

References 23 publications

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“…For example, the Ely Copper Mine in Vermont is included on the Long Term/ National Priority List of Superfund sites (US EPA ID VTD98836657). Although an essential dietary element for some plants and animals, high concentrations of Cu in water can be toxic to fish and other aquatic species (25). There is currently no incentive to eliminate Cu in electronic products.…”

Section: Resultsmentioning

confidence: 99%

Leaching Assessments of Hazardous Materials in Cellular Telephones

Lincoln

Ogunseitan

Shapiro

et al. 2007

Environ. Sci. Technol.

114

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Protocols for assessing the risks of discarded electronic products (e-waste) vary across jurisdictions, complicating the tasks of manufacturers and regulators. We compared the Federal Toxicity Characteristic Leaching Procedure (TCLP), California's Waste Extraction Test (WET), and the Total Threshold Limit Concentration (TTLC) on 34 phones to evaluate the consistency of hazardous waste classification. Our sample exceeded TCLP criteria only for lead (average ) 87.4 mg L -1 ; range ) 38.2-147.0 mg L -1 ; regulatory limit ) 5.0 mg L -1 ), but failed TTLC for five metals: copper (average 203 g kg -1 ; range ) 186-224 g kg -1 ; limit ) 2.50 g kg -1 ), nickel (9.25 g kg -1 ; range ) 6.34-11.20 g kg -1 ; limit ) 2.00 g kg -1 ), lead (10.14 g kg -1 ; range ) 8.22-11.60 g kg -1 ; limit ) 1.00 g kg -1 ), antimony (1.02 g kg -1 ; range ) 0.86-1.29 g kg -1 ; limit ) 0.50 g kg -1 ), and zinc (11.01 g kg -1 ; range ) 8.82-12.80 g kg -1 ; limit ) 5.00 g kg -1 ). Thresholds were not exceeded for WET. We detected several organic compounds, but at concentrations below standards. Brominated flame retardants were absent. These results improve existing environmental databases for e-waste and highlight the need to review regulatory testing for hazardous waste.

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Section: Resultsmentioning

confidence: 99%

Leaching Assessments of Hazardous Materials in Cellular Telephones

Lincoln

Ogunseitan

Shapiro

et al. 2007

Environ. Sci. Technol.

114

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“…High concentrations of copper in drinking water are hazardous to human health (Barranguet et al 2003). Some cases of liver damage of children have been proved to be associated with the excessive intake of copper (Zietz et al 2003). Moreover, high concentrations of copper may destroy the biological reprocessing systems in water (Zhao et al 2009).…”

Section: Hgmentioning

confidence: 99%

Detection of heavy metals (Cu+2, Hg+2) by biosynthesized silver nanoparticles

2015

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Here, we are reporting two methods for detection of Cu ?2 ion and Hg ?2 ions using biosynthesized silver nanoparticles. The detection of Cu ?2 ion was based on changes in absorbance resulting from complex formation of the metal ion. Various concentrations of Cu ?2 ion were used to test the linearity and sensitivity of the method. A new peak at around 770 nm, in addition to the peak of the AgNP at 406 nm, was observed in each case (above 20 lM). With the increase of concentration of Cu ?2 ion solution, the absorbance at 406 nm peak decreased and that of 770 nm increased gradually. The calibration curve obtained from the ratio of the absorption coefficients of these two peaks (Ex 770/406 ) versus concentration of Cu ?2 ions enables one to estimate quantitatively the amount of Cu ?2 ions present in water in lM levels. This AgNP was further functionalized with 3-mercapto-1, 2-propanediol (MPD) for detection of Hg ?2 present in water by colorimetric method. As soon as Hg ?2 solution was added in MPDfunctionalized AgNP (MPD-AgNP), a new peak at around 606 nm appeared along with the peak at 404 nm. The new peak might be due to the aggregations occurred by the recognition of heavy metal ion Hg ?2 by MPD-AgNP through dipropionate ion. A calibration curve between the ratios of the absorption coefficients of these two peaks (Ex 404/606 ) and concentration of Hg ?2 was drawn for quantitative estimation of Hg ?2 present in water at lM level.

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“…1 However, if the Cu intake exceeds the range of biological tolerance, it can exert toxic side effects, including kidney damage, hemolysis, jaundice, and liver and gastrointestinal distress. 2,3 Copper nanoparticles (Cu NPs), one of the manufactured NPs, are now industrially produced and available commercially. Recently, Cu NP has shown great promise as an antibacterial material [4][5][6][7] and even been used as intrauterine contraceptive device (IUD).…”

Section: Introductionmentioning

confidence: 99%

Copper nanoparticle-induced ovarian injury, follicular atresia, apoptosis, and gene expression alterations in female rats

Yang¹,

Hu²,

Rao³

et al. 2017

IJN

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Numerous studies have reported the accumulation of copper nanoparticles (Cu NPs) in organs and the corresponding damage, although whether Cu NPs can be translocated to the ovaries and their ovarian toxicity are still unknown. In this study, three groups of female rats were injected with 3.12, 6.25, or 12.5 mg/kg Cu NPs for 14 consecutive days. The pathological changes, hormone levels, apoptosis and apoptotic proteins, oxidative stress, and gene expression characteristics in the ovaries were then investigated. The results demonstrated that the Cu NPs exhibited obvious accumulation in the rat ovaries, leading to ovarian injury, an imbalance of sex hormones, and ovarian cell apoptosis. Cu NP exposure activated caspase 3, caspase 8, caspase 9, and tBid, decreased the protein levels of Bcl-2, increased the expression levels of the proteins Bax and cytochrome c , and promoted malondialdehyde (MDA) accumulation and superoxide dismutase (SOD) reduction. Furthermore, gene microarray analysis showed that Cu NPs (12.5 mg/kg/d) caused 321 differentially expressed genes. Of these, 180 and 141 genes were upregulated and downregulated, respectively. Hsd17b1 , Hsd3b1 , Hsd3b6 , and Hsd3b were involved in steroid and hormone metabolism, whereas Mt3 and Cebpb were associated with apoptosis. Overall, these findings provide strong evidence that Cu NPs trigger both intrinsic and extrinsic apoptotic pathways and regulate key ovarian genes in oxidative stress-mediated ovarian dysfunction.

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Epidemiological investigation on chronic copper toxicity to children exposed via the public drinking water supply

Cited by 186 publications

References 23 publications

Leaching Assessments of Hazardous Materials in Cellular Telephones

Leaching Assessments of Hazardous Materials in Cellular Telephones

Detection of heavy metals (Cu+2, Hg+2) by biosynthesized silver nanoparticles

Copper nanoparticle-induced ovarian injury, follicular atresia, apoptosis, and gene expression alterations in female rats

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