Epidemiological profile and clinical characteristics of oral potentially malignant disorders and oral squamous cell carcinoma: A pilot study in Bidar and Gulbarga Districts, Karnataka, India

Kumar, G Kiran; Abidullah, Mohammed; Elbadawi, Lena; Dakhil, Siraj; Mawardi, Hani

doi:10.4103/jomfp.jomfp_116_18

Cited by 24 publications

(1 citation statement)

References 16 publications

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“…For the past few decades, the mortality rate of OSCC is relatively high with a five-year survival rate of 50% in spite of advancements in diagnosis and treatment modalities [3]. Thus, early diagnosis and appropriate treatment of OPMDs may facilitate the prevention of their malignant transformation into OSCCs [4].…”

Section: Introductionmentioning

confidence: 99%

A Comparison of Podoplanin Expression in Oral Leukoplakia and Oral Squamous Cell Carcinoma: An Immunohistochemical Study

Srinivasan¹,

Shyam²,

Kumar³

et al. 2023

Cureus

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Introduction: Oral squamous cell carcinoma (OSCC) accounts for about 90% to 95% of all malignancies of the oral cavity.The majority of OSCCs are preceded by oral potentially malignant disorders (OPMDs). Podoplanin (PDPN) is a mucin-like small transmembrane glycoprotein. Alterations in PDPN immunoexpression have been reported in OPMDs and OSCCs. Objective: The objectives of this study were to evaluate the role of PDPN immunoexpression in oral leukoplakia (OL) and different histological grades of OSCC and to assess the role of PDPN as a potential biomarker for predicting the risk of malignant transformation. Materials and methodology: Immunohistochemical analysis for PDPN was performed in 45 histologically confirmed cases of formalin-fixed, paraffin-embedded specimens of different grades of OSCCs and 15 cases of OLs with 15 cases of the normal oral mucosa (NOM) as controls. The expression and distribution of this marker were analyzed in these lesions. Results: The immunoexpression of PDPN showed a significant increase in the expression of the percentage of positive cells, staining intensity, location of staining in the epithelium, tumor islands, and within the cells, as well as the mean lymphatic micro vessel density between NOMs, OLs, and different grades of OSCCs. Conclusion: Upregulation of PDPN can be related to the malignant transformation of OLs and biological aggressiveness of OSCCs. The enhanced immunoexpression of PDPN signifies that this immunomarker can have a role in tumor cell differentiation and the neoplastic progression of OSCCs. Increased density of lymphatic vessels suggested an important role of lymphangiogenesis in tumor progression and also as a prognostic factor for lymph nodal metastasis.

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Section: Introductionmentioning

confidence: 99%

A Comparison of Podoplanin Expression in Oral Leukoplakia and Oral Squamous Cell Carcinoma: An Immunohistochemical Study

Srinivasan¹,

Shyam²,

Kumar³

et al. 2023

Cureus

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A standalone approach to utilize telomere length measurement as a surveillance tool in oral leukoplakia

et al. 2022

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Oral squamous cell carcinoma (OSCC) is often preceded by a white patch on a surface of the mouth, called oral leukoplakia (OL). As accelerated telomere length (TL) shortening in dividing epithelial cells may lead to oncogenic transformation, telomere length measurement could serve as a predictive biomarker in OL. However, due to high variability and lack of a universal reference, there has been a limited translational application. Here, we describe an approach of evaluating TL using paired peripheral blood mononuclear cells (PBMC) as an internal reference and demonstrate its translational relevance. Oral brush biopsy and paired venous blood were collected from 50 male OL patients and 44 male healthy controls (HC). Relative TL was measured by quantitative PCR. TL of each OL or healthy sample was normalized to the paired PBMC sample (TL ratio). In OL patients, the mean TL ratio was significantly smaller not only in the patch but also in distal normal oral tissue, relative to healthy controls without a high‐risk oral habit. Dysplasia was frequently associated with a subgroup that showed a normal TL ratio at the patch but significantly smaller TL ratio at a paired normal distal site. Our data suggest that evaluation of TL attrition using a paired PBMC sample eliminates the requirement of external reference DNA, makes data universally comparable and provides a useful marker to define high‐risk OL groups for follow‐up programs. Larger studies will further validate the approach and its broader application in other premalignant conditions.

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Therapeutic Targeting Tongue Squamous Cell Carcinoma via ICAM1 Antibody‐Drug Conjugates in Preclinical Models

Ma,

Xu,

Yang

et al. 2024

Advanced Therapeutics

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To date, the treatment options for metastatic and recurrent tongue squamous cell carcinoma (TSCC) remain limited due to the lack of effective drug targets and therapeutics. Here the identification of ICAM1 is reported as a TSCC target candidate for the development of antibody‐drug conjugate (ADC), an emerging class of targeted therapeutics. An unbiased and quantitative screening of a panel of 69 TSCC cell surface antigens is first performed that identifies ICAM1 as the most abundant hit. The overexpression level of ICAM1 is validated in 26 TSCC clinical specimens and four cell lines along with genomic information of 127 TSCC patients from the TCGA database. Based on this new target, the anti‐TSCC efficacy of ICAM1‐targeted ADCs featuring two payloads is evaluated of different mechanisms of action: MMAE and DXd. Both ADCs selectively and potently ablate TSCC tumors in the established SAS cell line and patient‐derived xenograft (PDX) models. The findings strongly support ICAM1 as a promising ADC target candidate for TSCC therapy.

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Epidemiological profile and clinical characteristics of oral potentially malignant disorders and oral squamous cell carcinoma: A pilot study in Bidar and Gulbarga Districts, Karnataka, India

Cited by 24 publications

References 16 publications

A Comparison of Podoplanin Expression in Oral Leukoplakia and Oral Squamous Cell Carcinoma: An Immunohistochemical Study

A Comparison of Podoplanin Expression in Oral Leukoplakia and Oral Squamous Cell Carcinoma: An Immunohistochemical Study

A standalone approach to utilize telomere length measurement as a surveillance tool in oral leukoplakia

Therapeutic Targeting Tongue Squamous Cell Carcinoma via ICAM1 Antibody‐Drug Conjugates in Preclinical Models

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