Epidemiological profile of Dupuytren’s disease in Taiwan (Ethnic Chinese): a nationwide population-based study

Yeh, Chin-Choon; Huang, Kuo‐Feng; Ho, Chung‐Han; Chen, Kuan-Ting; Liu, Cheng; Wang, Jhi‐Joung; Chu, Chin-Chen

doi:10.1186/s12891-015-0476-7

Cited by 19 publications

(12 citation statements)

References 44 publications

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“…In Asia, Egawa and colleagues 5 reported that the prevalence of DD in Japan was 19%, and recently Taiwan researchers reported a prevalence of 4.52 per 100,000 population. 7 McFarlane 14 pointed out that the unusually high prevalence of DD in Japan reported by Egawa et al 5 might be related to their accurate diagnosis of minimal disease. Their patients were actually elderly residents of nursing homes and few had enough contracture to warrant surgery.…”

Section: Discussionmentioning

confidence: 96%

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The Epidemiology of Dupuytren's Disease in Korea: a Nationwide Population-based Study

et al. 2018

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BackgroundTo date, there have been few reports on the nationwide population-based epidemiology of Dupuytren's disease (DD). We investigated the prevalence and incidence of DD in Korea using the large dataset provided by the Korean Health Insurance Review and Assessment Service. This study is the second nationwide epidemiological study of DD after the study in Taiwan.MethodsRecords of patients diagnosed with DD between 2007 and 2014 were extracted from the large dataset by diagnostic code searching (International Classification of Disease 10th revision code M72.0) and were included in the study. We calculated the prevalence and incidence of DD based on the total population of Korea provided by the Korean Statistical Information Service. Diseases associated with DD and the trends in surgery for DD were also analyzed.ResultsA total 16,630 patients were diagnosed with DD during the study period. The mean annual prevalence was 32.2 per 100,000 population (41.8 per 100,000 for men; 22.5 per 100,000 for women). The mean annual incidence was 1.09 per 100,000 population (1.80 per 100,000 for men; 0.38 per 100,000 for women). The common diseases associated with DD were hypertension (30.5%), diabetes mellitus (26.7%), hyperlipidemia (20.4%), ischemic heart disease (7.9%), and cerebrovascular disease (4.6%). The mean annual proportion of the patients who had surgery for DD was 5.24% of all DD patients.ConclusionThe prevalence and incidence of DD in Korea were 100–1,000 times lower than those in western countries; however, it was slightly larger than that in Taiwan.

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Section: Discussionmentioning

confidence: 96%

“… 4 However, the epidemiology of DD in Asia has been reported only in Japan in the past decades, 5 6 and recently in Taiwan. 7 Because of this relatively small number of Asian studies, the prevalence of DD in Caucasians appears more prominent.…”

Section: Introductionmentioning

confidence: 99%

The Epidemiology of Dupuytren's Disease in Korea: a Nationwide Population-based Study

et al. 2018

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“…In our survey, the ethnic distribution among Taiwanese was not considered in the RFTP development. The prevalence and transmission patterns of diseases were identified to be associated with variation in the migratory history, community distribution, or socioeconomic status of the major ethnic groups in Taiwan [ 28 – 31 ]. However, it was unclear if the ethnic composition among Taiwanese would be a factor influencing a local RFTP, as to our best knowledge a significant variation among ethnic groups in Taiwan was not yet confirmed in the face width and face length, the most critical facial dimensions underlying the RFTPs.…”

Section: Discussionmentioning

confidence: 99%

Characterization of small-to-medium head-and-face dimensions for developing respirator fit test panels and evaluating fit of filtering facepiece respirators with different faceseal design

Lin

Chen

2017

PLoS ONE

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A respirator fit test panel (RFTP) with facial size distribution representative of intended users is essential to the evaluation of respirator fit for new models of respirators. In this study an anthropometric survey was conducted among youths representing respirator users in mid-Taiwan to characterize head-and-face dimensions key to RFTPs for application to small-to-medium facial features. The participants were fit-tested for three N95 masks of different facepiece design and the results compared to facial size distribution specified in the RFTPs of bivariate and principal component analysis design developed in this study to realize the influence of facial characteristics to respirator fit in relation to facepiece design. Nineteen dimensions were measured for 206 participants. In fit testing the qualitative fit test (QLFT) procedures prescribed by the U.S. Occupational Safety and Health Administration were adopted. As the results show, the bizygomatic breadth of the male and female participants were 90.1 and 90.8% of their counterparts reported for the U.S. youths (P < 0.001), respectively. Compared to the bivariate distribution, the PCA design better accommodated variation in facial contours among different respirator user groups or populations, with the RFTPs reported in this study and from literature consistently covering over 92% of the participants. Overall, the facial fit of filtering facepieces increased with increasing facial dimensions. The total percentages of the tests wherein the final maneuver being completed was “Moving head up-and-down”, “Talking” or “Bending over” in bivariate and PCA RFTPs were 13.3–61.9% and 22.9–52.8%, respectively. The respirators with a three-panel flat fold structured in the facepiece provided greater fit, particularly when the users moved heads. When the facial size distribution in a bivariate RFTP did not sufficiently represent petite facial size, the fit testing was inclined to overestimate the general fit, thus for small-to-medium facial dimensions a distinct RFTP should be considered.

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“…Three examples of diseases with contrasting risk between populations, primarily for middle-age-onset, are Dupuytren's disease (DD), rheumatoid arthritis (RA), and lupus erythematosus (LE). DD heritability was determined by Larsen et al [72] as 80%, with extremely varied prevalence, affecting at older ages 22-32% of men in populations originating from Northern European countries [57], and significantly lower prevalence in populations from other origins, with the lowest prevalence in Korea [73], Taiwan and China [74] at 100-1000 times lower prevalence than in Northern European populations. According to Molokhia and McKeigue [75], West Africans have a higher risk of LE than Europeans, and Native Americans have a higher RA risk than Europeans.…”

Section: Estimates Of Population Genomic Parameters For Diseases Knowmentioning

confidence: 99%

Future Preventive Gene Therapy of Polygenic Diseases from a Population Genetics Perspective

Oliynyk

2019

Preprint

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With the accumulation of scientific knowledge of the genetic causes of common diseases and continuous advancement of gene-editing technologies, gene therapies to prevent polygenic diseases may soon become possible. This study endeavored to assess population genetics consequences of such therapies. Computer simulations were used to evaluate the heterogeneity in causal alleles for polygenic diseases that could exist among geographically distinct populations. The results show that although heterogeneity would not be easily detectable by epidemiological studies following population admixture, even significant heterogeneity would not impede the outcomes of preventive gene therapies. Preventive gene therapies designed to correct causal alleles to a naturally-occurring neutral state of nucleotides would lower the prevalence of polygenic early-to middle-age-onset diseases in proportion to the decreased population relative risk attributable to the edited alleles. The outcome would manifest differently for late-onset diseases, for which the therapies would result in a delayed disease onset and decreased lifetime risk, however the lifetime risk would increase again with prolonging population life expectancy, which is a likely consequence of such therapies. If gene therapies that prevent heritable diseases were to be applied on a large scale, the decreasing frequency of risk alleles in populations would reduce the disease risk or delay the age of onset, even with a fraction of the population receiving such therapies. With ongoing population admixture, all groups would benefit over generations.

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Epidemiological profile of Dupuytren’s disease in Taiwan (Ethnic Chinese): a nationwide population-based study

Cited by 19 publications

References 44 publications

The Epidemiology of Dupuytren's Disease in Korea: a Nationwide Population-based Study

The Epidemiology of Dupuytren's Disease in Korea: a Nationwide Population-based Study

Characterization of small-to-medium head-and-face dimensions for developing respirator fit test panels and evaluating fit of filtering facepiece respirators with different faceseal design

Future Preventive Gene Therapy of Polygenic Diseases from a Population Genetics Perspective

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