Epidemiological serosurvey and molecular characterization of sexually transmitted infections among 1890 sheltered homeless people in Marseille: Cross-sectional one day-surveys (2000–2015)

Ly, Tran Duc Anh; Hoang, Van Thuan; Louni, Meriem; Dao, Thi Loi; Badiaga, Sékéné; Tissot‐Dupont, Hervé; Brouqui, Philippe; Colson, Philippe; Gautret, Philippe

doi:10.1016/j.jinf.2020.11.026

Cited by 4 publications

(3 citation statements)

References 22 publications

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“…Seroprevalence surveys, although of varying size and quality, report higher HBV seroprevalence among PEH compared to the housed population ( Ly et al, 2021a ). Homelessness may be a risk factor for HBV infection or vice versa, while there are also shared risk factors which include associations with place of birth, older age, sexual partners with a history of hepatitis, and injecting drug or alcohol use ( Ly et al, 2021a , Ly et al, 2021b ; Figure 1C ). Low HBV vaccination uptake among PEH may relate to either never being offered the vaccine, or being unable to access follow-up doses ( Ly et al, 2021b , Taylor et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

The forgotten people: Hepatitis B virus (HBV) infection as a priority for the inclusion health agenda

Martyn

Eisen

Longley

et al. 2023

eLife

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Hepatitis B virus (HBV) infection represents a significant global health threat, accounting for 300 million chronic infections and up to 1 million deaths each year. HBV disproportionately affects people who are under-served by health systems due to social exclusion, and can further amplify inequities through its impact on physical and mental health, relationship with stigma and discrimination, and economic costs. The ‘inclusion health’ agenda focuses on excluded and vulnerable populations, who often experience barriers to accessing healthcare, and are under-represented by research, resources, interventions, advocacy, and policy. In this article, we assimilate evidence to establish HBV on the inclusion health agenda, and consider how this view can inform provision of better approaches to diagnosis, treatment, and prevention. We suggest approaches to redress the unmet need for HBV interventions among excluded populations as an imperative to progress the global goal for the elimination of viral hepatitis as a public health threat.

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Section: Introductionmentioning

confidence: 99%

The forgotten people: Hepatitis B virus (HBV) infection as a priority for the inclusion health agenda

Martyn

Eisen

Longley

et al. 2023

eLife

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“…The limited data available, however, suggest that cannabis consumption may be associated with alterations to mucosal microbial profiles [ 19 ]; the development of a diverse non- Lactobacillus -predominant vaginal microbiota [ 20 ]; an altered oral microbiome with an enhanced Streptococcus and Actinomyces and depressed Neisseria content [ 21 ]; risk of sexually transmitted disease in men [ 22 ]; seropositivity for hepatitis C virus [ 23 ]; and increased risk of fungal infections [ 24 ]. Moreover, Johnson et al have recently reported that environmental exposure to cannabis smoke in children increases the likelihood of viral respiratory diseases [ 25 ].…”

Section: The Antimicrobial Properties Of Cannabis and Cannabis-derive...mentioning

confidence: 99%

The Antimicrobial Properties of Cannabis and Cannabis-Derived Compounds and Relevance to CB2-Targeted Neurodegenerative Therapeutics

et al. 2022

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Cannabinoid receptor 2 (CB2) is of interest as a much-needed target for the treatment or prevention of several neurogenerative diseases. However, CB2 agonists, particularly phytocannabinoids, have been ascribed antimicrobial properties and are associated with the induction of microbiome compositional fluxes. When developing novel CB2 therapeutics, CB2 engagement and antimicrobial functions should both be considered. This review summarizes those cannabinoids and cannabis-informed molecules and preparations (CIMPs) that show promise as microbicidal agents, with a particular focus on the most recent developments. CIMP–microbe interactions and anti-microbial mechanisms are discussed, while the major knowledge gaps and barriers to translation are presented. Further research into CIMPs may proffer novel direct or adjunctive strategies to augment the currently available antimicrobial armory. The clinical promise of CIMPs as antimicrobials, however, remains unrealized. Nevertheless, the microbicidal effects ascribed to several CB2 receptor-agonists should be considered when designing therapeutic approaches for neurocognitive and other disorders, particularly in cases where such regimens are to be long-term. To this end, the potential development of CB2 agonists lacking antimicrobial properties is also discussed.

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“…Classical methods for HBsAg detection include enzyme-linked immunosorbent assay (ELISA), , electrochemiluminescence immunoassay (ECLIA), , chemiluminescence microparticle immunoassay (CMIA), , etc. However, these methods still have some technical disadvantages, such as cumbersome operation, long testing times, and high cost.…”

mentioning

confidence: 99%

Systematic Optimization of Universal Real-Time Hypersensitive Fast Detection Method for HBsAg in Serum Based on SERS

Xu,

Wu,

et al. 2024

Anal. Chem.

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Hepatitis B virus (HBV) is a major cause of liver cirrhosis and hepatocellular carcinoma, with HBV surface antigen (HBsAg) being a crucial marker in the clinical detection of HBV. Due to the significant harm and ease of transmission associated with HBV, HBsAg testing has become an essential part of preoperative assessments, particularly for emergency surgeries where healthcare professionals face exposure risks. Therefore, a timely and accurate detection method for HBsAg is urgently needed. In this study, a surface-enhanced Raman scattering (SERS) sensor with a sandwich structure was developed for HBsAg detection. Leveraging the ultrasensitive and rapid detection capabilities of SERS, this sensor enables quick detection results, significantly reducing waiting times. By systematically optimizing critical factors in the detection process, such as the composition and concentration of the incubation solution as well as the modification conditions and amount of probe particles, the sensitivity of the SERS immune assay system was improved. Ultimately, the sensor achieved a sensitivity of 0.00576 IU/mL within 12 min, surpassing the clinical requirement of 0.05 IU/mL by an order of magnitude. In clinical serum assay validation, the issue of false positives was effectively addressed by adding a blocker. The final sensor demonstrated 100% specificity and sensitivity at the threshold of 0.05 IU/mL. Therefore, this study not only designed an ultrasensitive SERS sensor for detecting HBsAg in actual clinical serum samples but also provided theoretical support for similar systems, filling the knowledge gap in existing literature.

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Epidemiological serosurvey and molecular characterization of sexually transmitted infections among 1890 sheltered homeless people in Marseille: Cross-sectional one day-surveys (2000–2015)

Cited by 4 publications

References 22 publications

The forgotten people: Hepatitis B virus (HBV) infection as a priority for the inclusion health agenda

The forgotten people: Hepatitis B virus (HBV) infection as a priority for the inclusion health agenda

The Antimicrobial Properties of Cannabis and Cannabis-Derived Compounds and Relevance to CB2-Targeted Neurodegenerative Therapeutics

Systematic Optimization of Universal Real-Time Hypersensitive Fast Detection Method for HBsAg in Serum Based on SERS

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