Epidemiological studies on <i>Salmonella senftenberg</i>: I. Relations between animal foodstuff, animal and human isolations

Hobbs, Betty C.; Hugh‐Jones, Martin

doi:10.1017/s0022172400041450

Cited by 15 publications

(11 citation statements)

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“…The disease histories and details of animal feeding on these farms are given in a previous paper (Hobbs & Hugh-Jones, 1969) and the possibility of a feed contamination discussed. In the farms from which S. senftenberg had been isolated, no disease was reported from a dairy herd, there was a chronic diarrhoea of unknown cause in a ewe flock, and Gumboro disease, starvation syndrome and omphalitis in each of three poultry flocks.…”

Section: Farm Investigations Farms B-hmentioning

confidence: 99%

“…The roof of the feed stores appeared to be sound. The poults receive company IV 'turkey starter' (Hobbs & Hugh-Jones, 1969) for the first 5 weeks in self-feeders which are supposed to be checked and the faeces removed every day. At 5 weeks old the birds are moved into growing or fattening sheds, and fed on a growing ration of company V white fish meal and grain (soya, maize, barley or oats, vitamin and minerals).…”

Section: Farm Amentioning

confidence: 99%

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Epidemiological studies onSalmonella senftenberg: II. Infections in farm animals

Hugh‐Jones¹

1969

J. Hyg.

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SUMMARYBetween August 1964 and November 1965Salmonella senftenbergwas isolated from poultry, sheep and cattle on eight farms in England and Scotland. From an analysis of the case records its presence would appear to be incidental; but it may contribute to poultry mortality by acting in conjunction with other intercurrent infections or following stressful events such as severe debeaking or cold brooder conditions.I should like to thank the officers of the veterinary field investigation and research services who made available their records and notes for this work, and who visited the farms and hatcheries, but especially Mr R. Duff, Veterinary Laboratory, Lasswade, for his reports on the turkey poults from farm A; also Dr Betty Hobbs and Mr B. Hanson for their valuable criticisms.

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Section: Farm Investigations Farms B-hmentioning

confidence: 99%

Section: Farm Amentioning

confidence: 99%

Epidemiological studies onSalmonella senftenberg: II. Infections in farm animals

Hugh‐Jones¹

1969

J. Hyg.

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“…Few outbreaks of Salmonella Senftenberg infection have occurred in England and Wales, those documented being associated with infant formula (Sanford et al, 1969;Rushdy et al, 1998). The organism has also been isolated in England and Wales from coconut products (Rushdy et al, 1998), animal feed (Hobbs and Hugh-Jones, 1969;, and livestock (Liebana et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

Packed withSalmonella—Investigation of an International Outbreak ofSalmonellaSenftenberg Infection Linked to Contamination of Prepacked Basil in 2007

Pezzoli

Elson²,

Little³

et al. 2008

Foodborne Pathogens and Disease

111

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Salmonella Senftenberg is uncommon in the United Kingdom. In January-June 2007, the Health Protection Agency reported on 55 primary human cases of Salmonella Senftenberg in England and Wales. In May 2007, fresh basil sold in the United Kingdom was found to be contaminated with Salmonella Senftenberg. We launched an investigation to elucidate the cause of this outbreak. Isolates were examined using plasmid profiling and pulsed-field gel electrophoresis, and the outbreak strain (SSFTXB.0014) was identified. We enquired via Enter-net whether other countries had isolated the outbreak strain, analyzed samples of fresh herbs from U.K. retailers, and interviewed patients on food history. Thirty-two patient-cases were referred to this outbreak in England and Wales. Onsets of illness occurred between 5 March and 6 June 2007. Fifty-six percent of patient-cases were females and 90% adults (>20 years old); three were admitted to hospital as a result of Salmonella infection. Scotland, Denmark, the Netherlands, and the United States reported on 19 cases of Salmonella Senftenberg infection presenting with the outbreak strain since January 2007. Eight samples of prepacked fresh basil imported from Israel tested positive with the same strain. A minority of patients could recall the consumption of basil before illness, and some reported consumption of products where basil was a likely ingredient. Environmental investigations in Israel did not identify the contamination source. Microbiological evidence suggested an association between contamination of fresh basil and the cases of Salmonella Senftenberg infection, leading to withdrawal of basil from all potentially affected batches from the U.K. market.

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“…S. Senftenberg was reported as causing several foodborne outbreaks of gastroenteritis and invasive intestinal infections in humans (2)(3)(4). A previously reported nosocomial outbreak of S. Senftenberg in humans was directly related to contaminated turkey supplied to the hospital kitchen, which in turn contaminated the hospital equipment (2,5). Various S. Senftenberg serotypes are frequently isolated from feed mills and poultry houses (6)(7)(8).…”

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confidence: 99%

Characterization and Evaluation of a Salmonella enterica Serotype Senftenberg Mutant Created by Deletion of Virulence-Related Genes for Use as a Live Attenuated Vaccine

Kamble

Lee

2016

Clin Vaccine Immunol

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Natural infections of chickens with Salmonella enterica subsp. enterica serovar Senftenberg (S. Senftenberg) are characterized by low-level intestinal invasiveness and insignificant production of antibodies. In this study, we investigated the potential effects of lon and cpxR gene deletions on the invasiveness of S. Senftenberg into the intestinal epithelium of chickens and its ability to induce an immune response, conferring protection against S. Senftenberg infection. With the allelic exchange method, we developed JOL1596 (⌬lon), JOL1571 (⌬cpxR), and JOL1587 (⌬lon ⌬cpxR) deletion mutants from wild-type S. Senftenberg. Deletion of the lon gene from S. Senftenberg produced increased frequency of elongated cells, with significantly greater amounts of exopolysaccharide (EPS) than in the cpxR-deleted strain and the wild-type strain. The in vivo intestinal loop invasion assay showed a significant increase in epithelial invasiveness for JOL1596 (⌬lon) and JOL1587 (⌬lon ⌬cpxR), compared to JOL1571 (⌬cpxR) and the wild-type strain. Furthermore, the S. Senftenberg wild-type and mutant strains were internalized at high levels inside activated abdominal macrophages from chicken. The in vivo inoculation of JOL1587 (⌬lon ⌬cpxR) into chickens led to colonization of the liver, spleen, and cecum for a short time. Chickens inoculated with JOL1587 (⌬lon ⌬cpxR) showed significant increases in humoral, mucosal, and cellular immune responses specific to S. Senftenberg antigens. Postchallenge, compared to the control group, the JOL1587 (⌬lon ⌬cpxR)-inoculated chickens showed not only lower persistence but also faster clearance of wild-type S. Senftenberg from the cecum. We conclude that the increased intestinal invasiveness and colonization of internal organs exhibited by JOL1587 (⌬lon ⌬cpxR) led to the establishment of immunogenicity and conferred protective efficacy against S. Senftenberg infections in chickens.S almonella enterica subsp. enterica serovar Senftenberg (S. Senftenberg) is a nontyphoidal serovar (NTS) of the Gram-negative facultative intracellular pathogen S. enterica (1). S. Senftenberg was reported as causing several foodborne outbreaks of gastroenteritis and invasive intestinal infections in humans (2-4). A previously reported nosocomial outbreak of S. Senftenberg in humans was directly related to contaminated turkey supplied to the hospital kitchen, which in turn contaminated the hospital equipment (2, 5). Various S. Senftenberg serotypes are frequently isolated from feed mills and poultry houses (6-8). The trademark of S. Senftenberg infections in chicken is heterogeneity regarding persistence in the cecum and fecal shedding (9). Also, S. Senftenberg has been shown to resist stresses such as low pH, heating, desiccation, irradiation, and cleaning and disinfection procedures used on poultry farms (1, 10, 11). To date, there have been no reported vaccine candidates for control of S. Senftenberg in poultry, and the potential risk of transmission of S. Senftenberg from chickens to human populations emphasizes the ne...

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Epidemiological studies on Salmonella senftenberg: I. Relations between animal foodstuff, animal and human isolations

Cited by 15 publications

References 3 publications

Epidemiological studies onSalmonella senftenberg: II. Infections in farm animals

Epidemiological studies onSalmonella senftenberg: II. Infections in farm animals

Packed withSalmonella—Investigation of an International Outbreak ofSalmonellaSenftenberg Infection Linked to Contamination of Prepacked Basil in 2007

Characterization and Evaluation of a Salmonella enterica Serotype Senftenberg Mutant Created by Deletion of Virulence-Related Genes for Use as a Live Attenuated Vaccine

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