Epidemiological study of lower limb amputation in England between 2003 and 2008

Abstract

Major and minor amputation rates were stable across England between 2003 and 2008, accompanied by a significant reduction in perioperative mortality. There were significant geographical variations in amputation rates, mortality rates and the below-knee : above-knee amputation ratio.

Factors Affecting Post-Operative Mortality Rate after Major Lower Extremity Amputations in a Tertiary Institution in Singapore

“…1-7 A significantly higher mortality rate for AKA (18.4%) than BKA patients (4.5%) is also consistent with previous studies. 2 There are several significant findings in our study. Firstly, pre-operative septic shock, ASA 4 status and site of amputation of AKA are significant predictors of higher post-operative in hospital mortality rate and ICU admission.…”

“…[1][2][3][4][5][6][7] Patient's pre-operative condition, including their ASA status, presence of septic shock and site of amputation undertaken are significant predictors of post-operative in hospital mortality rate and ICU admission rate. Patients with pre-operative septic shock, ASA 4 status and undergoing AKA should be regarding as high risk group, and appropriate level of intra-operative monitoring and post-operative disposition should be arranged.…”

“…[1][2][3][4][5][6][7] With the increasing incidence of diabetes mellitus in Asia, the incidence of MLEA surgeries is set to increase over the next few years [8][9][10] as diabetes is one of the major risk factors for critical limb ischaemia and lower limb amputation surgeries. 10 It is important to identify factors that affects outcome in this group of patients.…”

“…Studies have found the 30-day mortality rate for this group of patients to be ranging from 7-23%. [1][2][3][4][5][6][7] Patients undergoing these operations often have significant multiple comorbidities 4 and pre-operative hemodynamic disturbances, putting them at high risk both for surgery and for the further hemodynamic changes associated with anaesthesia. Most studies evaluating factors associated with peri-operative mortality rates in this group of patients are conducted in Caucasian populations, [3][4][5][6] and we find a lack of similar studies evaluating these factors in the Asian population.…”

Advances in the Treatment of Peripheral Vascular Disease in Diabetes and Reduction of Major Amputations

“…11 In another study, major and minor amputation rates were stable across England between 2003 and 2008, accompanied by a significant reduction in perioperative mortality. 12 Other authors have reported that there was significant reduction in the incidence of major LEA in patients with diabetes over a 7-year period (January 1, 2000 to December 31, 2006). 13 Differences in outcomes have been recorded between patients with PAD versus patients with diabetes and PAD.…”