Epidemiological study of Moyamoya disease in Taiwan

Hung, Chao-Ching; Tu, Yong Kwang; Su, Chin Cheng; Lin, Lieh Sheng; Shih, Cheng‐Ping

doi:10.1016/s0303-8467(97)00036-x

Cited by 52 publications

(38 citation statements)

References 3 publications

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“…The overall women-to-men ratio in our analysis was similar to the observations of an earlier study in Taiwan (1.3) 14 and was much higher in patients hospitalized during 2006 to 2011 (1.7) than during 2000 to 2005 (1.1). Our analysis also revealed increased incidence in ≥10-year-old subjects in the later period, and the highest peak of age distribution increased in women.…”

Section: May 2014supporting

confidence: 90%

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Epidemiology of Moyamoya Disease in Taiwan

Chen

Yang

Chien

et al. 2014

Stroke

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Background and Purpose— Previous studies have shown regional and temporal variations in epidemiological features of moyamoya disease, but population-based studies in regions other than Japan are limited. We investigated the incidence and patients characteristics of moyamoya disease during 12 years in Taiwan using claims databases of a universal health insurance system. Methods— From the inpatient databases of the Taiwan National Health Insurance program, we identified subjects who had an initial hospitalization with moyamoya disease and had been underwent cerebral angiography as incidence cases during 2000 to 2011. The incidence and the patient characteristics were described by age and time periods of the hospitalization. Results— During the 12-year period, 422 patients were identified, representing an annual incidence of 0.15 per 100 000 person-years. Adults exhibited an upward trend in incidence with an incidence rate ratio of 1.74 (95% confidence interval [1.17–2.58]) in years 2010 to 2011 comparing with years 2000 to 2001. However, children had a decreased incidence except a slightly increase in the last 2 years. Compared with patients hospitalized during 2000 to 2005, patients identified during 2006 to 2011 had greater women-to-men ratio (1.7 versus 1.1, P =0.048). Children were more likely to have comorbid epilepsy than were adult patients (25.0% versus 3.4%, P =0.002). Hemorrhagic stroke was rare among pediatric patients but presented more frequently in adults. However, ischemic stroke was more prevalent in both groups. Conclusions— The incidence of moyamoya disease has increased in adults but not in children from 2000 to 2011 in Taiwan. Sex ratio and comorbid conditions differed by age and study period.

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Section: May 2014supporting

confidence: 90%

“…4,[6][7][8]12,[14][15][16][17] Explanations for the discrepancy may include the differences in survey methods and the studied regions, ethnic groups, and time periods. In general, studies from regions other than Asia yielded lower incidence.…”

Section: Discussionmentioning

confidence: 99%

Epidemiology of Moyamoya Disease in Taiwan

Chen

Yang

Chien

et al. 2014

Stroke

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“…A bimodal age distribution has been demonstrated in Asia, with children primarily suffering from ischemic symptoms and adults experiencing intracranial hemorrhage. 8,10,[25][26] This study also revealed a 2-peak pattern, the higher peak observed in patients age 5 to 9 years being more prominent than in adults. The result is similar to reports from Japan and South Korea.…”

Section: Discussionsupporting

confidence: 66%

“…Recently, an epidemiological study in the area of Nanjing, the capital city of Jiangsu province, with a total population of approximately 6.2 million, showed the prevalence at 3.92/100 000, 9 which was lower than the prevalence of 6.03/100 000 found in Japan 3 ; however, it was similar to the report from Taiwan. 8 This study was limited to a small area of China and there was no clinical data on treatment and outcomes for this area. Reviewing the literature, one realizes that the knowledge about clinical features, surgical treatment, and long-term outcome of MMD in mainland China is minimal.…”

Section: Discussionmentioning

confidence: 99%

“…2 During the past few decades, many studies have documented the epidemiological and clinical characteristics of the disease. [3][4][5][6][7][8] Some of these studies have indicated a high prevalence of MMD in Asian countries, particularly in Japan, South Korea, and China. The prevalence, clinical features, treatment, and long-term outcome of MMD in Japan and South Korea have been well-documented.…”

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confidence: 99%

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Moyamoya Disease in China

Duan

Bao

Yang

et al. 2012

Stroke

163

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Background and Purpose-Here we describe the clinical features and outcomes of patients with moyamoya disease who were surgically treated at a single institution in China. Methods-Our cohort included 802 patients with moyamoya disease. Demographic and clinical characteristics were obtained by retrospective chart review; follow-up information and outcome were obtained through clinical visits, telephone, or letter interview. We used the Kaplan-Meier methods to estimate stroke risk by treatment status. Results-The median age for the onset of symptoms was 28 (range, 0.5-77) years. Two definite peaks in age distribution were found. The ratio of women to men was 1:1 (398/404). Familial occurrence of moyamoya disease was 5.2%. The initial symptom was ischemia, hemorrhage, or others in 564, 113, and 125 patients, respectively. Twenty-nine of the 802 patients (3.6%) received conservative management. The remaining 773 patients (96.4%) underwent neurosurgical revascularization procedures, and 502 of these were bilateral. The median follow-up after surgery (nϭ773) or conservative management (nϭ26) was 26.3 months (range, 6.0 -101.9 months). Most subsequent ischemic events appeared in the first 2 years after surgery. The Kaplan-Meier estimated stroke risk was 10.1% in the first 2 years, and the 5-year-Kaplan-Meier risk of stroke was 12.7% after surgery for all patients treated with surgical revascularization. Conclusions-This study on the clinical features of moyamoya disease in mainland China indicated bimodal incidence distribution with women-to-men ratios of 1:1 and lower rate of hemorrhages in adults compared with in children. Patients had low rates of postoperative ischemic or hemorrhagic strokes, and the majority of patients had preserved functional status after revascularization. (Stroke. 2012;43:56-60.)

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Moyamoya Disease in North America

Guzman

Khan

2010

Moyamoya Disease Update

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Epidemiological study of Moyamoya disease in Taiwan

Cited by 52 publications

References 3 publications

Epidemiology of Moyamoya Disease in Taiwan

Epidemiology of Moyamoya Disease in Taiwan

Moyamoya Disease in China

Moyamoya Disease in North America

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