Epidemiological study of Neisseria meningitidis strains isolated from cases of meningococcal disease in Santa Catarina State, Brazil, 1987–2003

Bertoncini, Rita de Cássia C; Herberts, Ricardo André; Dário, Marcelo Goulart; Merlin, Carlos Roberto; Miletti, Luiz Cláudio

doi:10.1016/j.puhe.2007.03.017

Cited by 6 publications

(5 citation statements)

References 9 publications

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“…It was also reported that the incidence of IMD peaked in 1974 from SC, when the incidence increased to 26.1 per 100 000 inhabitants. In addition, between 1987 and 2003, the majority of cases (73.5 %) were due to serogroup B, 25.8 % due to serogroup C and 0.7 % due to other serogroups in SC [17]. Recently, another study conducted in Brazil reported an incidence rate of 0.57 cases per 100 000 inhabitants in PR, 0.41 cases per 100 000 in SC and 0.94 cases per 100 000 in RS [11].…”

Section: Discussionmentioning

confidence: 99%

Surveillance of invasive meningococcal disease in the south of Brazil: considerations of immunization programme

Silveira

Crespo

Conrad

et al. 2021

Journal of Medical Microbiology

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Invasive meningococcal disease (IMD) is a major cause of meningitis and septicaemia worldwide. The switches in serogroup predominance contribute to the unpredictable nature of the disease with significant health impacts. The aim of this study was to determine the epidemiological profile of IMD in Rio Grande do Sul, Santa Catarina and Paraná, three states in the south of Brazil. All meningitis cases confirmed by clinical and/or laboratory criteria notified to the national information system for notifiable diseases between 2015 and 2019 were analysed. Proportions of serogroup and incidence by age were calculated. A total of 17 894 cases of IMD were reported during this period. Of these, 9029 cases (50 %) were due to serogroup C. Furthermore, serogroup W was responsible for almost half of the cases among children younger than 5 years old during 2017 and 2018, with an overall incidence of 33.3 cases per 100 000 infants. Despite the reduction in serogroup C after the introduction of meningococcal C conjugate vaccine into a childhood immunization programme in Brazil, it remains a significant healthcare issue in the south of the country. Changes in disease epidemiology were observed and serogroup W was the most common among children below 5 years of age in 2017 and 2018. Although future cost-effectiveness studies are necessary, our results could have future implications for meningococcal vaccination programmes.

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Section: Discussionmentioning

confidence: 99%

Surveillance of invasive meningococcal disease in the south of Brazil: considerations of immunization programme

Silveira

Crespo

Conrad

et al. 2021

Journal of Medical Microbiology

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“…Epidemiological studies investigating carriage of N. meningitidis approximately 10 cases per 100 000 population in some parts of the country (particularly in Rio de Janeiro). However, there was another shift back to serogroup B towards the end of the decade which caused approximately 80% of cases 14,19,[48][49][50][51]. Serogroup C was dominant in Argentina from 1995 until the end of the decade 7,14,15,45.…”

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confidence: 99%

“…Serogroup C was dominant in Argentina from 1995 until the end of the decade 7,14,15,45. In the 2000s, serogroup B was the leading cause of disease although serogroup C increased from 2002 in Brazil and caused 63% of cases in Sao Paulo in 2005 4,19,48,50,52. From 2000 to 2006, two-thirds of isolates were from serogroup C in Ecuador 14.…”

mentioning

confidence: 99%

An epidemiological review of changes in meningococcal biology during the last 100 years

Abio

Neal

Beck

2013

Pathogens and Global Health

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“…The average annual incidence rate was 5.3 cases/100 000 inhabitants, with a peak of 8.1 in 1995 and a minimum of 1.2 in 1986 (Masuda et al, 2015). Bertoncini et al (2007) also showed a high incidence rate, with an average of 7.9 cases/100 000 inhabitants in Santa Catarina between 1987 and 2003.…”

Section: Incidencementioning

confidence: 95%

Epidemiological burden of meningococcal disease in Brazil: A systematic literature review and database analysis

Almeida¹,

Spinardi²,

Cané³

2019

International Journal of Infectious Diseases

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The aim of this study was to evaluate the epidemiological profile of invasive meningococcal disease (IMD) in Brazil, the first Latin American country to introduce the group C meningococcal conjugate vaccine (included in the vaccination schedule in 2010). Methods: A systematic review was conducted, covering the years 2005-2017, to identify epidemiological information on IMD and Neisseria meningitidis carriers in Brazil. Documents from the Brazilian Ministry of Health and two public databases were analyzed to determine annual incidence rates, absolute numbers of diagnosed cases, serogroups identified, the relative distribution of cases per serogroup, and the case fatality rate (CFR). Results: Sixteen studies were selected. The incidence rate ranged from 0.88 to 5.3 cases per 100 000 inhabitants per year. According to secondary data, the annual incidence of IMD in 2015 was highest in males <1 year old (7.1/100 000). The number of diagnosed cases declined significantly over the years. In the literature, IMD showed a CFR from 20.0% to 50.0%, and a higher CFR for serogroup W (17.8%). Secondary data showed an absolute reduction in meningitis-attributable deaths between 2007 and 2015; however, the CFR remained stable (11.1% in 2007 and 8.4% in 2015). In 2015, serogroup W showed the highest CFR (24.1%), followed by serogroups C (19.2%), B (17.7%), and Y (14.3%). Conclusions: Despite a reduction in cases, the CFR remained stable and similar in the different age groups, even for disease caused by different serogroups. The highest CFR was found to be associated with serogroup W.

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Epidemiological study of Neisseria meningitidis strains isolated from cases of meningococcal disease in Santa Catarina State, Brazil, 1987–2003

Cited by 6 publications

References 9 publications

Surveillance of invasive meningococcal disease in the south of Brazil: considerations of immunization programme

Surveillance of invasive meningococcal disease in the south of Brazil: considerations of immunization programme

An epidemiological review of changes in meningococcal biology during the last 100 years

Epidemiological burden of meningococcal disease in Brazil: A systematic literature review and database analysis

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