Epidemiological Study on the Effect of Pre-Hypertension and Family History of Hypertension on Cardiac Autonomic Function

Wu, Jin Shang; Lu, Feng Hwa; Yang, Yi Ching; Lin, Tzu-Wei; Chen, Jia Jin; Wu, Chih Hsing; Huang, Ying; Chang, Chih Jen

doi:10.1016/j.jacc.2007.12.053

Cited by 60 publications

(49 citation statements)

References 27 publications

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“…Similar results are obtained by Shenoy et al [5] However, Devrath et al [6] and Wu et al [7] have shown decreased parasympathetic activity in offsprings of hypertensive parents. Table No.…”

Section: Discussionsupporting

confidence: 88%

Study of autonomic functions in young adults of hypertensive and normotensive parents

Singla

Kharche

Joshi

2015

Int J of Biomed & Adv Res

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Background: Hypertension is a major public health problem worldwide, including India. Nowadays, prehypertension is common in young adults. It has genetic basis and runs in families. Parental history of hypertension increases the risk of developing hypertension, especially if both parents are hypertensive. Cause & effect relation of hypertension & autonomic dysfunction is not clear. Therefore, this study was planned to see autonomic function alterations in young adults of hypertensive parents, if any. Methodology: In this study autonomic activity was assessed in students with both parents hypertensive (n= 30), one parent hypertensive (n= 30) and both parents normotensive (n= 30). Resting heart rate and BP was measured for parasympathetic function assessment and rise in diastolic BP with hand grip dynamometer was used for sympathetic function assessment. Results: The study showed no significant difference in resting pulse rate of all the groups. BP was slightly higher in groups with hypertensive parents as compared to a group of normotensive parents, but the difference was statistically insignificant. Statistically significant rise in diastolic BP with handgrip dynamometer was observed in subjects with hypertensive parents. Conclusion: This rise in diastolic BP indicates increased sympathetic activity. Our results showed higher sympathetic activity in those with hypertensive parents. It also confirmed the genetic basis of sympathetic (vasomotor) tone. Young adults having hypertensive parents are at a greater risk of hypertension at an early age. Regular assessment of blood pressure and autonomic function with lifestyle modifications should be recommended to delay onset of hypertension in them.

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“…Similar results are obtained by Shenoy et al [5] However, Devrath et al [6] and Wu et al [7] have shown decreased parasympathetic activity in offsprings of hypertensive parents. Table No.…”

Section: Discussionsupporting

confidence: 88%

Study of autonomic functions in young adults of hypertensive and normotensive parents

Singla

Kharche

Joshi

2015

Int J of Biomed & Adv Res

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“…A significant reduction in HRV measurements was seen in all groups, from no risk factor normotensives to hypertensives (17). In the hypertensive patients in our study, no statistically significant effect of family risk factors were seen on the parameters of HRV.…”

Section: Resultscontrasting

confidence: 40%

“…According to an epidemiological study which included 1436 hypertensive, prehypertensive and normotensive patients and subjects, hypertensive and prehypertensive patients had decreased HRV measurements compared to normotensive individuals, and similarly hypertensives had lower measurements compared to prehypertensives (17). In our study, no significant difference was observed between patients previously treated for hypertension and those newly diagnosed hypertensives in terms of demographic, clinical and laboratory inability to obtain a sufficient number of patients and a lack of grouping by treatment drug seems to be important limitations of the current study.…”

Section: Türk Nefroloji Diyaliz Ve Transplantasyon Dergisi Turkish Nementioning

confidence: 99%

vCardiac Autonomic Neuropathy and Complications of Primary Hypertension: Is Autonomic Neuropathy a Cause or a Result?

Ay¹,

Bulucu²,

Karaman³

et al. 2016

Turk Neph Dial Transpl

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OBJECTIVE: Cardiac autonomic dysfunction (COD) is one of the important factors implicated in the pathogenesis of primary hypertension (HT). Heart rate variability (HRV) measurement has been used widely to determine the COD. We aimed to examine the HRV in primary hypertension and its relationships with end organ damage. MATERIAL and METHODS:Ninety adult patients and 28 healthy controls were included into the study. Heart rates (HRs) and HRV parameters were measured by monitoring with 24-hour Holter electrocardiographic records. Patients were assessed in terms of retinopathy, microalbuminuria and left ventricle hypertrophy. RESULTS:Primary hypertensive patients had significantly higher blood pressure (BP) values than those of the controls. Minimum HRs of all patients were significantly higher than controls, while HRV parameters showed significantly lower values in the patients compared to controls. The HRV parameters showed no significant correlations with retinopathy, left ventricle hypertrophy, microalbuminuria and cardiovascular risk factors. CONCLUSION:Lower HRV parameters in hypertensive patients probably suggests the presence of a COD. However, such a difference was not observed between the newly and previously diagnosed patients indicating that the HRV seems not to be influenced by antihypertensive treatment.

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“…The power component of this frequency part can be calculated as an absolute power by power spectral density (PSD) graphics, such as in Figure 1. The LF and HF power values can be given in a normalized form as a result of the proportion of each power component value and the value obtained by subtracting the power value belonging to the VLF band from the total power [14]. It has been verified by other studies that the power value of the HF component varies according to the parasympathetic effects completely [13][14][15].…”

Section: Signal Processingmentioning

confidence: 99%

Investigation of respiratory and heart rate variability in hypertensive patients

Aldemir¹,

Tokmakçı²

2015

Turk J Elec Eng & Comp Sci

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Abstract:In this paper, in order to examine the effect of respiration on heart rate variability (HRV), signal processing analyses were performed between the signal received from the periodic movement of the chest of respiration and the pulse plethysmograph (PPS) signal, providing the calculation of both the time and frequency behavior of HRV and also including pulse rate information at the same time. Respiration is used as the comparison parameter in both healthy subjects and in hypertensive patients, not only with the time and frequency components of the HRV, but also with the galvanic skin resistance simultaneously taken with body temperature and by calculating these signal changes. In our study, we aim to not only investigate the relationship between hypertension and HRV, but also to investigate the effect of respiration. Hence, in this study, 19 hypertensive patients and 19 healthy controls, who are all women, are used as subjects. As a result of the data received and analyzed from the subjects, HRV both in hypertensive and healthy subjects, the mean value of the high-frequency component and respiratory signal (RSP), and the mean value of the lowfrequency/high-frequency ratio accepted as a sympathovagal balance index of the heart rate and RSP are statistically associated.

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Epidemiological Study on the Effect of Pre-Hypertension and Family History of Hypertension on Cardiac Autonomic Function

Abstract: Our study provides evidence that CAF plays a role in pre-hypertension and that altered autonomic function is already present in subjects with FHH. An autonomic imbalance shifting with augmented sympathetic tone was more enhanced in pre-hypertension.

Cited by 60 publications

References 27 publications

Study of autonomic functions in young adults of hypertensive and normotensive parents

Study of autonomic functions in young adults of hypertensive and normotensive parents

vCardiac Autonomic Neuropathy and Complications of Primary Hypertension: Is Autonomic Neuropathy a Cause or a Result?

Investigation of respiratory and heart rate variability in hypertensive patients

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