Epidemiological surveillance and wild-type MIC distribution of Legionella pneumophila in north-western Spain. 2003–2016

March, Gabriel A.; Gutiérrez, María P.; López, Irene; Muñoz, Mauricio Pastor; Lejarazu, Raúl Ortíz de; Simarro, Marı́a; Orduña, Antonio; Bratos, Miguel Ángel

doi:10.1016/j.eimce.2018.11.009

Cited by 1 publication

(1 citation statement)

References 22 publications

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“…However, even in studies where the CLSI or EUCAST criteria were applied, the determination of antibiotic susceptibility was not defined ( Table S1 raw data; [ 12 , 67 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 ]. In most articles, the authors preferred to comment on the activity of the tested antibiotics against the studied isolates rather than define the susceptibility against them ( Table S1 raw data; [ 96 , 100 ]. The lack of a clear characterization of the L. pneumophila isolates as resistant or susceptible in the proposed CLSI and EUCAST protocols adds further confusion to the study of L. pneumophila microbial susceptibility.…”

Section: Resultsmentioning

confidence: 99%

Antibiotic Resistance of Legionella pneumophila in Clinical and Water Isolates—A Systematic Review

Παππά

Chochlakis

Sandalakis

et al. 2020

IJERPH

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The current systematic review investigates the antibiotic susceptibility pattern of Legionella pneumophila isolates from the 1980s to the present day, deriving data from clinical and/or water samples from studies carried out all over the world. Eighty-nine papers meeting the inclusion criteria, i.e., “Legionella pneumophila” and “resistance to antibiotics”, were evaluated according to pre-defined validity criteria. Sixty articles referred to clinical isolates, and 18 articles reported water-related L. pneumophila isolates, while 11 articles included both clinical and water isolates. Several methods have been proposed as suitable for the determination of MICs, such as the E-test, broth and agar dilution, and disk diffusion methods, in vivo and in vitro, using various media. The E-test method proposed by the European Society of Clinical Microbiology and Infectious Diseases (EUCAST) seems to be the second most frequently used method overall, but it is the preferred method in the most recent publications (2000–2019) for the interpretation criteria. Erythromycin has been proved to be the preference for resistance testing over the years. However, in the last 19 years, the antibiotics ciprofloxacin (CIP), erythromycin (ERM), levofloxacin (LEV) and azithromycin (AZM) were the ones that saw an increase in their use. A decrease in the sensitivity to antibiotics was identified in approximately half of the reviewed articles.

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