Epidemiological Surveillance of Amyotrophic Lateral Sclerosis in Saguenay Region

Lareau-Trudel, Emilie; Fortin, Élizabeth; Gauthier, Marianne; Lavoie, Sarah; Morissette, Érika; Mathieu, J.

doi:10.1017/s0317167100014955

Cited by 10 publications

(9 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Retrospective data on ALS incidence spanning at least 10 years are available from some geographic areas with conflicting results, indicating stability [12][13][14][15][16][17] or an increase. [18][19][20][21][22] These differences are likely to be related to the largely different methods of case ascertainment, the assessment of different periods, and the use of diverse diagnostic criteria. Besides the PARALS, the Irish ALS register, which is the only prospective epidemiologic register that has been constantly active for more than 10 years, reported an increase of ALS incidence in the 1996 to 2014 period, limited to patients older than 75 years and without evidence of a differential increase in the 2 sexes.…”

Section: Discussionmentioning

confidence: 99%

Secular Trends of Amyotrophic Lateral Sclerosis

Chiò

Mora²,

Moglia

et al. 2017

JAMA Neurol

View full text Add to dashboard Cite

IMPORTANCE This study reports the long-term epidemiologic trends of amyotrophic lateral sclerosis (ALS) based on a prospective register. OBJECTIVE To examine the 20-year epidemiologic trends of ALS in the Piemonte and Valle d'Aosta regions of Italy. DESIGN, SETTING, AND PARTICIPANTS The Piemonte and Valle d'Aosta Register for ALS (PARALS) is an epidemiologic prospective register that covers 2 Italian regions (population of 4 476 931 inhabitants according to the 2011 census) from January 1, 1995, through December 31, 2014. Case ascertainment is based on multiple sources (neurologic departments, hospital discharge archives, and mortality records). Incidence rates are age and sex standardized for the Italian population of the 2011 census. Age-period-cohort (APC) analysis was performed using a Poisson regression model. MAIN OUTCOMES AND MEASURES The primary study outcomes were long-term incidence and prevalence rates of ALS using a prospective design and their determinants. RESULTS During the study period, a total of 2702 patients (mean [SD] age at onset, 65.7 [11.1] years; 1246 [46.1%] female and 1456 [53.9%] male) received a diagnosis of ALS between 1995 and 2014, corresponding to a crude annual incidence rate of 3.03 per 100 000 population (95% CI, 2.85-3.23) and an adjusted incidence rate of 2.78 per 100 000 population (95% CI, 2.57-2.96). The age-adjusted incidence rate increased in the 2 decades of

show abstract

Section: Discussionmentioning

confidence: 99%

Secular Trends of Amyotrophic Lateral Sclerosis

Chiò

Mora²,

Moglia

et al. 2017

JAMA Neurol

View full text Add to dashboard Cite

show abstract

“…They found a rate of 3.01 per 100,000 per year for the five-year window-second only in quantity and timing to the BC data. 30 It could be that more recent measurements of ALS numbers reflect a time of greater incidence or better case ascertainment. In the present study, as highlighted in the Supplemental Data, incidence increases each year from 2010 through to 2014 and then decreases during 2014.…”

Section: Discussionmentioning

confidence: 99%

“…Another possibility for why BC numbers are more substantial could merely be reflective of the window of time in which they were measured. The closest window of Canadian data studied comes from a Quebec regional study 30 where 2005-2009 disease incidence was captured. They found a rate of 3.01 per 100,000 per year for the five-year window—second only in quantity and timing to the BC data 30 .…”

Section: Discussionmentioning

confidence: 99%

Five-Year Incidence of Amyotrophic Lateral Sclerosis in British Columbia (2010-2015)

Golby

Poirier

Fabros

et al. 2016

Can. J. Neurol. Sci.

View full text Add to dashboard Cite

Background: Amyotrophic lateral sclerosis (ALS) is a fatal degenerative neurological disease with significant effects on quality of life. International studies continue to provide consistent incidence values, though complete case ascertainment remains a challenge. The Canadian population has been understudied, and there are currently no quantitative data on the incidence of ALS in British Columbia (BC). The objectives of this study were to determine the five-year incidence rates of ALS in BC and to characterize the demographic patterns of the disease. Methods: The capture-recapture method was employed to estimate ALS incidence over a five-year period (2010)(2011)(2012)(2013)(2014)(2015). Two sources were used to identify ALS cases: one database from an ALS medical centre and another from a not-forprofit ALS organization. Results: During this time period, there were 690 incident cases within the two sources. The capture-recapture method estimated 57 unobserved cases, corresponding to a crude five-year incidence rate of 3.29 cases per 100,000 (CI 95% = 3.05-3.53). The mean age of diagnosis was 64.6 (CI 95% = 59.7-69.4), with 63.5 (CI 95% = 56.9-70.1) for men and 65.7 (CI 95% = 58.6-72.7) for women. There was a slight male preponderance in incidence, with a 1.05:1 ratio to females. Peak numbers in incidence occurred between the ages of 70 and 79. Conclusions: The incidence of ALS in BC was found to be consistent with international findings though nominally higher than that in other Canadian provinces to date. RÉSUMÉ: Taux d'incidence de la sclérose latérale amyotrophique en Colombie-Britannique de 2010 à 2015. Contexte: La sclérose latérale amyotrophique (SLA) est une maladie neurologique dégénérative qui à terme cause la mort et dont les effets sur la qualité de vie sont notables. Bien que des études internationales continuent de fournir des données cohérentes quant à l'incidence de la SLA, une évaluation complète de cette maladie demeure toujours un défi. À cet égard, la population canadienne n'a pas été suffisamment étudiée ; il n'existe pas non plus, à l'heure actuelle, de données quantitatives en ce qui regarde l'incidence de la SLA en Colombie-Britannique (C.-B.). L'objectif de cette étude a donc été de déterminer sur cinq ans le taux d'incidence de la SLA en C.-B. et de caractériser les aspects démographiques de cette maladie. Méthodes: Nous avons utilisé la méthode de capture-recapture pour estimer l'incidence de la SLA sur une période de cinq ans (2010)(2011)(2012)(2013)(2014)(2015). Pour ce faire, nous avons exploré deux bases de données, l'une produite par un centre médical spécialisé et l'autre par une organisation sans but lucratif, afin de relever des cas de SLA. Résultats: Au cours de cette période, ces deux bases de données ont révélé 690 cas. La méthode de capture-recapture a aussi estimé que 57 cas n'avaient pas été observés, ce qui correspond, sur cinq ans, à un taux d'incidence brut de 3,29 cas pour 100 000 (IC95% = 3,05 -3,53). L'âge moyen au moment du diagnostic était de 64,6 ans (IC...

show abstract

“…The study in the current issue by Lareau-Trudel et al describes epidemiologic surveillance of ALS in the Saguenay-Lac-St-Jean region of Quebec (SLSG) 4 . The authors report similar clinical features of ALS to those observed in the literature, but they also report a significant increase in incidence rate of ALS among the > 65 years-old group between the 1985-2004 and the 2005-2009 periods.…”

Section: Editorialmentioning

confidence: 99%