Epidemiological Surveillance of Lyme Borreliosis in Bavaria, Germany, 2013–2020

Böhmer, Merle M.; Ens, Katharina; Böhm, Stefanie; Heinzinger, Susanne; Fingerle, Volker

doi:10.3390/microorganisms9091872

Cited by 18 publications

(22 citation statements)

References 30 publications

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“…The expansion is influenced by several factors, climate change being the most relevant [ 4 ]. The most common clinical manifestation of LB is erythema migrans, a localised skin lesion, occurring in more than 90% of all reported LB cases [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Epidemiology of Lyme borreliosis based on outpatient claims data of all people with statutory health insurance, Germany, 2019

Akmatov¹,

Holstiege²,

Dammertz³

et al. 2022

Eurosurveillance

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Introduction Evidence of nationwide and regional morbidity of Lyme borreliosis (LB) in Germany is lacking. Aims We calculated the total number of incident LB cases in Germany in 2019, compared regional variations, investigated the extent of possible under-reporting in notification data and examined the association between high incidence areas and land cover composition. Methods We used outpatient claims data comprising information for people with statutory health insurance who visited a physician at least once between 2010 and 2019 in Germany (n = 71,411,504). The ICD-10 code A69.2 was used to identify incident LB patients. Spatial variations of LB were assessed by means of Global and Local Moran’s Index at district level. Notification data were obtained for nine federal states with mandatory notification from the Robert Koch Institute (RKI). Results Of all insured, 128,177 were diagnosed with LB in 2019, corresponding to an incidence of 179 per 100,000 insured. The incidence varied across districts by a factor of 16 (range: 40–646 per 100,000). We identified four spatial clusters with high incidences. These clusters were associated with a significantly larger proportion of forests and agricultural areas than low incidence clusters. In 2019, 12,264 LB cases were reported to the RKI from nine federal states, while 69,623 patients with LB were found in claims data for those states. This difference varied considerably across districts. Conclusions These findings serve as a solid basis for regionally tailored population-based intervention programmes and can support modelling studies assessing the development of LB epidemiology under various climate change scenarios.

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Section: Introductionmentioning

confidence: 99%

Epidemiology of Lyme borreliosis based on outpatient claims data of all people with statutory health insurance, Germany, 2019

Akmatov¹,

Holstiege²,

Dammertz³

et al. 2022

Eurosurveillance

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“…3 PhD Programme "Epidemiology", Braunschweig-Hannover, Germany. 4 German Center for Infection Research (DZIF), Braunschweig, Germany. 5 Hannover Medical School (MHH), Hannover, Germany.…”

Section: Fundingmentioning

confidence: 99%

“…In addition, yearly incidence between certain regions varies enormously; for example, in 2017 and within Mecklenburg-Western Pomerania, over 160 cases per 100,000 persons were reported in the west, and less than 40 cases per 100,000 persons were reported in the east. Moreover, changes over time have also been observed recently; Lyme borreliosis incidence in Bavaria, for instance, increased from 23.2 per 100,000 inhabitants in 2015 to 47.4 per 100,000 inhabitants in 2020 [ 4 ]. In all, the picture is highly heterogeneous regarding information from different data sources, regions and time.…”

Section: Introductionmentioning

confidence: 99%

Regional seropositivity for Borrelia burgdorferi and associated risk factors: findings from the Rhineland Study, Germany

et al. 2022

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Background Lyme borreliosis is the most prevalent vector-borne disease in Europe, and numbers might increase due to climate change. However, borreliosis is not notifiable in North Rhine-Westphalia (NRW), Germany. Hence, little is known about the current human seroprevalence in NRW. However, the proportion of Borrelia burgdorferi sensu lato-infected ticks has increased in a NRW nature reserve. The literature suggests increasing age and male sex as risk factors for seropositivity, whereas the influence of socioeconomic status is controversial. Thus, we aimed to determine regional seropositivity for Borrelia burgdorferi sensu lato (B. burgdorferi s.l.) and its risk factors in the Rhineland Study population in Bonn, NRW, and to compare it with previous surveys to evaluate potential effects of climate change. Methods We assessed seropositivity in 2865 Rhineland Study participants by determining immunoglobulin G (IgG) and immunoglobulin M (IgM) antibodies for B. burgdorferi s.l. using a two-step algorithm combining enzyme-linked immunosorbent assay tests and line immunoblots. We calculated the odds of being classified as IgG or IgM positive as a function of age, sex, and educational level using binomial logistic regression models. We applied varying seropositivity classifications and weights considering age, sex and education to compensate for differences between the sample and regional population characteristics. Results IgG antibodies for B. burgdorferi s.l. were present in 2.4% and IgM antibodies in 0.6% of the participants (weighted: 2.2% [IgG], 0.6% [IgM]). The likelihood of IgG seropositivity increased by 3.0% (95% confidence interval [CI] 1.5–5.2%) per 1 year increase in age. Men had 1.65 times the odds for IgG seropositivity as women (95% CI 1.01–2.73), and highly educated participants had 1.83 times the odds (95% CI 1.10–3.14) as participants with an intermediate level of education. We found no statistically significant link between age, sex, or education and IgM seropositivity. Our weighted and age-standardized IgG seroprevalence was comparable to the preceding serosurvey German Health Interview and Examination Survey for Adults (DEGS) for NRW. Conclusions We confirmed that increasing age and male sex are associated with increased odds for IgG seropositivity and provide evidence for increased seropositivity in the highly educated group. B. burgdorferi s.l. seropositivity remained constant over the past decade in this regional German population. Graphical abstract

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“…Хворобу Лайма зазвичай лікують антибіотиками, хоча повідомлялося про стійкість до них.Зараз золотим стандартом виявлення хвороби Лайма (ХЛ) є серологічна діагностика, заснована переважно на тестах ІФА та Вестерн-блот (ВБ). Проте, на початковій фазі інфекції через настання так званого періоду серологічного вікна, велике значення приділяється вивченню особливостей генетичного профілю, підтвердженню молекулярними методами -полімеразно-ланцюговою реакцією (ПЛР), що є більш чутливою та специфічною [3]. Генетичну ідентичність ізольованих спірохет визначали шляхом аналізу послідовностей генів, ампліфікованих за допомогою ПЛР на основі гена міжгенного спейсерного амплікона 5S (rrf)-23S (rrl) Borrelia burgdorferi sensu lato [4].Філогенетичний аналіз показав, що ці виявлені спірохети генетично пов'язані з геновидами Borrelia garinii та Borrelia afzelii з високою гомологією послідовностей у геновидах B. garinii (91,0-98,7 %) та B. afzelii (97 %).…”

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Комплекс Lyme Borrelia – Клінічний Набір Геномних Видів

Никитюк¹,

Климнюк²,

Левенець³

et al. 2022

ЗКЕМ

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РЕЗЮМЕ. Лайм-бореліоз (LB) – це бореліозна інфекція, спричинена кліщами, інфікованими трьома видами Borrelia: B. afzelii, B. garinii та B. burgdorferi sensu stricto. Передається укусами кліщів. Метою статті є обговорення генетичних методів обстеження при підозрі на Лайм бореліоз. Матеріал і методи. Пошук літератури в системі MEDLINE та базі даних Scopus. Результати. Генетичну ідентичність ізольованих борелій пропонується визначати шляхом аналізу послідовностей генів, ампліфікованих за допомогою ПЛР. Ген OspC здатний до горизонтальної передачі, що призводить до величезного різноманіття новосинтезованих кодованих ним білків. Це дозволяє спірохеті утворити нові антигенні епітопи, щоб уникнути імунної відповіді хазяїна. Висновки. Штами B. burgdorferi sensu stricto демонструють високу генетичну гетерогенність.

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Epidemiological Surveillance of Lyme Borreliosis in Bavaria, Germany, 2013–2020

Cited by 18 publications

References 30 publications

Epidemiology of Lyme borreliosis based on outpatient claims data of all people with statutory health insurance, Germany, 2019

Epidemiology of Lyme borreliosis based on outpatient claims data of all people with statutory health insurance, Germany, 2019

Regional seropositivity for Borrelia burgdorferi and associated risk factors: findings from the Rhineland Study, Germany

Комплекс Lyme Borrelia – Клінічний Набір Геномних Видів

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