Epidemiological Update on Solvent Neurotoxicity

Mikkelsen, Sigurd

doi:10.1006/enrs.1997.3706

Cited by 62 publications

(29 citation statements)

References 37 publications

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“…ese results suggest that occupational exposures to solvents may be associated later in life with cognitive impairment, even a er taking into account the e ects of education, employment grade, and numerous health factors [66]. Chronic low-level occupational exposure to organic solvents may have a negative impact on cognitive and psychological functioning [9,23,67].…”

Section: Discussionmentioning

confidence: 98%

Effects of long-term low-level solvent exposure on cognitive function

Saygun

Ekici²,

Muluk³

et al. 2012

CIM

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TurkeyE ects of long-term low-level solvent exposure on cognitive function Abstract Purpose: e e ects of long-term low-level exposures to solvents on cognitive function were investigated.Methods: A total of 389 workers at a gun factory, those exposed to solvents (n=193) and those that were not exposed to solvents during work (n=196), were included. All the workers were given a questionnaire. Cognitive function was evaluated by Mini-mental Status Examination (MMSE) and psychological status was assessed by Hospital Anxiety and Depression (HAD) Scale. Results:No di erences were found in the MMSE and HAD scores between solventexposed workers and control workers (p>0.05). In the workers who had used a mask for a longer time, orientation scores were lower. Daytime sleepiness was related to lower recall scores.. Le -handed workers had higher total HAD scores than right-handed workers.Conclusions: Long-term low-level exposure to solvents did not a ect cognitive function in the workers, according to their MMSE scores. Duration of solvent exposure was also not related to MMSE Scores. Short sleep duration and daytime sleepiness may negatively a ect cognitive function.

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Section: Discussionmentioning

confidence: 98%

Effects of long-term low-level solvent exposure on cognitive function

Saygun

Ekici²,

Muluk³

et al. 2012

CIM

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“…Occupational exposure to organic solvents, which constitute a large heterogeneous class of chemicals, may produce adverse, neurotoxic effects (Mikkelsen, 1997;White & Proctor, 1997). Only a few studies on rodents have addressed the detailed time course of brain concentrations of solvents during inhalation exposure, the most common way of ambient exposure to volatile compounds (Bruckner & Peterson, 1981;Benignus et al, 1981;Kishi et al, 1988;Warren et al, 1998).…”

mentioning

confidence: 99%

Relationship between Olive Oil:Air, Saline:Air, and Rat Brain:Air Partition Coefficients of Organic Solvents In Vitro

Meulenberg¹,

Wijnker²,

Vijverberg³

2003

Journal of Toxicology and Environmental Health, Part A

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“…According to several researches, solvent-exposed workers are frequently showed significantly compromised attention, processing speed, and working memory deficits compared to demographically similar unexposed controls. 4,5) The few neuroimaging studies to document neural structures affected by exposure to solvents demonstrated that solvents-exposed subjects showed significantly lower activation of anterior frontal areas and significantly worse performance on the working memory task than did controls. 6,7) Haut and colleagues studied the pattern of neural activation during verbal working memory in patients with solvent exposure using [ 15 O] water positron emission tomography (PET).…”

Section: Introductionmentioning

confidence: 99%

The Neural Alteration according to Cognitive Load on Working Memory by Organic-Solvent Exposures

et al. 2015

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cc This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Organic solvents are known toxic effects like vertigo, behavioral obstacle, distracting, and peripheral neuropathy in neuron areas. However, there have been few studies how neurotoxic solvents-exposed workers are affected by the cognitive load of preceding working memory tasks. Therefore, we used fMRI as to measure the neural correlates of working memory impairment in occupational workers who had from chronic exposure to organic solvent. Twenty-nine solvent-exposed workers were included in this study. Each participant concluded the verbal N-back tasks (1-and 2-back) during the fMRI acquisition. Within-group analyses showed fronto-parietal networks were active in each condition. Direct comparisons between 1-and 2-back showed higher activation during the 2-back than 1-back. We found that increased activation of these regions at lower task demand is associated with increased cost of implementing.

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Epidemiological Update on Solvent Neurotoxicity

Cited by 62 publications

References 37 publications

Effects of long-term low-level solvent exposure on cognitive function

Effects of long-term low-level solvent exposure on cognitive function

Relationship between Olive Oil:Air, Saline:Air, and Rat Brain:Air Partition Coefficients of Organic Solvents In Vitro

The Neural Alteration according to Cognitive Load on Working Memory by Organic-Solvent Exposures

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