Epidemiologically characteristics of human brucellosis and antimicrobial susceptibility pattern of Brucella melitensis in Hinggan League of the Inner Mongolia Autonomous Region, China

Yuan, Haitao; Wang, Chengling; Liu, Lina; Wang, Dan; Li, Dan; Li, Zhenjun; Liu, Zhiguo

doi:10.1186/s40249-020-00697-0

Cited by 33 publications

(24 citation statements)

References 38 publications

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“…Seasonality features included an incidence peak in March to August. Moreover, the 50–59-year-old age group had more cases; the ratio of males to females of 3.40:1 was similar to the results of previous studies 16 , 23 . Another study showed that a total of 1149 human brucellosis data points were collected during 2014–2018 in Huludao (China), with a mean age of 49.59 ± 13.14 years, and 75.7% were male 24 .…”

Section: Discussionsupporting

confidence: 90%

“…Isolation and culture of clinical strains were performed according to standard procedures in a biological safety II (p2) laboratory 16 . Briefly, five (~ 10 mL) blood samples were collected from each suspected patient and injected into a biphasic culture bottle (Germany, bioMérieux; China, Barrett Biotechnology (Zhengzhou) Co., Ltd.) in biosafety combination and incubated at 37 °C with 5% CO 2 for 2–4 weeks.…”

Section: Methodsmentioning

confidence: 99%

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Changes in the epidemiological characteristics of human brucellosis in Shaanxi Province from 2008 to 2020

Chen

Liu

Nie

et al. 2021

Sci Rep

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In the present study, surveys of case numbers, constituent ratios, conventional biotyping, and multilocus sequence typing (MLST) were applied to characterize the incidence rate and epidemiological characteristics of human brucellosis in Shaanxi Province, China. A total of 12,215 human brucellosis cases were reported during 2008–2020, for an annual average incidence rate of 2.48/100,000. The most significant change was that the county numbers of reported cases increased from 36 in 2008 to 84 in 2020, with a geographic expansion trend from northern Shaanxi to Guanzhong, and southern Shaanxi regions; the incidence rate declined in previous epidemic northern Shaanxi regions while increasing each year in Guanzhong and southern Shaanxi regions such as Hancheng and Xianyang. The increased incidence was closely related to the development of large-scale small ruminants (goats and sheep) farms in Guanzhong and some southern Shaanxi regions. Another significant feature was that student cases (n = 261) were ranked second among all occupations, accounting for 2.14% of the total number of cases, with the majority due to drinking unsterilized goat milk. Three Brucella species were detected (B. melitensis (bv. 1, 2, 3 and variant), B. abortus bv. 3/6, and B. suis bv. 1) and were mainly distributed in the northern Shaanxi and Guanzhong regions. Three known STs (ST8, ST2, and ST14) were identified based on MLST analysis. The characteristics that had not changed were that B. melitensis strains belonging to the ST8 population were the dominant species and were observed in all nine regions during the examined periods. Strengthened human and animal brucellosis surveillance and restriction of the transfer of infected sheep (goats) as well as students avoiding drinking raw milk are suggested as optimal control strategies.

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Section: Discussionsupporting

confidence: 90%

Section: Methodsmentioning

confidence: 99%

Changes in the epidemiological characteristics of human brucellosis in Shaanxi Province from 2008 to 2020

Chen

Liu

Nie

et al. 2021

Sci Rep

Self Cite

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“…This may be due to the fact that most of the population entering the province from abroad is the working population who aged 20-60, so the incidence of malaria in this age group is signi cantly affected by COVID-19. The results also showed that the incidence of brucellosis in the age group > 20 years was lower than during the same period of previous four years, while the incidence of brucellosis in the age group < 20 years was still within the range of that documented during the same period of previous four years,This may be due to the higher prevalence of brucellosis among farmers [27], and the age of farmers are mainly > 20 years, so the people in this age group were more likely to be affected by COVID-19. Moreover, we found that the incidence of HF in the age group of 20-50 years was lower than that of the same period during the previous four years, this is because the incidence of HF is mainly in the age group of 20-60 years, young and middle-aged farmers have more eld work and have greater exposure to rats and their pollutants.…”

Section: Discussionmentioning

confidence: 58%

The Impact of Intervention to Routine Surveillance of Natural Focal Diseases During the Outbreak of COVID-19 in Jiangsu Province, China

Cheng

Luo³

et al. 2020

Preprint

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Background: With the strength intervention of China, the outbreak of Severe Acute Respiratory Syndrome-Coronavirus 2 (SARS-CoV-2) had a great control effect. The measures may influence the development and progression of others infectious diseases.Method: The data of daily coronavirus virus disease 2019 (COVID-19) confirmed cases from January 3, 2020 to April 30, 2020 and natural focal disease cases from January, 2005 to April, 2020 were collected from Jiangsu Provincial Center for Disease Control and Prevention (Jiangsu Provincial CDC). We describe and compare the data of natural focal diseases from January to April, 2020 with the same months from 2015 to 2019 in the four aspects: trend of incidence, regional, age and sex distribution. Nonparametric tests were used to analyzed to the difference between the duration from onset of illness to date of diagnosis of natural focal diseases and the same period of the previous year. Results: The incidence of malaria in February (0.9 per 10,000,000 people), March (0.3 per 10,000,000 people) and April (0.1 per 10,000,000 people) 2020 less than the lower limit for range of February (1.6-4.5 per 10,000,000 people), March (0.8-3.3 per 10,000,000 people) and April (1.0-2.9 per 10,000,000 people) from 2015 to 2019 respectively. The incidence of brucellosis in February was 0.9 (per 10,000,000 people), less than the lower limit for the range from 2015 to 2019 (1.6-4.5 per 10,000,000 people). The incidence of hemorrhagic fever (HF) in March was 1.0 (per 10,000,000 people), less than the lower limit for the range from 2015 to 2019 (1.4-2.6 per 10,000,000 people). However, the incidence of Severe Fever with Thrombocytopenia Syndrome (SEFT) in March was 0.3 (per 10,000,000 people), higher than the upper limit for the range from 2015 to 2019 (0.0-0.1 per 10,000,000 people). Furthermore, we respectively observed the incidence with various degree of reduction in male, 20-60 years old and both rural and urban areas. Conclusions: In Jiangsu province, the incidence of natural focal diseases decreased during the outbreak of COVID-19 in 2020, especially malaria, HF and SEFT. The impact of interventions were felt most by male individuals within the age group of 20-50 years. The interventions for COVID-19 may control the epidemics of natural focal diseases.

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“…Our results were similar to many other pieces of literature reported from other provinces or cities in China. 5 , 22 , 23 …”

Section: Discussionmentioning

confidence: 99%

“…Our results were similar to many other pieces of literature reported from other provinces or cities in China. 5,22,23 The conclusion drawn from previous studies, the positive rates of brucellosis from blood cultures had a wideranged from 16% to 90%. 24 This was consistent with the current study of 46.8% positive rate and mostly were discovered in the acute phase of brucellosis.…”

mentioning

confidence: 95%

Epidemiological, Clinical and Laboratory Characteristics of Patients with Brucella Infection in Anhui Province, China

Shi¹,

Wang²,

Lv³

et al. 2021

IDR

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Background: Brucellosis is currently one of the most widespread zoonotic diseases caused by Brucella genus, and the Brucella melitensis is the major pathogen. The number of people infected with Brucella has gradually increased in Anhui Province. Purpose: To retrospectively evaluate the epidemiological, clinical, and laboratory data of brucellosis patients in Anhui Province. Patients and Methods: A total of 109 brucellosis patients were admitted to the First Affiliated Hospital of Anhui Medical University from January 2012 to March 2021. Data from all patients were retrieved from the hospital's electronic medical system. The final results were grouped and compared according to the presence or absence of bacteremic brucellosis and three phases of brucellosis. Results: The most common symptoms among all 109 brucellosis patients were fever (89.0%), followed by chills (52.3%), arthralgia (48.6%), and weight loss (30.3%), and laboratory results presented with anemia (65.1%), elevate of C-reactive protein (CRP) (91.7%), erythrocyte sedimentation rate (ESR) (86.2%), aspartate aminotransferase (AST) (40.4%), and lactate dehydrogenase (LDH) (43.1%). The percentage of fever (96.1%), arthralgia (58.8%), anorexia (35.3%), leukopenia (31.4%), and the AST (51.0%) were higher in bacteremic than nonbacteremic group. Additionally, the median level of LDH (332.0 mg/ L, IQR, 209.0-553.0) was higher in bacteremic than nonbacteremic group. Nevertheless, the albumin (36.0 mg/L, IQR, 33.9-38.2) was lower in the bacteremic group. The percentage of fever (94.9%) and the median LDH level (316.0 U/L (IQR,218.0-517.5)) in the acute phase of brucellosis were higher than the percentage of fever (72.0%) and the median LDH level (209.0 U/L (IQR,162.0-276.0)) in the subacute phase of brucellosis. Conclusion: Brucellosis has become an important public health issue in Anhui Province. Brucellosis is a disease with diverse clinical manifestations. Our data showed that unexplained fever, arthralgia, and elevated AST and LDH should be considered as a diagnosis of bacteremia brucellosis for early treatment intervention.

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Epidemiologically characteristics of human brucellosis and antimicrobial susceptibility pattern of Brucella melitensis in Hinggan League of the Inner Mongolia Autonomous Region, China

Cited by 33 publications

References 38 publications

Changes in the epidemiological characteristics of human brucellosis in Shaanxi Province from 2008 to 2020

Changes in the epidemiological characteristics of human brucellosis in Shaanxi Province from 2008 to 2020

The Impact of Intervention to Routine Surveillance of Natural Focal Diseases During the Outbreak of COVID-19 in Jiangsu Province, China

Epidemiological, Clinical and Laboratory Characteristics of Patients with Brucella Infection in Anhui Province, China

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