Épidémiologie et cycle parasitaire d’un fléau mondial, le paludisme

Argy, Nicolas; Houzé, Sandrine

doi:10.1016/j.actpha.2018.01.004

Cited by 3 publications

(2 citation statements)

References 14 publications

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“…Le même rapport renseigne que la zone de santé d'Alunguli seule a eu une proportion de 4,6 % ; ce qui représente 51,9 % des femmes enceintes atteintes, soit 1516 cas de paludisme sur 2920 femmes enceinte de la zone de santé (PNLP/MMA, 2020). Bien que le paludisme frappe indistinctement toutes les catégories sociales, la situation de la femme enceinte est préoccupante compte tenu de sa particulière complexité tant physiologique que sociale (Argy & Houzé, 2018).…”

Section: Introduction I1 Contexte D'étude Et Problématiqueunclassified

Connaissance Du Paludisme Chez Les Femmes Enceintes De La Zone De Sante D’alunguli/Kindu

NORBERT¹,

KETIBWA

ROMAIN

et al. 2023

IJRHSN

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Malaria is on of the most serious health problems despite the existence of preventive and curatuive measures. Nearly 40% of the world’s population is exposed to this parasitosis. This research is carried out through a cross-descriptive approach correlating it. We used the survey method, supported by the interview technique guided by a simple questionnaire. To analyze our data, we used calculations of the arithmetic mean ; stadard deviation, coefficient of variation, Student t test, Snedecor’s F ratio and multivariate regression. The summary of the results is as follows : Overall, knowlodge of malaria among pregnant women in the health zone of Alunguli is insufficient. The yield reflecting this knowledge is less than 50%. This invalidated the first hypothesis. The variable age, parity, level of education, marittal status and health area of residence of the subjects did not influence knowledge of malaria. Therefore, are not determinants of it. This invalidated the second hypothesis.

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Section: Introduction I1 Contexte D'étude Et Problématiqueunclassified

Connaissance Du Paludisme Chez Les Femmes Enceintes De La Zone De Sante D’alunguli/Kindu

NORBERT¹,

KETIBWA

ROMAIN

et al. 2023

IJRHSN

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“…Malaria is one of the world's most important parasitic endemic diseases, and about 3.2 billion people are at risk of being infected worldwide. The most affected regions are Africa, Asia, Latin America, and the Middle East [1,2]. In 2019, the World Health Organization (WHO) estimated that malaria is responsible for approximately 241 million cases and 627 thousand deaths worldwide [3].…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Khaya grandifoliola Stem Bark Ethanol Extract in the Treatment of Cerebral Malaria in Swiss albino Mice Using Plasmodium berghei NK65 Strain

Guy-Armand,

Cedric,

Nadia

et al. 2023

Journal of Parasitology Research

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Background. Cerebral malaria is one of the most severe and dangerous forms of malaria and is potentially fatal. This study was aimed at evaluating the anticerebral malaria efficacy of Khaya grandifoliola used by traditional healers. Method. Fifty grams of Khaya grandifoliola stem bark was macerated in 1 L ethanol (95%) for 72 h. The filtrate was dried at 40°C until the obtention of a dry extract. The antimalarial test was evaluated using the Peter 4-day suppressive test and the Rane curative test. Mice were group into 6 groups of 6 mice each. For the antioxidant test, parameters such as malondialdehyde (MDA), superoxide dismutase (SOD), glutathione (GSH), catalase (CAT), and nitric oxide (NO) were assessed. The livers of mice were crushed and centrifuged in order to be measured. Aspartate aminotransferase (ASAT) and alanine aminotransferase (ALAT) using the Dutch Diagnostics Kit and blood were collected for haematological parameters. Results. The ethanol extract showed a suppressive activity of 78.12%, 75.30%, and 68.69% at 500 mg/kg, 250 mg/kg, and 125 mg/kg, respectively. Similarly, the curative activity showed a statistically significant reduction in parasitemia ( p < 0.05 ). Antioxidant parameter assays showed a low value of MDA and a high value of SOD, CAT, NO, and GSH in the negative control group. A statistically significant higher values of ASAT and ALAT were observed in the negative control compared to the other test groups ( p < 0.05 ). Haematological parameters showed a statistically significant decrease in white blood cells, red blood cells, haemoglobin, and platelets in the negative control group ( p < 0.05 ). Conclusion. The results of this study justify the traditional usage of Khaya grandifoliola in the treatment of cerebral malaria. However, in vivo toxicity assessment is still necessary to verify its safeness.

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Chimioprophylaxie du paludisme

Fougere

2019

Actualités Pharmaceutiques

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Épidémiologie et cycle parasitaire d’un fléau mondial, le paludisme

Cited by 3 publications

References 14 publications

Connaissance Du Paludisme Chez Les Femmes Enceintes De La Zone De Sante D’alunguli/Kindu

Connaissance Du Paludisme Chez Les Femmes Enceintes De La Zone De Sante D’alunguli/Kindu

Efficacy of Khaya grandifoliola Stem Bark Ethanol Extract in the Treatment of Cerebral Malaria in Swiss albino Mice Using Plasmodium berghei NK65 Strain

Chimioprophylaxie du paludisme

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