Épidémiologie et diagnostic des leucémies aiguës à l’hôpital Ravoahangy Andrianavalona Antananarivo Madagascar

Nirina, Marie Osé Michael Harioly; Rakotoarivelo, Z.; Ntoezara, A.; Rasolonjatovo, Anjaramalala Sitraka; Rakoto-Alson, A.O.; Rasamindrakotroka, A.

doi:10.1007/s12558-015-0393-6

Cited by 4 publications

(4 citation statements)

References 14 publications

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“…La LAM était la première forme de leucémie aigüe. Cette constatation est en conformité avec celle d'autres études menées par d'autres auteurs Africains (10,(27)(28). La majorité des LAM (10 cas sur 18) étaient de type 5 selon la classification FAB ( 14), tandis que les LAM de type 2 sont les plus fréquentes dans la littérature occidentale (29).La cytologie tient une place importante dans le diagnostic des leucémies aigues et l'étude d'autres marqueurs non disponibles dans notre milieu telles que la cytogénétique, l'immunophenotypage et la biologie moléculaire qui sont devenues indispensables pour une meilleure prise en charge diagnostique, pronostique et thérapeutique.…”

Section: Définitions Opérationnelles Et Des Conceptsunclassified

Hémopathies malignes de l’adulte à Kinshasa : analyse documentaire d’une série des cas de 2011 à 2021

Diasonama,

Wameso,

Lebwaze

et al. 2023

Ann. Afr. Med

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Context and Objective. Hematological malignancies (HMs) are a major public health problem in Sub-Saharan Africa where the means of management are limited. The objective of the study was to describe the diagnostic, therapeutic and evolutionary features observed in the management of HMs in the Kinshasa hospital setting. Methods. This was an observational historical cohort study involving records of patients with HMs attending 3 hospitals in Kinshasa, between January 1st, 2011 and 31st December 2021. Only patients over the age of 18 were included. The parameters of interest were socio-demographic, the results of myelogram, histopathological analysis of lymph node biopsy or extra lymph node biopsy parts, imaging results and biological assessment, the type of chemotherapy and outcome survival for the first 6 months. The groups were compared using the Khi-Square and Student's t-tests as appropriate. Kaplan Meier curve was used to describe survival. Factors associated with survival were assessed by Cox’s regression analysis. Results. Out of 2678 patients suspected of HM, only 250 patients (9,3 %, average age 47, 6 ± 15,8 years, 62,4 % of men) had a confirmation assessment. Peripheral lymphadenopathy (54 %), long-term fever (48 %) and polytransfusion (29 %) were the main reasons for consultation. Main abnormalities were anemia (72 %), thrombocytopenia (50 %), hyperleukocytosis (30 %) and leukopenia (30%). Lymphoproliferative syndromes (68 %) were more common and distributed into non-Hodgkin lymphomas (50 %), Hodgkin lymphoma (27 %) and multiple myeloma (15 %). Acute leukemia was second (12 %) followed by myelodysplastic syndromes (11%) and myeloproliferative syndromes (8 %). 61 % of patients received chemotherapy. During the first 6 months of management, the overall lethality was 58,4 %. Conclusion. In the Kinshasa hospital setting, very few HM suspect patients benefit from a complete assessment and treatment. Young adults, especially men, are very affected and more than half of them die within 6 months. Improving access to chemotherapy and the technical platform will reduce lethality. Contexte et objectif. Les hémopathies malignes (HM) constituent un problème majeur de santé publique en Afrique sub-saharienne où les moyens de prise en charge sont limités. L’objectif de l’étude était de décrire les aspects diagnostiques, thérapeutiques et évolutifs observées dans la prise en charge des HM en milieu hospitalier de Kinshasa. Méthodes. Etude observationnelle historique de type suivi des cas d’HM hospitalisés, dans formations sanitaires de Kinshasa entre les 1er janvier 2011 et 31 décembre 2021. Seuls les patients âgés de plus de 18 ans ont été inclus. Les paramètres d’intérêt étaient englobés les données sociodémographiques, cliniques, biologiques, d’imagerie, du myélogramme, de l’analyse histopathologique des pièces biopsiques ganglionnaires ou extra ganglionnaires, le type de chimiothérapie et de la survie à 6 mois. Les tests de chi-carré et de Student ont comparé respectivement les proportions et les moyennes. L’analyse de Kaplan Meier et la régression de Cox ont respectivement décrit la survie et recherché les facteurs associés à la mortalité à 6 mois. Résultats.Sur 2678 patients suspects d’HM, seuls de 250 patients (9,3%, âge moyen 47,6 ± 15,8 ans, 62,4% d’hommes) ont eu un bilan de confirmation. Les adénopathies périphériques (54 %), la fièvre au long cours (48 %) et la poly transfusion (29 %) étaient les principaux motifs de consultation. Les perturbations hématologiques rencontrées étaient l’anémie (72 %), la thrombopénie (50 %), l’hyperleucocytose ( 0 %) et la leucopénie ( 0 %). Les syndromes lymphoproliferatif (68 %) étaient plus fréquents et répartis en lymphomes non hodgkiniens (50 %), Lymphome hodgkinien (27%) et myélome multiple (15 %). Les leucémies aigues venaient en deuxième position (12 %) suivi des syndromes myélodysplasiques (11 %) et des syndromes myéloprolifératifs (8 %). 61 % des patients ont bénéficié de la chimiothérapie. Durant les 6 premiers mois de prise en charge, la létalité globale était de 58,4 %. Conclusion. En milieu hospitalier de Kinshasa, très peu de patients suspects d’HM bénéficient d’une mise au point complète et de la chimiothérapie. Les adultes jeunes, surtout les hommes, sont très affectés et plus de la moitié d’entre eux décèdent endéans 6 mois. L’amélioration de l’accessibilité à la chimiothérapie et du plateau technique permettra une réduction de la létalité.

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Section: Définitions Opérationnelles Et Des Conceptsunclassified

Hémopathies malignes de l’adulte à Kinshasa : analyse documentaire d’une série des cas de 2011 à 2021

Diasonama,

Wameso,

Lebwaze

et al. 2023

Ann. Afr. Med

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“…Leukemia can develop from lymphoid or myeloid cells and is generally classified as acute if cells are in an early stage of differentiation [1] . According to a study conducted in the Pediatric Hematology-Oncology Department of Abderrahim Harouchi Hospital Casablanca, Morocco between January 2006 and December 2013, of 142 cases of acute leukemia, acute lymphoblastic leukemia (ALL) represented 89.5 % of cases [2] .…”

Section: Introductionmentioning

confidence: 99%

Assessment of oral health-related quality of life among children with acute leukemia

Bensouda¹,

Elgasmi²,

Jalil³

et al. 2020

SDS

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Aim: To assess the impact of oral health on the quality of life in children with acute leukemia. Methods: Forty children (age 11 to 14 years) with acute leukemia from the Pediatric Oncology and Hematology Departments of the 20th August Hospital Casablanca and the Pediatrics Department P3 at Abderrahim Harouchi Hospital Casablanca, Morocco were surveyed. Data was collected via an administered questionnaire. The questionnaire is a translated version of the Child-Oral Impacts of Daily Performance Questionnaire in Arabic (validated in Morocco). Results: The most commonly reported problems were: dental tartar, teeth position abnomalities, tooth decay, dental sensitivity and oral ulcerations. The overall prevalence of oral problems impacting upon daily activities (eating, speaking, cleaning teeth, relaxing, sleeping, smiling, showing teeth, studying and being in touch with other children) over the last 3 months was 52.5%. The most frequently affected daily activity was eating difficulties (45%) while the most frequently reported problem was oral ulcerations. Conclusion: Studies have confirmed that children over the age of 11 are able to perceive their general and oral health as well as its impact on their daily lives. The current study showed that oral problems on top of general health complications among children with acute leukemia lead to a deterioration in their quality of life, which is already affected by malignancy and chemotherapy.

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“…Depending on the line concerned, they are subdivided into acute myeloid leukaemia (AML) and acute lymphoblastic leukaemia (ALL). 4 In children, 80% of acute leukaemia is called lymphoid or lymphoblastic (ALL). Of these cases, 80% are LALs of line B (affecting the development of B lymphocytes), called common.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Clinical, Biological and Evolutionary Characteristics Between Childhood Acute Lymphoblastic and Myeloid Leukemia in Western Algeria, From 2016 to 2018

Beghdoud

Youcef

Diaf

et al. 2020

J. Drug Delivery Ther.

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Background and Objectives: Haematological malignancies account for approximately 40% of all cancers by the age of 15 years. Acute leukaemia (AL) account for one-third of childhood cancer cases; consisting of Acute Lymphoblastic Leukaemia (ALL) and Acute Myeloid Leukaemia (AML). The aim of this work is to describe the epidemiological, clinical, biological and evolutionary characteristics of children with acute leukaemia in the western and south-western region of Algeria. Patients and Methods: A three-year retrospective study was undergone from January 2016 to December 2018 on children with acute leukaemia. The study was conducted at the paediatric oncology department of the anti-cancer -Emir AEK- of Missreghine in Oran. Results: During this period, we identified 135 cases of diagnosed AL. The sex ratio M/F was 1.1. The “two to five-year” age group was the most affected. The prevalence of ALL, AML, and biphenotypic acute leukaemia (BAL) was 60.45%, 23.88%, and 15.57%, respectively. The clinical signs were mainly presented by the tumour syndrome dominated by the presence of lymphadenopathy (63%) and splenomegaly (56.3%). The most frequent abnormal blood abnormalities were anaemia (66.66% in ALL and 28.14% in AML), thrombocytopenia (75.9% in ALL and 24.4% in AML) and leukocytosis (76.3% ALL and 23.7% AML). Conclusion: Paediatric acute leukaemia is a real public health problem that requires special care and attention. This management must involve all epidemiological, clinical and biological aspects for this highly sensitive age group.

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Épidémiologie et diagnostic des leucémies aiguës à l’hôpital Ravoahangy Andrianavalona Antananarivo Madagascar

Cited by 4 publications

References 14 publications

Hémopathies malignes de l’adulte à Kinshasa : analyse documentaire d’une série des cas de 2011 à 2021

Hémopathies malignes de l’adulte à Kinshasa : analyse documentaire d’une série des cas de 2011 à 2021

Assessment of oral health-related quality of life among children with acute leukemia

Comparison of Clinical, Biological and Evolutionary Characteristics Between Childhood Acute Lymphoblastic and Myeloid Leukemia in Western Algeria, From 2016 to 2018

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