Epidemiologisch-klinische Charakteristika von Patienten mit zystischer Echinokokkose

Orhun, Arzu; Müller-Stöver, Irmela; Holtfreter, Martha C.; Dedelen, H.; Häussinger, Dieter; Richter, Joachim

doi:10.1055/s-0032-1304951

Cited by 9 publications

(10 citation statements)

References 11 publications

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“…The reactivity of rural inhabitants to Echinococcus antigens was significantly greater compared to urban dwellers, which confirms the views of Romig et al(2003) Bobić et al (2012) and Orhun et al (2012). The ELISA results obtained in the current study showed a decrease in seropositive reactions with age, and did not confirm the view of the greatest frequency of echinococcosis in older people (Torgerson, 2013).…”

Section: Percent Of Positivesupporting

confidence: 58%

Evaluation of reactivity to Echinococcus spp. among rural inhabitants in Poland

Cisak

Sroka

Wójcik-Fatla

et al. 2015

Acta Parasitologica

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A group of 172 rural inhabitants from eastern Poland (68 males and 104 females, mean age 49.0 ± 12.0 years) was examined for the presence of antibodies against Echinococcus granulosus and Echinococcus multilocularis. A population of 38 healthy urban dwellers from the city of Lublin (17 males and 21 females, mean age 36.2 ± 9.6 years) were examined as a control group. Sera of 22 rural inhabitants (12.8%) reacted positively to Echinococcus granulosus hydatid fluid antigen in the screening test. A cross-reactivity was observed with two serum samples that tested positive in ELISA for E. granulosus. Three serum samples were tested positive for E. multilocularis using the Em2plus ELISA assay and also positive for Western blot. None of the members of control group showed the presence of a seropositive reaction to Echinococcus spp. The reactivity to Echinococcus spp. among rural inhabitants decreased with age and this correlation was statistically significant (R = -0.197151, p = 0.009535). The percentage of positive findings was the highest (50.0%) in the youngest age group (14-20). No significant correlations were found between responses to interview questions (possession of domestic and farm animals, contact with wild animals, eating unwashed berries, drinking unboiled water) and the presence of seropositive reactions to Echinococcus spp. The presented results seem to indicate that echinococcosis is still a current problem in Poland that should not be neglected and, moreover, indicates the need for improvement in the routine laboratory diagnostics of Echinococcus spp. by standardizing the ELISA and Western blot tests.

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Section: Percent Of Positivesupporting

confidence: 58%

Evaluation of reactivity to Echinococcus spp. among rural inhabitants in Poland

Cisak

Sroka

Wójcik-Fatla

et al. 2015

Acta Parasitologica

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“…This is not uncommon for countries characterized by high immigration rates. For example, in a study conducted in Germany, only nine out of 65 cystic echinococcosis cases were of German origin [ 63 ]. In another German study, AE was diagnosed in a refugee from an endemic area (e.g.…”

Section: Human Infections With Echinococcus Multilocularis mentioning

confidence: 99%

Echinococcus multilocularisin North America: the great unknown

et al. 2014

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Over the last decade, studies have begun to shed light on the distribution and genetic characterization of Echinococcus multilocularis, the causative agent of alveolar echinococcosis (AE), in North America. Recent findings indicate that the parasite is likely expanding its range in the central region of the United States and Canada and that invasions of European strains might have occurred. In our review, we present the available data on E. multilocularis infections in wild and domestic animals and humans in North America and emphasize the lack of knowledge on the distribution of the parasite in wild and domestic hosts. Furthermore, we stress the need to better understand the complexity of host communities and their roles in shaping the transmission and distribution of the parasite. We hypothesize that a lack of knowledge about AE by North American physicians might result in the misdiagnosis of cases and an underestimation of disease incidence. The endemic presence of the parasite in urban areas and a recent human case in Alberta, Canada, suggest that the scientific community may need to reconsider the local public health risks, re-assess past cases that might have been overlooked and increase surveillance efforts to identify new cases of human AE.

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“…Furthermore, the present study reveals more detailed epidemiological and clinical data which are helpful for further steps in the future control and management of CE in Albania (Casulli et al 2022). From the experience of other studies, it results that hospital records largely underreport CE cases as compared to populationbased surveys (Budke et al 2006;Casulli et al 2022;Orhun et al 2012;Richter et al 2019). Anyhow, from our data results that there is a decrease of cases over the last 10 years which is likely to be due to the high emigration rate from rural areas and urbanization of the Albanian population.…”

Section: Discussionmentioning

confidence: 62%

“…Rural areas with most intensive sheep raising are likely to be the places of most intensive transmission such as the rural areas of Gjirokastër, Kukës and Dibër counties. Surgery rate in the three case series was between 84% and 91%, a very high rate in comparison with other endemic countries (Orhun et al 2012;Velasco-Tirado et al 2018). Although there is no unique gold standard therapy for complex clinical cases such as CE, the high surgery rate suggests that other therapy options are rarely considered.…”

Section: Discussionmentioning

confidence: 81%

What do we know about the epidemiology and the management of human echinococcosis in Albania?

Luga

Gjata²,

Mino³

et al. 2023

Preprint

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Echinococcosis is a life-threatening neglected zoonotic disease. Cystic echinococcosis (CE) due to Echinococcus (E.) granulosus usually involves livestock and dogs, alveolar echinococcosis (AE) due to E. multilocularis involves rodents and canines such as foxes and dogs. Humans hosts are infected accidentally via hand to mouth and/or foodborne/waterborne pathways. Albania is deemed to be endemic for cystic echinococcosis (CE) but there is a scarcity of data to confirm this. A systematic literature search was performed in PubMed, Google Scholar and in other medical sources. Because of the scarcity of existing information data confirming CE cases were reviewed from the medical hospital records Albania`s largest Hospital, the Mother Teresa University Hospital (UHCMT) Tirana and from a large private laboratory in Tirana (Pegasus laboratory). Only 8 eligible publications on 540 CE patients were found. Further 347 cases hospitalized in UHCMT from 2011 to 2020, 36 laboratory cases and 10 Albanian cases notified in Germany were confirmed. Taking all cases into account and considering 162 overlapping cases, 771 cases are documented from 2005 to 2020. The only AE case reported was most likely a multi-organic CE. The most frequent therapy approach used was surgery (84.7%). Autochthonous human CE seems to be common and transmission is ongoing in Albanian. CE patients undergo surgery more frequently as compared with CE cases in other European countries. To enable the control of echinococcosis in Albania, obligatory notification should be re-established. In CE, stage specific therapy enables to reduce therapy cost and mortality by avoiding surgical overtreatment.

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Epidemiologisch-klinische Charakteristika von Patienten mit zystischer Echinokokkose

Cited by 9 publications

References 11 publications

Evaluation of reactivity to Echinococcus spp. among rural inhabitants in Poland

Evaluation of reactivity to Echinococcus spp. among rural inhabitants in Poland

Echinococcus multilocularisin North America: the great unknown

What do we know about the epidemiology and the management of human echinococcosis in Albania?

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