Epidemiology and aetiology of basal cell carcinoma

Roewert-Huber, Joachim; Lange‐Asschenfeldt, Bernhard; Stockfleth, Eggert; Kerl, Helmut

doi:10.1111/j.1365-2133.2007.08273.x

Cited by 212 publications

(214 citation statements)

References 61 publications

(107 reference statements)

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“…[14][15][16][17] In most studies, male sex is reported as predominant, however in our patients the opposite was observed. 6,8,16,18 BCC represented over two thirds of all NMSC and predominated over SCC on all skin areas, except for the lower lip and the genital area. In the former, SCC predominance is probably explained by its particular anatomic disposition, nearly perpendicular to the solar radiation, potentiating the effect of UV light.…”

Section: Discussionmentioning

confidence: 99%

“…2,3,5 Multiple risk factors have been described for NMSC, but chronic exposure to ultraviolet radiation, particularly UV-B, is clearly the most important, progressively inducing keratinocyte carcinogenesis and resulting in BCC or SCC after several years or decades of cumulative cellular degeneration. 2,3,6,7,8 However, BCC and SCC do not arise randomly in a chronically sun-exposed skin as the pattern of UV exposure seems to play a role: many studies have shown that SCC is frequently associated with long term chronic UV-exposure, while BCC is associated with intense intermittent UV-exposure. 2,5,6 The reason why these two patterns of sun-exposure seem to act differently in the skin has not been identified yet.…”

Section: Introductionmentioning

confidence: 99%

“…1,2 Additionally, iatrogenic or cosmetic artificial UV skin irradiation, exposure to ionizing radiation or other carcinogenic agents in the environment and immunesuppression may also increase the risk of NMSC in some particular cases. [1][2][3][4][5][6][7][8] In what concerns the SCC, smoking and oncogenic HPV infection have also been identified as important risk factors, particularly for the perioral and genital areas. 6 Some rare genodermatosis such as xeroderma pigmentosum, oculocutaneous albinism, epidermodysplasia verruciformis and Gorlin-Glotz syndrome, may also be associated with some cases of NMSC.…”

Section: Introductionmentioning

confidence: 99%

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Epidemiology of basal cell carcinomas and squamous cell carcinomas in a Department of Dermatology: a 5 year review

Andrade¹,

Brites²,

Vieira³

et al. 2012

An. Bras. Dermatol.

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BACKGROUND: Non-melanoma skin cancer, a common designation for both basal cell carcinomas and squamous cell carcinomas, is the most frequent malignant skin neoplasm. OBJECTIVE: Epidemiologic characterization of the population with Non-melanoma skin cancer. METHODS: Retrospective analysis of all patients diagnosed with Non-melanoma skin cancer based on histopathologic analysis of all incisional or excisional skin biopsies performed between 2004 and 2008 in a Department of Dermatology. RESULTS: A total of 3075 Non-melanoma skin cancers were identified, representing 88% of all malignant skin neoplasms (n=3493) diagnosed in the same period. Of those, 68,3% were basal cell carcinomas. Most Non-melanoma skin cancer patients were female and over 60 years old. Of all Non-melanoma skin cancer, 81,7% (n=1443) were located in sun-exposed skin, and represented 95,1% of malignant skin neoplasms in sun-exposed skin. Non-melanoma skin cancer was the most frequent malignant skin neoplasm in most topographic locations, except for abdomen and pelvis - over 95% of all malignant skin neoplasms in the face, neck and scalp were Non-melanoma skin cancer. Basal cell carcinomas were clearly predominant in all locations, except in upper and lower limbs, lower lip and genitals, where squamous cell carcinomas represented respectively 77,7%, 77,4%, 94,7% and 95,3% of the Non-melanoma skin cancers. CONCLUSION: Being the most common skin cancer, Non-melanoma skin cancer should be under constant surveillance, in order to monitor its epidemiologic dynamics, the efficiency of preventive measures and the adaptation of the healthcare resources.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Epidemiology of basal cell carcinomas and squamous cell carcinomas in a Department of Dermatology: a 5 year review

Andrade¹,

Brites²,

Vieira³

et al. 2012

An. Bras. Dermatol.

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“…Epidemiological data (5,6,8,9,(11)(12)(13)(14)(15)(16) show clearly that ultraviolet (UV) radiation, particularly UVB, is an essential etiological factor in the carcinogenesis of skin tumors. UV exposure is a chronic oxidative stress (17) that causes DNA damage with specific mutations of suppressor genes such as p53 (14,16,(18)(19)(20)(21)(22): it is activated along with telomerase (23)(24)(25)(26)(27).…”

Section: Introductionmentioning

confidence: 99%

Localization of telomerase hTERT protein in frozen sections of basal cell carcinomas (BCC) and tumor margin tissues

Fabricius

Kruse-Boitschenko²,

Khoury³

et al. 2009

Int J Oncol

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Abstract.In previous studies we demonstrated telomerase activity in frozen tissues from BCC and their tumor-free margins by the PCR ELISA. In this study we examined in the same frozen sections immunohistochemical presence of hTERT in the nucleus. After fixation in acetone and methanol followed by steaming we used for visualization the antigenantibody reactions by APAAP. This was the best method of preparation of the frozen sections in our preliminary hTERT-study with squamous cell carcinomas. This study was supplemented with antibodies against Ki-67, nucleolin, common leucocyte antigen CD45 and mutated p53. The immunoreactive scores were determined and included the comparison with telomerase activity. The investigation of hTERT expression was performed in the tissues of 41 patients with BCC and control tissues of 14 patients without tumor. Eleven commercial antibodies were used for a nuclear staining of hTERT expression. With the anti-hTERT antibodies we looked for both satisfactory distribution and intensity of immunohistochemical labeling in the carcinomas and in the squamous epithelia of the tumor centers, of the tumor-free margins and of the control tissues. The hTERT expression in the BCC was distributed heterogeneously. The score values established by the anti-hTERT antibodies used were variably or significantly increased. In the stroma they tended to be negative, so we disregarded stroma hTERT. Proof of hTERT did not differ uniformly from telomerase activity. We compared the high with the lower median hTERT values in the Kaplan-Meier curve. Patients with lower hTERT scores in the center or tumor margin as shown by some of the antibodies suffered relapse earlier. Finally, we compared the hTERT expression in BCC tissues with the hTERT scores in HNSCC tissues from our previous study. Only one anti-hTERT antibody (our Ab 7) yielded significantly higher scores in BCC than in HNSCC.

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“…Its cumulative risk in the Caucasian population is over 30% and its incidence has been increasing worldwide at an annual rate of 3-7%, constituting a public health issue. 1,2 The reasons for this increase in frequency are yet to be fully clarified; however, they may involve the increased awareness of the population regarding the condition and improvements in the training of professionals to establish diagnosis at earlier stages; longer unprotected exposure to ultraviolet radiation and more leisure time; a culture that idealizes tanned skin; depletion of the ozone layer; increased longevity and the consequent proportional rise in the elderly segment of the population. 3 The treatment of choice continues to be surgical removal of the lesion, which also facilitates the retrieval of computerized data from pathology services, enabling these data to be correlated with demographic indicators and with the demands on the healthcare system.…”

confidence: 99%

Aumento da incidência de carcinoma basocelular em hospital universitário: 1999 a 2009

Schmitt

Chinem²,

Marques

et al. 2011

An. Bras. Dermatol.

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A incidência do carcinoma basocelular vem aumentando em todos os países. Realizou-se estudo ecológico de 5169 laudos de carcinoma basocelular, da FMB-Unesp, entre janeiro/1999 e dezembro/2009. O incremento médio da incidência para o período foi de 90,6%, projetando-se um diagnóstico para cada 15 pacientes encaminhados à dermatologia. Tal tendência se manteve, mesmo quando indexada pelo número de laudos histopatológicos, movimento hospitalar, atendimentos da dermatologia e população de Botucatu.

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Epidemiology and aetiology of basal cell carcinoma

Cited by 212 publications

References 61 publications

Epidemiology of basal cell carcinomas and squamous cell carcinomas in a Department of Dermatology: a 5 year review

Epidemiology of basal cell carcinomas and squamous cell carcinomas in a Department of Dermatology: a 5 year review

Localization of telomerase hTERT protein in frozen sections of basal cell carcinomas (BCC) and tumor margin tissues

Aumento da incidência de carcinoma basocelular em hospital universitário: 1999 a 2009

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