Epidemiology and Aetiology of Non-melanoma Skin Cancer

Cancer diseases are one of the biggest health threats of the last two decades. Approximately 9% of all diagnosed cancers are skin cancers, including melanoma and non-melanoma. As in all cancer cases, early diagnosis is essential to achieve efficient treatment. New solutions and advanced techniques for rapid diagnosis are constantly being sought. Aptamers are single-stranded RNA or DNA synthetic sequences or peptides, which offer novel possibilities to this area of research by specifically binding selected molecules, the so-called cancer biomarkers. Nowadays, they are widely used as diagnostic probes in imaging as well as in targeted therapy. In this review, we have summarized the recently made advances in diagnostics and therapy of skin cancers, which have been achieved by combining aptamers with basic or modern technologies.

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Aptamer-based Advances in Skin Cancer Research

Piasek

Musolf

Sobiepanek

2023

CMC

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Evaluation of residual tumors and recurrence rates of malignant melanoma and non-melanoma skin cancer of head and neck region

Kocaaslan¹,

Alakus²,

Saçak³

et al. 2019

Marmara Medical Journal

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Objective: In this study, we aimed to evaluate residual tumors and recurrence rates of malignant melanoma (MM) and a nonmelanoma skin cancer of (NMSC) head and neck region. Patients and Methods: Medical data of a total of 398 lesions of 323 patients who underwent surgical excision for a basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and malignant melanoma (MM) were retrospectively analyzed. All patients were classified according to age, sex, location of the tumor, histopathological diagnosis, lesion diameter, excision diameter, surgical margin status, and residual lesions and recurrence rates. Results: There were 244 lesions (61.3%) in 189 males and 154 lesions (38.7%) in 134 females. The most common type of skin cancer was BCC in 268 lesions (67%), followed by SCC in 122 (31%), and MM in eight (2%), respectively. Recurrence was seen in 3% of the NMSC cases and in 25% of the MM cases. There was a statistically significant correlation between the histopathological diagnosis and recurrence rates. Compared to NMSC, MM cases had a higher risk for recurrence (p=0.029). Conclusion: Our study results suggest that recurrence is associated with the localization and type of the tumor, but not with the age or sex of the patient.

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Epidemiology and Aetiology of Non-melanoma Skin Cancer

Cited by 2 publications

References 48 publications

Aptamer-based Advances in Skin Cancer Research

Aptamer-based Advances in Skin Cancer Research

Evaluation of residual tumors and recurrence rates of malignant melanoma and non-melanoma skin cancer of head and neck region

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