Epidemiology and Antimicrobial Sensitivities of 536 Multi-Drug-Resistant Gram-Negative Bacilli Isolated from Patients Treated on Surgical Wards

Maraki, Sofia; Mavros, Michael N.; Kofteridis, Diamantis P.; Samonis, George; Falagas, Matthew E.

doi:10.1089/sur.2011.115

Cited by 17 publications

(10 citation statements)

References 36 publications

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“…[24], [32] Also, previous studies have shown high in vitro activity of colistin against MDR P . aeruginosa isolates, [33], [34] while treatment with colistin resulted in sufficient clinical effectiveness when administered to patients with severe infections due to MDR P . aeruginosa [35], [36], [37].…”

Section: Discussionmentioning

confidence: 99%

Determination of MIC Distribution of Arbekacin, Cefminox, Fosfomycin, Biapenem and Other Antibiotics against Gram-Negative Clinical Isolates in South India: A Prospective Study

et al. 2014

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ObjectivesTo determine the in vitro activity of antibiotics, including arbekacin, cefminox, fosfomycin and biapenem which are all still unavailable in India, against Gram-negative clinical isolates.MethodsWe prospectively collected and tested all consecutive isolates of Escherichia coli, Klebsiella spp., Pseudomonas aeruginosa and Acinetobacter spp. from blood, urine and sputum samples between March and November 2012. The minimum inhibition concentration (MIC) of 16 antibiotics was determined by the broth micro-dilution method.ResultsOverall 925 isolates were included; 211 E. coli, 207 Klebsiella spp., 153 P. aeruginosa, and 354 Acinetobacter spp. The MIC50 and MIC90 were high for cefminox, biapenem and arbekacin for all pathogens but interpretative criteria were not available. The MIC50 was categorized as susceptible for a couple of antibiotics, including piperacillin/tazobactam, carbapenems and amikacin, for E. coli, Klebsiella spp. and P. aeruginosa. However, for Acinetobacter spp., the MIC50 was categorized as susceptible only for colistin. On the other hand, fosfomycin was the only antibiotic that inhibited 90% of E. coli and Klebsiella spp. isolates, while 90% of P. aeruginosa isolates were inhibited only by colistin. Finally, 90% of Acinetobacter spp. isolates were not inhibited by any antibiotic tested.ConclusionFosfomycin and colistin might be promising antibiotics for the treatment of infections due to E. coli or Klebsiella spp. and P. aeruginosa, respectively, in India; however, clinical trials should first corroborate the in vitro findings. The activity of tigecycline should be evaluated, as this is commonly used as last-resort option for the treatment of multidrug-resistant Acinetobacter infections.

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Section: Discussionmentioning

confidence: 99%

Determination of MIC Distribution of Arbekacin, Cefminox, Fosfomycin, Biapenem and Other Antibiotics against Gram-Negative Clinical Isolates in South India: A Prospective Study

et al. 2014

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“…Furthermore, both MDR and non-MDR A. baumannii isolates remained highly susceptible to colistin. Various reports from many countries, such as China, Greece, and Turkey have shown 21.5-84% of A. baumannii isolates during 1996-2009 were MDR A. baumannii and 94-100% of these isolates were susceptible to colistin 11,25,26 . Ninety-eight percent of MDR A. baumannii isolates were susceptible to colistin and had MIC 50 and MIC 90 values of 0.75 and 1 µg/ml, which were similar to those of previous studies from Dizbay 7,8,25 .…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial susceptibility of Acinetobacter baumannii isolated from hospital patients

Tunyapanit¹,

Pruekprasert²,

Laoprasopwattana³

et al. 2014

ScienceAsia

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ABSTRACT:The incidence of multidrug-resistant Acinetobacter baumannii (MDR A. baumannii) is increasing worldwide and is leading to therapeutic problems. We investigated the in vitro activities of cefoperazone/sulbactam, colistin, imipenem, and rifampicin alone and in double combinations against 100 A. baumannii isolates from patients at Songklanagarind Hospital in Songkhla Province, Thailand. The E-test method was used to determine antimicrobial susceptibility, the minimal inhibitory concentration (MIC) and for antimicrobial combination testing. A. baumannii isolates were susceptible to colistin (97%), cefoperazone/sulbactam (69%), imipenem (45%), and rifampicin (13%). Fifty-nine percent of them were MDR A. baumannii. Colistin was superior to cefoperazone/sulbactam, rifampicin and imipenem against MDR A. baumannii and the MIC50, MIC90 of colistin were 0.75 and 1 µg/ml, respectively. Non-MDR A. baumannii isolates were susceptible to cefoperazone/sulbactam (100%), colistin (95%), imipenem (93%) and rifampicin (2%). Combinations of cefoperazone/sulbactam plus colistin or rifampicin, imipenem plus colistin or rifampicin and colistin plus rifampicin showed indifferent effects against most MDR isolates. Of all the antimicrobial combinations tested, cefoperazone/sulbactam plus rifampicin produced the highest percentages (42%) of synergy, partial synergy, and additive results. The activity rate of cefoperazone/sulbactam against MDR A. baumannii was higher when combined with rifampicin than colistin. Thus colistin had the greatest activity against most MDR and non-MDR A. baumannii isolates among all of the antibiotics tested. Cefoperazone/sulbactam and imipenem showed good activity against non-MDR isolates, and cefoperazone/sulbactam combined with rifampicin may be useful in treating infections caused by MDR isolates.

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“…In general, gentamicin is active against various gram-positive and gram-negative bacteria, such as Staphylococcus spp (including methicillin-resistant S aureus), Escherichia coli, Klebsiella pneumoniae, Enterobacter spp, Pseudomonas aeruginosa, and Acinetobacter spp; however, resistant strains have developed and disseminated. 20,21 A common finding among all reviewed trials was the relatively high incidence of postoperative SWI (2.5%-9%). Although numerous modalities (preoperative topical antiseptics, eradication of S aureus carriage, intravenous prophylaxis, topical application of antibiotics, and others) have been tried, the SWI rate has not decreased significantly.…”

Section: Discussionmentioning

confidence: 99%

“…22 In addition, it has been claimed that the standard antimicrobials used may need to be reconsidered in this era of advancing antimicrobial resistance. 21,23 Furthermore, differences in the antimicrobial formulations used (ie, generic vs original cefuroxime) may have an impact on the development of SWI. 24 Other strategies that may aid in reducing SWI rates include strict glucose management, nasopharyngeal decontamination with mupirocin, skin decontamination with chlorhexidine showers, and topical application of antibiotics (ie, bacitracin or vancomycin) postoperatively.…”

Section: Discussionmentioning

confidence: 99%

Gentamicin collagen sponges for the prevention of sternal wound infection: A meta-analysis of randomized controlled trials

Mavros

Mitsikostas

Alexiou

et al. 2012

The Journal of Thoracic and Cardiovascular Surgery

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Epidemiology and Antimicrobial Sensitivities of 536 Multi-Drug-Resistant Gram-Negative Bacilli Isolated from Patients Treated on Surgical Wards

Abstract: In a region with a high prevalence of antibiotic resistance, almost one-half of GNB isolated from surgical patients were MDR. Surgeons may consider these developments to guide empiric antibiotic therapy for infections caused by gram-negative pathogens.

Cited by 17 publications

References 36 publications

Determination of MIC Distribution of Arbekacin, Cefminox, Fosfomycin, Biapenem and Other Antibiotics against Gram-Negative Clinical Isolates in South India: A Prospective Study

Determination of MIC Distribution of Arbekacin, Cefminox, Fosfomycin, Biapenem and Other Antibiotics against Gram-Negative Clinical Isolates in South India: A Prospective Study

Antimicrobial susceptibility of Acinetobacter baumannii isolated from hospital patients

Gentamicin collagen sponges for the prevention of sternal wound infection: A meta-analysis of randomized controlled trials

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