Epidemiology and characteristics of sickle cell patients admitted to hospitals in Jazan region, Saudi Arabia

Hazzazi, Ahmad Ali; Ageeli, Mohssen H.; Alfaqih, Abdulaziz Mohammed; Jaafari, Abdullah Ali; Malhan, Hafiz; Bakkar, Mohammed

doi:10.4103/joah.joah_67_19

Cited by 35 publications

(37 citation statements)

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“…In this study, 16 cases had ischemic strokes. This prevalence is higher compared to the findings of the study done in Jazan, which had only two cases in their sample [ 25 ]. Other individuals might suffer from silent strokes that are only discovered on radiological testing consistent with diffuse white matter disease [ 27 ].…”

Section: Discussioncontrasting

confidence: 73%

“…Iron overload, tissue infarction, and functional asplenia can result in immunodeficiency, which puts them at a higher risk of developing it [24]. A total of 23 cases were found in our sample, which is higher compared to a recent multicenter study conducted in Jazan (22 cases), including pediatrics and adult patients with SCA [25].…”

Section: Discussioncontrasting

confidence: 54%

“…Up to 50% of patients with SCD suffer from chronic pain due to AVN [ 28 ]. In this study, 13 patients were diagnosed with AVN, which is higher than the aforementioned study in Jazan (11 patients) [ 25 ].…”

Section: Discussionmentioning

confidence: 72%

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Risk Factors and Complications Among Pediatric Patients With Sickle Cell Anemia: A Single Tertiary Center Retrospective Study

Alzahrani¹,

Fallatah²,

Al-Haddad³

et al. 2021

Cureus

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Background and objective Sickle cell anemia (SCA) is one of the common genetic diseases in the Kingdom of Saudi Arabia (KSA). This disease results from a genetic mutation that causes malformation of the red blood cells (RBCs), leading to various systemic complications, including vaso-occlusive crisis (VOC), acute chest syndrome (ACS), osteomyelitis, avascular necrosis (AVN), and stroke, to name a few. The leading cause of mortality in SCA is these systemic complications rather than the disease itself. Understanding the risk factors of these complications can help reduce mortality in these patients and improve their quality of life. In this study, we aimed to determine the risk factors of SCA complications among pediatric patients with SCA at King Abdulaziz University Hospital (KAUH) in Jeddah, KSA. Methods This retrospective study was carried out from January 2012 till June end 2019. It was conducted among pediatric patients with SCA. Patients were screened for eligibility, and we excluded those with thalassemia and those who had a medical history of chronic diseases. Data were collected from patients’ electronic medical records. Results The study included 102 pediatric patients with SCA; their mean age was 7.88 ±4.22 years; almost half of them were females (56%) and 44% were males. The dominant body mass index (BMI) classification among them was normal (49%). Urinary tract infection (UTI) was the most common complication with 38 cases followed by VOC with 32 cases. Other complications observed were ACS (25.5%) followed by stroke (15.7%). HbSS was the most prominent genotype among these patients, and it was associated with a higher rate of complications. However, there was no significant relationship between genotype and patients developing complications. Finally, patients with high white blood cell (WBC) counts, elevated systolic blood pressure (SBP), and hypoxia developed more complications, and there was a significant relationship between these conditions and the development of complications (p<0.05). Conclusion Based on our findings, patients with high WBC count, elevated SBP, and hypoxia are at greater risk of developing complications. Accordingly, healthcare providers should consider putting in place all measures required to provide a good quality of life for these patients, including raising awareness about the risk factors that lead to these complications, appropriate immunizations, and precautionary measures to promote these patients' welfare.

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Section: Discussioncontrasting

confidence: 73%

Section: Discussioncontrasting

confidence: 54%

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Risk Factors and Complications Among Pediatric Patients With Sickle Cell Anemia: A Single Tertiary Center Retrospective Study

Alzahrani¹,

Fallatah²,

Al-Haddad³

et al. 2021

Cureus

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“…Studies have reported that SCD is highly prevalent in Saudi Arabia with an estimation of 0.5% for sickle cell trait (SCT) and 0.038% for SCD through the screening done by the premarital program. Newborn screening estimated a prevalence of 21% for SCT and 2.6% for SCD [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Prevalence and Predictive Factors for Leg Ulcers in Sickle Cell Disease Patients in Saudi Arabia: A Cross-Sectional Observational Study

Kaliyadan

Alkhars

Albaqshi

et al. 2020

Cureus

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Introduction Saudi Arabia has a high prevalence of sickle cell disease (SCD). Leg ulceration is one of the complications associated with SCD. There is a gap in the literature in regard to the prevalence of leg ulcers among SCD patients in Saudi Arabia. Objectives The primary objective of this study was to evaluate the lifetime prevalence of leg ulcers in SCD patients in our population and to study the predictive factors of leg ulcers by using sociodemographic factors, clinical manifestations of SCD, and other relevant factors like hydroxyurea. Methods A cross-sectional study design was utilized. Data collection was done using an electronic survey to collect self-reported information for the prevalence of leg ulcers and possible associated factors. The survey was distributed using social media platforms. Chi-square test was used to test for the presence of an association between having leg ulcers and sociodemographic variables as well as SCD related history. Furthermore, binary logistic regression was utilized to determine factors predicting the incidence of leg ulcers among SCD. Results A total of 790 valid responses were included in the study. Among these, 646 were included in the analysis of leg ulcers prevalence. From them, 52 (8%) SCD patients reported a history of leg ulcers. The male to female ratio was (9.7% vs 7.2%). The age group most affected by leg ulcers was those older than 50 (16.7%). There was no significant association between a history of leg ulcers and sociodemographic variables. The only predictive factors for leg ulcers were having six to eight vaso-occlusive crises per month and having more than eight vaso-occlusive crises per month. Conclusion Leg ulcers among SCD patients in Saudi Arabia were considerably prevalent (8%). There was no statistically significant correlation between leg ulceration and sociodemographic variables. Leg ulcers were more likely in patients with a history of highly frequent vaso-occlusive crises. No association was found between the incidence of leg ulcers and other complications of sickle cell disease or hydroxyurea.

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“…4 In a recently published study conducted in Jazan region, KSA, SCD was the most common cause of hospitals' admissions with a percentage of more than 20% of the total admissions in medicine and pediatric departments. 6 It is known that healthcare providers' attitudes toward patients can affect the quality of care as negative attitudes can be a barrier to proper pain management. [7][8][9] More respect and trust from physicians to sickle cell patients are believed to be associated with proper management and less frustration and mistrust among sickle cell patients.…”

Section: Et Almentioning

confidence: 99%

Physicians’ and nurses’ perceptions and attitudes toward sickle cell disease patients in Jazan, Saudi Arabia

Hazzazi

Ageeli

Sharahili

et al. 2020

SMJ

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To explore physicians' and nurses' perceptions and attitudes toward sickle cell patients in Jazan, Kingdom of Saudi Arabia (KSA). Methods: A cross-sectional study conducted in Jazan, KSA from November 2018 to March 2019. A convenience sample of nurses and physicians (N=244) from 12 hospitals in Jazan region completed the general perceptions about sickle cell disease patients scale questionnaire. Inferential statistics were conducted as appropriate to compare attitudes among groups within all variables. A p<0.05 was considered significant. Original Article Results: The response rate was 81%. The mean age was 33.73±7.89 years. Approximately, half of the participants were nurses (54.9%) and 40.8% were males. In comparison with physicians (39.6%), approximately two-thirds (65.7%) of nurses have more negative attitudes (p=0.000). Emergency healthcare providers have more negative attitudes than providers in the pediatric department (p=0.043). Those treating primarily children had higher positive attitude than those treating adults (p=0.013) or treating both, (p=0.017). Emergency providers (p=0.000), and internal medicine providers (p=0.001), had higher concern-raising behaviors' scale scores than pediatric providers. Conclusion: Findings highlight a significant proportion of providers in Jazan region, KSA, to have negative attitudes toward and high concerns about drug-seeking behaviors among sickle cell patients. These attitudes can contribute to lower quality of care for people with sickle cell disease. Further studies are recommended to find out the factors behind these attitudes as well as the adherence to guidelines in the management of sickle cell disease.

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Epidemiology and characteristics of sickle cell patients admitted to hospitals in Jazan region, Saudi Arabia

Cited by 35 publications

References 1 publication

Risk Factors and Complications Among Pediatric Patients With Sickle Cell Anemia: A Single Tertiary Center Retrospective Study

Risk Factors and Complications Among Pediatric Patients With Sickle Cell Anemia: A Single Tertiary Center Retrospective Study

Prevalence and Predictive Factors for Leg Ulcers in Sickle Cell Disease Patients in Saudi Arabia: A Cross-Sectional Observational Study

Physicians’ and nurses’ perceptions and attitudes toward sickle cell disease patients in Jazan, Saudi Arabia

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