Epidemiology and clinical characteristics of severe acute respiratory infections among hospitalized children under 5 years of age in a tertiary care center in Bangkok, Thailand, 2019–2020

Wanlapakorn, Nasamon; Thongpan, Ilada; Sarawanangkoor, Nasiri; Vichaiwattana, Preeyaporn; Auphimai, Chompoonut; Srimuan, Donchida; Thatsanathorn, Thaksaporn; Kongkiattikul, Lalida; Kerr, Stephen J.; Poovorawan, Yong

doi:10.1016/j.heliyon.2023.e22300

Heliyon

2023

DOI: 10.1016/j.heliyon.2023.e22300

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Epidemiology and clinical characteristics of severe acute respiratory infections among hospitalized children under 5 years of age in a tertiary care center in Bangkok, Thailand, 2019–2020

Nasamon Wanlapakorn,

Ilada Thongpan,

Nasiri Sarawanangkoor

et al.

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2024

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Cited by 4 publications

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Key Challenges to Understanding the Burden of Respiratory Syncytial Virus in Older Adults in Southeast Asia, the Middle East, and North Africa: An Expert Perspective

Günen,

Alzaabi,

Bakhatar

et al. 2024

Adv Ther

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Introduction Respiratory syncytial virus (RSV) is a common, highly contagious pathogen and a leading cause of serious illness among infants and older adults. While existing scientific evidence has predominantly focused on the epidemiology and disease burden of RSV in infants, data in older adults remain limited in some countries, including those in Southeast Asia (SEA) and the Middle East and North Africa (MENA) region. Here, we outline the key challenges for understanding the burden of RSV in older adults in SEA and the MENA region and we propose opportunities for improving understanding and eventually reducing the impact of RSV. Main Findings and Conclusions A key challenge identified by the expert group, particularly in older adults, is a lack of awareness (among healthcare professionals, policy makers, and the public) of RSV burden and the associated risks for severe outcomes. This is often confounded by the complexities of underdiagnosis, surveillance limitations, and comorbidities. To address these issues, we suggest medical education initiatives for physicians in SEA and the MENA region to better understand the need to protect older adults from RSV, and encourage more widespread routine testing to better understand the burden of RSV. We also recommend surveillance studies in these regions to provide comprehensive and accurate epidemiological data on RSV in older adults. Finally, in the absence of current surveillance data in these regions, we propose extrapolating existing global data and local pediatric data to inform the likely burden of RSV in older adults. A graphical abstract is available with this article. Graphical Abstract Supplementary Information The online version contains supplementary material available at 10.1007/s12325-024-02954-2.

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Key Challenges to Understanding the Burden of Respiratory Syncytial Virus in Older Adults in Southeast Asia, the Middle East, and North Africa: An Expert Perspective

Günen,

Alzaabi,

Bakhatar

et al. 2024

Adv Ther

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Quantitative distribution of antibiotic resistance genes and crAssphage in a tropical urbanized watershed

Sresung,

Srathongneam,

Paisantham

et al. 2024

Science of The Total Environment

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Seasonality and Co‐Detection of Respiratory Viral Infections Among Hospitalised Patients Admitted With Acute Respiratory Illness—Valencia Region, Spain, 2010–2021

Shirreff,

Chaves,

Coudeville

et al. 2024

Influenza Resp Viruses

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BackgroundRespiratory viruses are known to represent a high burden in winter, yet the seasonality of many viruses remains poorly understood. Better knowledge of co‐circulation and interaction between viruses is critical to prevention and management. We use > 10‐year active surveillance in the Valencia Region to assess seasonality and co‐circulation.MethodsOver 2010–2021, samples from patients hospitalised for acute respiratory illness were analysed using multiplex real‐time PCR to test for 9 viruses: influenza, respiratory syncytial virus (RSV), parainfluenza virus (PIV), rhino/enteroviruses (HRV/ENV), metapneumovirus (MPV), bocavirus, adenovirus, SARS‐CoV‐2 and non‐SARS coronaviruses (HCoV). Winter seasonal patterns of incidence were examined. Instances of co‐detection of multiple viruses in a sample were analysed and compared with expected values under a crude model of independent circulation.ResultsMost viruses exhibited consistent patterns between years. Specifically, RSV and influenza seasons were clearly defined, peaking in December–February, as did HCoV and SARS‐CoV‐2. MPV, PIV and HRV/ENV showed less clear seasonality, with circulation outside the observed period. All viruses circulated in January, suggesting any pair had opportunity for co‐infection. Multiple viruses were found in 4% of patients, with more common co‐detection in children under 5 (9%) than older ages. Influenza co‐detection was generally observed infrequently relative to expectation, while RSV co‐detections were more common, particularly among young children.ConclusionsWe identify characteristic patterns of viruses associated with acute respiratory hospitalisation during winter. Simultaneous circulation permits extensive co‐detection of viruses, particularly in young children. However, virus combinations appear to differ in their rates of co‐detection, meriting further study.

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Epidemiology and clinical characteristics of severe acute respiratory infections among hospitalized children under 5 years of age in a tertiary care center in Bangkok, Thailand, 2019–2020

Cited by 4 publications

References 38 publications

Key Challenges to Understanding the Burden of Respiratory Syncytial Virus in Older Adults in Southeast Asia, the Middle East, and North Africa: An Expert Perspective

Key Challenges to Understanding the Burden of Respiratory Syncytial Virus in Older Adults in Southeast Asia, the Middle East, and North Africa: An Expert Perspective

Quantitative distribution of antibiotic resistance genes and crAssphage in a tropical urbanized watershed

Seasonality and Co‐Detection of Respiratory Viral Infections Among Hospitalised Patients Admitted With Acute Respiratory Illness—Valencia Region, Spain, 2010–2021

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