Epidemiology and clinical characteristics of sarcoidosis: an update from a population-based cohort study from Olmsted County, Minnesota

Abstract

Summary Information about the epidemiology, clinical manifestations and comorbidities of sarcoidosis among Caucasians is relatively scarce. This review focuses primarily on the data from a recently published Caucasian-predominant population-based cohort from Olmsted County, Minnesota. Overall, the incidence rate was 10.0 per 100,000 population, which suggested that sarcoidosis is less common in Caucasians than in Blacks, but is more common in Caucasians than in Asians. Intrathoracic involvement was seen in the vast majority of patients, but less than half have respiratory symptoms. The most common extra-thoracic manifestations were skin rash followed by arthralgia, ophthalmologic involvement, hepatic involvement, splenomegaly, renal involvement, neurological involvement, extra-thoracic lymphadenopathy, exocrine gland involvement, upper respiratory tract involvement and cardiac involvement. Compared to sex and age-matched subjects, patients with sarcoidosis suffer from increased rates of cardiovascular disease, venous thromboembolism and hospitalized infection.

Sarcoidosis among hospitalized patients in Poland: a national hospital register-based study

“…However, sarcoidosis is still poor ly understood. 28 Our results suggest the pos sible contribution of environmental factors to the pathogenesis of sarcoidosis. We observed no significant time trend in the incidence of first time hospitalizations with sarcoidosis diagno sis and found significant differences in the inci dence of sarcoidosis by month.…”

A Comprehensive Review of Hepatic Sarcoid

“…8,38 As discussed previously, clinically evident hepatic involvement in systemic sarcoidosis ranges from 3.6 to 21%. [4][5][6][7][8]10 However, we know that true hepatic involvement, meaning granulomas present in the liver of those with systemic sarcoid, is much higher than this (on the order of 55-80%) based on liver biopsy and autopsy data. [39][40][41][42] When clinically active, hepatic sarcoid can range anywhere from asymptomatic, mild elevations in alkaline phosphatase (ALP) to cirrhosis and end-stage liver disease (ESLD) requiring liver transplantation (►Table 2).…”

Primary isolated hepatosplenic sarcoidosis mimicking malignancy and causing symptomatic hypercalcaemia

“…Sarcoidosis is a granulomatous disease that can affect any organ system 1. It is of unknown cause so far and it can affect individuals worldwide 1.…”

“…Sarcoidosis is a granulomatous disease that can affect any organ system 1. It is of unknown cause so far and it can affect individuals worldwide 1. It is characterised pathologically by the presence of non-caseating granulomas in involved organs 1.…”