Epidemiology and clinical features of amyotrophic lateral sclerosis in Ireland between 1995 and 2004

O’Toole, Orna; Traynor, Bryan J.; Brennan, Paul; Sheehan, Colm; Frost, Eithne; Corr, Bernie; Hardiman, Orla

doi:10.1136/jnnp.2007.117788

Cited by 173 publications

(119 citation statements)

References 11 publications

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“…A higher incidence of bulbar involvement in patients with an older age at disease onset has been reported in previous studies (18)(19)(20)(21)(22)(23). Increasing age at disease onset may be an important factor influencing the increasing percentage of bulbar onset ALS.…”

Section: Discussionmentioning

confidence: 73%

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Changes in the Clinical Features of Amyotrophic Lateral Sclerosis in Rural Japan

et al. 2013

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Objective To assess longitudinal changes in the clinical features of patients with amyotrophic lateral sclerosis (ALS), we performed a retrospective hospital-based study covering 35 years. Methods We investigated 287 patients (154 men and 133 women) with sporadic ALS hospitalized at the Department of Neurology at Gunma University Hospital (Japan) between 1978 and 2012. All patients fulfilled the diagnostic criteria for definitive, probable or laboratory-supported probable ALS according to the revised El Escorial criteria. Results Two hundred patients (69.7%) exhibited limb onset and 87 patients (30.3%) exhibited bulbar onset of the disease. The percentage of patients who showed bulbar onset of the disease increased steadily over the 35 years from 14.2% to 38.3% (2008-12) (p<0.01, r=0.470). The mean age at onset was 62.1 ± 11.7 years, and the age at onset increased significantly over time from 51.7 years (1978-82) to 64.9 years (2008-12) (p<0.001, r=0.294). In addition, the percentage of patients whose age at onset was 70 years or more increased from 0% (1978-82) to 38.2% . The percentage of ALS patients with dementia increased from 0% (1978-82) to 20.2% (2008-12). Conclusion Our findings demonstrate that, among patients with sporadic ALS, the age at disease onset, the proportion of patients with disease onset at 70 years of age or higher, the proportion of patients with dementia and the proportion of patients with bulbar onset ALS have increased significantly over the past 35 years. The longitudinal changes observed in the clinical features of ALS may reflect the increasing age at disease onset.

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Section: Discussionmentioning

confidence: 73%

“…The diagnosis of ALS is currently based on a combination has been reported (17)(18)(19)(20)(21)(22)(23)(24). These findings suggest that the epidemiology and clinical features of ALS may have changed over time.…”

Section: Introductionmentioning

confidence: 68%

Changes in the Clinical Features of Amyotrophic Lateral Sclerosis in Rural Japan

et al. 2013

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“…Immediately preceding death, there is a near total loss of limb and respiratory function, as well as a loss of the ability to chew, swallow, and speak. ALS is defined as an "orphan disease," with approximately 2 per 100,000 new cases per year and a prevalence of about 5 per 100,000 total cases each year (1). In the United States (2) and Europe (3,4), ALS is diagnosed in about 1 in 500 to 1 in 1,000 adult deaths, implying that 500,000 people in the United States will develop this disease in their lifetimes.…”

Section: Introductionmentioning

confidence: 99%

Emerging mechanisms of molecular pathology in ALS

Peters¹,

Ghasemi²,

Brown³

2015

J. Clin. Invest.

247

142

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“…The crude incidence of ALS for those aged 18 or over is estimated to be approximately 2.7 per 100,000 person-years in Europe [1]. The annual incidence in Ireland is about 2.6 per 100,000 [2], with approximately 110 new cases diagnosed annually.…”

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confidence: 99%

Age-period-cohort analysis of trends in amyotrophic lateral sclerosis incidence

et al. 2016

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Article:Tobin, K, Gilthorpe, MS orcid.org/0000-0001-8783-7695, Rooney, J et al. (4 more authors) (2016) Age-period-cohort analysis of trends in amyotrophic lateral sclerosis incidence. Journal of Neurology, 263 (10). pp. 1919-1926 https://doi.org/10.1007/s00415-016-8215-z © 2016, Springer-Verlag Berlin Heidelberg. This is an author produced version of a paper published in Journal of Neurology. Uploaded in accordance with the publisher's self-archiving policy.The final publication is available at Springer via http://dx.doi.org/10.1007/s00415-016-8215-z eprints@whiterose.ac.uk https://eprints.whiterose.ac.uk/ Reuse Unless indicated otherwise, fulltext items are protected by copyright with all rights reserved. The copyright exception in section 29 of the Copyright, Designs and Patents Act 1988 allows the making of a single copy solely for the purpose of non-commercial research or private study within the limits of fair dealing. The publisher or other rights-holder may allow further reproduction and re-use of this version -refer to the White Rose Research Online record for this item. Where records identify the publisher as the copyright holder, users can verify any specific terms of use on the publisher's website. TakedownIf you consider content in White Rose Research Online to be in breach of UK law, please notify us by emailing eprints@whiterose.ac.uk including the URL of the record and the reason for the withdrawal request.

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Epidemiology and clinical features of amyotrophic lateral sclerosis in Ireland between 1995 and 2004

Cited by 173 publications

References 11 publications

Changes in the Clinical Features of Amyotrophic Lateral Sclerosis in Rural Japan

Changes in the Clinical Features of Amyotrophic Lateral Sclerosis in Rural Japan

Emerging mechanisms of molecular pathology in ALS

Age-period-cohort analysis of trends in amyotrophic lateral sclerosis incidence

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