Primary or light chain (AL) amyloidosis is the most common form of amyloidosis and is characterized by a clonal population of plasma cells that produce a monoclonal lambda or kappa-type light chain (LC).In some subjects, this chain is deposited as amyloid in the organs and tissues, giving rise to clinical manifestations such as proteinuria or nephrotic syndrome, restrictive cardiomyopathy, and hepatomegaly. Although considered a rare disease, recent data suggest that cardiac amyloidosis (CA) is underestimated as a cause of common heart diseases or syndromes. In AL amyloidosis, both the hematologic and organ responses after treatment are important to improve clinical outcome, especially if cardiac function improves, as this is one of the key aspects in the prognosis of AL amyloidosis. We present and review the case of a 67-year-old female patient who, through a workup for anemia and heart failure, was diagnosed with multiple myeloma and CA due to LC deposition.