Epidemiology and clinical outcome of lower respiratory tract infections by respiratory syncytial virus or parainfluenza virus type 3 in adults receiving treatment for either acute leukemia or severe aplastic anemia: a retrospective single center study

Bigliardi, Sara; Morselli, Monica; Potenza, Leonardo; Riva, Giovanni; Coluccio, Valeria; Maccaferri, Monica; Paolini, Ambra; Colaci, Elisabetta; Fantuzzi, Valeria; Soci, Francesco; Nasillo, Vincenzo; Messerotti, Andrea; Arletti, Laura; Pioli, Valeria; Lugli, Elisabetta; Gilioli, Andrea; Quadrelli, Chiara; Vallerini, Daniela; Barozzi, Patrizia; Lagreca, Ivana; Marasca, Roberto; Narni, Franco; Franceschini, Erica; Codeluppi, Mauro; Mussini, Cristina; Luppi, Mario; Forghieri, Fabio

doi:10.1007/s00277-015-2455-3

Cited by 5 publications

(8 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the infection in the chemotherapy induction period is the leading cause of death of patients, mainly because the chemotherapy induction period is long, and patients have to receive chemotherapy every week, so the bone marrow suppression is obvious and granulocyte deficiency lasts for a long time. Besides, the disease itself will damage the humoral immunity and cellular immunity, the patient's immunity is decreased, combined with a large number of side effects due to long-term application of chemotherapy drugs, so the normal mucosal barriers of digestive tract and respiratory tract will be damaged ( 9 – 10 ). AL patients are susceptible to the invasion of pathogenic bacteria, thus suffering from infection, mainly respiratory virus infection that frequently occurs in the lungs ( 11 ).…”

Section: Discussionmentioning

confidence: 99%

Risk factors and coping strategies of severe community-acquired pneumonia in chemotherapy induction period of acute leukemia

Duan

Zhang

2018

Oncol Lett

View full text Add to dashboard Cite

The risk factors and coping strategies of severe community-acquired pneumonia (SCAP) in chemotherapy induction period of acute leukemia were investigated. Eighty-six patients with CAP in chemotherapy induction period of acute leukemia in Dezhou Hospital from March 2014 to February 2017 were selected and divided into observation group (SCAP group, n=45) and control group (non-SCAP group, n=41) according to the acute physiology and chronic health evolution II (APACHE II) score. The blood, sputum, nasopharyngeal secretion and pleural effusion samples were collected from patients in both groups, and the samples were detected for pathogens, followed by the analysis of relevant factors. The dynamic changes in the sequential organ failure assessment (SOFA) score, procalcitonin (PCT), D-dimer (D-D) and C-reactive protein (CRP) levels in patients were observed before and after the corresponding treatment strategies were taken. The total distribution ratio of pathogens from high to low in the two groups was as follows: bacterium, virus, fungus, mycoplasma and chlamydia trachomatis; there was no significant difference between the two groups (P>0.05). Logistic regression analysis showed that the repeated infection (OR=3.315, P=0.005), multi-resistant bacterial infection (OR=1.915, P=0.008) and D-D (OR=1.936, P=0.009) were independent risk factors for SCAP (P<0.05). After different coping strategies were taken, the SOFA score, PCT, D-D and CRP levels in the two groups were significantly decreased, and they were obviously higher in observation group than those in control group (P<0.05). Repeated infection, D-D level and multi-resistant bacterial infection are the risk factors affecting the SCAP in chemotherapy induction period of acute leukemia. The coping strategies can effectively relieve the patient's condition, reduce the severity of disease and improve the survival rate of patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Risk factors and coping strategies of severe community-acquired pneumonia in chemotherapy induction period of acute leukemia

Duan

Zhang

2018

Oncol Lett

View full text Add to dashboard Cite

show abstract

“…Design of the majority of studies was judged cross-sectional (54%; 19/35) or surveillance (29%; 10/35) and the median sample size was 328 (range 43–28,500) patients. The study population was composed of outpatients, inpatients and mixed groups in 20% (7/35), 37% (13/35) and 31% (11/35) of studies respectively; the remaining four (11%) studies were focused on hematological [43–45] and cystic fibrosis [57] in-/outpatients. The setting of these latter four studies was therefore categorized as “immunocompromised patients”.…”

Section: Resultsmentioning

confidence: 99%

“…The entire study selection process is reported in Fig 1. Most (83%; 29/35) studies included were full-length articles, while the remaining six were conference abstracts [45,47], letters to editor [43,57] and short papers [31,39] [43][44][45] and cystic fibrosis [57] in-/outpatients. The setting of these latter four studies was therefore categorized as "immunocompromised patients".…”

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

Epidemiology and burden of respiratory syncytial virus in Italian adults: A systematic review and meta-analysis

Domnich,

Calabrò

2024

Preprint

View full text Add to dashboard Cite

Objective Respiratory syncytial virus (RSV) is a common respiratory pathogen not only in children, but also in adults. Country-specific data on the epidemiology and burden of disease are essential for policy decisions. In view of a recent authorization of adult RSV vaccines, we aimed to comprehensively collect and assess evidence on the epidemiology and burden of RSV in Italian adults. Methods A systematic literature review was conducted according to the available guidelines. Random-effects proportional meta-analysis was performed to obtain pooled estimates and the observed heterogeneity was investigated by using both subgroup and meta-regression analyses. Results A total of 35 studies were identified. RSV seasonal attack rates ranged from 0.8 ‰ in community-dwelling older adults to 10.9% in hematological outpatients. On average, 4.5% (95% CI: 3.2-5.9%) of respiratory samples tested positive for RSV. This positivity prevalence was higher in older adults (4.4%; 95% CI: 2.8-6.3%) than in working-age adults (3.5%; 95% CI: 2.5-4.6%) and in outpatient (4.9%; 95% CI: 3.1-7.0%) than inpatient (2.9%; 95% CI: 1.5-4.8%) settings. Study location and sample size were also significant predictors of RSV detection frequency. The pooled estimate of in-hospital mortality was as high as 7.2% (95% CI: 4.7-10.3%). However, other important indicators of the diseases burden, such as complication and hospitalization rates, are missing. Conclusion RSV poses a measurable burden on Italian adults, especially those of older age and with some co-morbidities. Policy makers should give priority to health technology assessment of the novel RSV vaccines.

show abstract

“…The incidence rate of RSV infection in adult and pediatric hematologic subjects ranges between 1 and 50% (Table 1) [6]. This value ranges between 1 and 12% taking into account only adults [20] (Table 2). Although the mortality rate for pneumonia in healthy children and adults is low (0.5%), this A airborne precautions, C contact precautions, D droplet precautions, S standard precautions can reach 60% in immunocompromised untreated children and adults [17].…”

Section: Respiratory Syncytial Virus (Rsv)mentioning

confidence: 99%

“…Fontana and Strasfeld estimate that its incidence varies between 3 and 27% in patients with hematological malignancy and/or HSCT [6]. In adults, PiV incidence ranges between 2 and 7% [20].…”

Section: Parainfluenza Virus (Piv)mentioning

confidence: 99%

Viral Respiratory Infections in Hematological Patients

et al. 2020

View full text Add to dashboard Cite

Viral infections of the respiratory system represent one of the most important complications in hematological patients in terms of both the severity of the clinical picture and its related impact on the duration of hospitalization, and of mortality. The most implicated viruses are those that commonly cause community-based respiratory diseases: respiratory syncytial virus, Influenza virus and rhinovirus. However, in some cases the clinical picture may be triggered by first infection with or reactivation of pathogens normally not responsible for clinically relevant diseases in immunocompetent subjects. This issue is currently being taken into Enhanced Digital Features To view digital features for this article go to https://doi.org/10.6084/m9.figshare. 12497915.

show abstract

Epidemiology and clinical outcome of lower respiratory tract infections by respiratory syncytial virus or parainfluenza virus type 3 in adults receiving treatment for either acute leukemia or severe aplastic anemia: a retrospective single center study

Abstract: Epidemiology and clinical outcome of lower respiratory tract infections by respiratory syncytial virus or parainfluenza virus type 3 in adults receiving treatment for either acute leukemia or severe aplastic anemia: a retrospective single center stud

Cited by 5 publications

References 8 publications

Risk factors and coping strategies of severe community-acquired pneumonia in chemotherapy induction period of acute leukemia

Risk factors and coping strategies of severe community-acquired pneumonia in chemotherapy induction period of acute leukemia

Epidemiology and burden of respiratory syncytial virus in Italian adults: A systematic review and meta-analysis

Viral Respiratory Infections in Hematological Patients

Contact Info

Product

Resources

About