Epidemiology and Comorbidities of Bullous Pemphigoid: A Retrospective Study

Aşkın, Özge; Özkoca, Defne; Uzunçakmak, Tuğba Kevser Üstünbaş; Mat, Cem; Kutlubay, Zekayi

doi:10.4274/jtad.galenos.2020.68552

Cited by 4 publications

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“…Starenje predstavlja bitan faktor rizika za razvoj hroničnih bolesti, naročito kardiovaskularnih, karcinoma, dijabetesa, neuroloških, psihijatrijskih i drugih (6). Incidencija BP se naglo povećava sa godinama, naročito od 6. do 8. decenije, češće kod žena (7). Mehanizam patogeneze bolesti, kao i terapijski modaliteti koji se primenjuju u lečenju pemfigoida, mogu uticati na razvoj drugih hroničnih bolesti (8)(9)(10).…”

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“…S druge strane, terapija velikog broja hroničnih bolesti može da bude razlog nastajanja oblika pemfigoida izazvanog lekovima ili njegovog pogoršanja (11). U dosadašnjim radovima najčešći komorbiditeti koji su pratili BP bile su bolesti srca, hipertenzija, dijabetes melitus, neurološke i psihijatrijske bolesti (7,9,10).…”

Section: Uvodunclassified

“…U našem istraživanju je bilo 25% pacijenata koji su imali neku od psihijatrijskih dijagnoza, bez značajne razlike između polova. U literaturi postoje radovi koji su pokazali povezanost između buloznog pemfigoida i psihijatrijskih bolesti (19)(20)(21), dok je u istraživanju vršenom na Turskoj populaciji od 58 pacijenata (7) nađen samo jedan pacijent sa psihijatrijskom dijagnozom (1,72%).…”

Section: Diskusijaunclassified

“…Sa ishemijskom bolešću srca bilo je 12,5% ispitanika, statistički više žena. Slično istraživanje sprovedeno u Turskoj, pokazlo je da 26% pacijenata boluje od ishemijske bolesti srca (7). Međutim, neke studije koje ispituju povezanost ishemijske bolesti srca i BP došle su do rezultata da nije postojalo statistički značajno povećanje u odnosu na kontrolnu grupu, i pored toga što postoji teorijska povezanost u smislu hiperkoagulabilnosti u inflamatornim stanjima, kakvo je i BP (27,28).…”

Section: Diskusijaunclassified

“…Ispitanika sa BP i oboljenjem iz grupe bubrežnih bolesti bilo je 8,75%, bez statističke značajnosti između polova. Drugi radovi takođe prijavljuju značajan broj bolesnika sa bubrežnim komorbiditetima (7,18), samostalno, kao i u odnosu na opštu populaciju. U literaturi se pojavljuju i pojedinačno ispitani slučajevi nefroloških oboljenja povezanih sa BP (29,30).…”

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Epidemiology and comorbidities in bullous pemphigoid in the period from January of 2019 to the January of 2021

Radičević,

Minić

2022

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Introduction: Bullous pemphigoid is an autoimmune bullous dermatosis that most commonly occurs in elderly patients. Due to its pathogenesis and treatment of the disease, it can also affect the development of comorbidities. Aim: Determination of comorbidities and their frequency in patients with bullous pemphigoid, as well as their distribution by sex and the estimation of the duration of dermatosis from the onset of symptoms to data collection. Material and methods: In the period from January 2019 to January 2021, a number of 80 patients was analyzed. Basic patient data (age, sex, time of illness) and data on accompanying comorbidities were obtained. Data were categorized based on the ICD-10 classification into groups of diseases, as well as individual diseases that occurred frequently in the population. Results: Of the total number of respondents, 41.3% were male and 58.8% female. The average age of the respondents was 75.8 years, 76.45 years for men and 75.36 years for women. The period from the onset of symptoms to data collection was 3 months, while the average age of the disease in all subjects was 74.4 years. The most common comorbidities were hypertension 73.75%, psychiatric diseases 25%, type 2 diabetes mellitus 25%, other skin diseases 21.25%, urinary tract disorders 18.75%, ischemic heart disease 12.5%, type 1 diabetes mellitus 10%, kidney disease 8.75%, neurological disease 6.25%. Comorbidities were statistically more common in female patients: hypertension, ischemic heart disease, skin diseases and type 2 diabetes mellitus. Conclusion: In our study, bullous pemphigoid is confirmed the disease is of the elderly, predominantly female. Female patients suffer from some comorbidities more often. The period from the onset of symptoms to the collection of data is about 3 months. It is also showed that there are a number of comorbidities in the studied pemphigoid population, however, a large number of studies are needed to determine their association.

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Epidemiology and comorbidities in bullous pemphigoid in the period from January of 2019 to the January of 2021

Radičević,

Minić

2022

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Worldwide epidemiologic factors in pemphigus vulgaris and bullous pemphigoid

et al. 2023

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Autoimmune blistering diseases such as bullous pemphigoid (BP) and pemphigus vulgaris (PV) are complex, multifactorial, and polygenic diseases, whose exact pathogenesis is difficult to pinpoint. Research aimed at elucidating the associated epidemiologic risk factors of these two diseases has been hampered by their rare disease status. Further, a lack of centralization and standardization of available data makes the practical application of this information challenging. In order to collate and clarify the available literature we comprehensively reviewed 61 PV articles from 37 different countries and 35 BP articles from 16 different countries addressing a range of disease relevant clinical parameters including age of onset, sex, incidence, prevalence, and HLA allele association. The reported incidence of PV ranged from 0.098 to 5 patients per 100,000 people, while BP ranged from 0.21 to 7.63 patients per 100,000. Prevalence of PV ranged from 0.38 to 30 per 100,000 people and BP ranged from 1.46 to 47.99 per 100,000. The mean age of onset in patients ranged from 36.5 to 71 years for PV and 64 to 82.6 years for BP. Female-to-male ratios ranged from 0.46 to 4.4 in PV and 1.01 to 5.1 in BP. Our analysis provides support for the reported linkage disequilibrium of HLA DRB1*0402 (an allele previously shown to be associated with PV) and DQB1*0302 alleles in Europe, North America, and South America. Our data also highlight that HLA DQB1*0503 (also known to be associated with PV) appears in linkage disequilibrium with DRB1*1404 and DRB1*1401, mainly in Europe, the Middle East, and Asian countries. The HLA DRB1*0804 allele was only associated with PV in patients of Brazilian and Egyptian descent. Only two HLA alleles were reported as associated with BP more than twice in our review, DQB1*0301 and DQA1*0505. Collectively, our findings provide detailed insights into the variation of disease parameters relevant to PV and BP that can be expected to inform future work aimed at unraveling the complex pathogenesis of these conditions across the globe.

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Histopathological Spectrum and Role of Clinicopathological Correlation in Vesiculobullous Lesions - A Tertiary Care Hospital Experience

Khursheed

Shah

Ijaz

et al. 2022

J Ayub Med Coll Abbottabad

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Background: Histopathology is an important diagnostic modality for vesiculobullous lesions, however the diagnosis may at times require use of Immunofluorescence techniques which are expensive and not widely available. The aim of this study was to determine the histopathological spectrum of vesiculobullous diseases and to determine the role of clinic-pathological correlation in diagnosing bullous lesions. Methods: This was cross sectional validation study conducted in a tertiary care hospital, over a period of 18 months. All the clinically diagnosed cases of bullous diseases were included and examined as histological sections by three histopathologists. Results: Out of 58 total cases, the most frequently diagnosed lesions included Pemphigus vulgaris (27%), Bullous pemphigoid (13.8%) and Pemphigus foliaceous (12.1%). Females comprised 55% of cases, age distribution was wide but most patient were in age bracket of 20–39 years. Conclusion: There was 89.6% correlation between clinical and histopathological diagnosis. Only 2 cases were sent for Immunofluorescence studies, as histopathology was inconclusive in those cases. Therefore, we conclude that histopathological examination along with clinical correlation is a very useful way of diagnosing vesiculobullous disorders

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Epidemiology and Comorbidities of Bullous Pemphigoid: A Retrospective Study

Cited by 4 publications

References 0 publications

Epidemiology and comorbidities in bullous pemphigoid in the period from January of 2019 to the January of 2021

Epidemiology and comorbidities in bullous pemphigoid in the period from January of 2019 to the January of 2021

Worldwide epidemiologic factors in pemphigus vulgaris and bullous pemphigoid

Histopathological Spectrum and Role of Clinicopathological Correlation in Vesiculobullous Lesions - A Tertiary Care Hospital Experience

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