Epidemiology and costs of dengue in Brazil: a systematic literature review

Siqueira, João Bosco; Massad, Eduardo; Lobao-Neto, Abner; Kastner, Randee; Oliver, Louisa; Gallagher, Elaine

doi:10.1016/j.ijid.2022.06.050

Cited by 45 publications

(34 citation statements)

References 59 publications

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“…In these patients, hematocrit, platelet count, coagulation times (PT, PTT), DHL, and transaminases (ALT, AST) should be determined. In this phase, it is indicated to take serology to try to identify the serotype [10,19,20].…”

Section: Treatmentmentioning

confidence: 99%

“…The geographical and climatic conditions are not going to favor its spread, especially in communities where dengue fever is not endemic, however, it must not be forgotten that with changes in global climate conditions, the conditions for its spread can occur. Of dengue, as well as the appearance of different serotypes in regions where it is not common to find them [20].…”

Section: Treatmentmentioning

confidence: 99%

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Dengue Fever in Pediatrics

Romero¹,

Martinez²,

Martinez³

et al. 2023

Infectious Diseases

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Dengue continues to be a health problem in the world, according to data from the PAHO. In recent years, dengue cases have been reported from 505,430 cases in the year 2000 to 5.2 million in the year 2019; among the most affected groups are those under 15 years of age. Dengue is a viral disease caused by a virus of the Flaviviridae family, of the Flavivirus genus. It is a disease that requires the bite of the female Aedes aegypti mosquito; the incubation period varies from 8 to 12 days. The pathophysiology of dengue is due to the alterations suffered by the endothelium when caused by the viral particle. Three phases have been identified: 1. the febrile phase; 2. the critical phase, in which patients develop systemic symptoms with a greater inflammatory response, with a risk of bleeding; and 3. the recovery phase. The main symptoms are fever, headache, retro-ocular pain, arthralgia, myalgia, and within the laboratory alterations are elevated hematocrit (hemoconcentration), leukopenia, and thrombocytopenia, among the complications, are pleural and pericardial effusion and ascites, as well like crash and death.

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Section: Treatmentmentioning

confidence: 99%

Section: Treatmentmentioning

confidence: 99%

Dengue Fever in Pediatrics

Romero¹,

Martinez²,

Martinez³

et al. 2023

Infectious Diseases

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Section: Introductionmentioning

confidence: 99%

“…2 Brazil, the largest country in South America, is experiencing increased dengue incidence, with over 1.5 million cases reported in 2019. 3 A complex mixture of demographic and socio-economic factors influences the distribution and transmission of dengue, 4 which include inadequate living conditions, immunologically naïve populations, global trade and population mobility, climate change, and the adaptive nature of the principal mosquito vectors Aedes aegypti and Aedes albopictus. [5][6][7][8] Given that dengue vaccines are not suitable nor available for all dengue-endemic countries and anti-viral medications are not available, control of the mosquito vectors and reducing humanvector contact are recognized as the primary strategies for dengue prevention.…”

Section: Introductionmentioning

confidence: 99%

“…Household adult respondents' education level of elementary school or higher was negatively associated with children's relative risk of being seropositive (RR: 0.65, 95% CI: 0.49-0.87, p=0.004). The risk of seropositivity in older children (6-12 years old) was over 6 times that of younger children (2)(3)(4)(5) years old) (RR: 6.15, 95% CI: 3.51-10.76, p<0.001). Children living in households with sealed water tanks or no water storage had a lower relative risk of being seropositive (RR: 0.73, 95% CI: 0.55-0.99, p=0.041).…”

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confidence: 97%

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Knowledge, attitude and practice (KAP) and risk factors on dengue fever among children in Brazil, Fortaleza: A cross-sectional study

Zhang

Zahreddine

Abreu

et al. 2023

Preprint

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Background Dengue fever is a mosquito-borne viral disease that is associated with four serotypes of the dengue virus. Children are vulnerable to infection with the dengue virus and the risk of severe dengue disease is the highest among infants and children, particularly those who have been previously infected with a different dengue serotype. Sufficient knowledge, positive attitudes, and proper practices (KAP) are essential for dengue prevention and control. This study aims to estimate the dengue seropositivity for study participants and to examine the association between households’ dengue-related knowledge, attitudes, and practices (KAP), and children’s risk of dengue seropositivity, while accounting for socioeconomic and demographic differences in Brazil. Methodology/Principal Findings This analysis was based on a cross-sectional study from Fortaleza, Brazil between November 2019, and February 2020. There were 392 households and 483 participant children who provided a sample of sufficient quality for serological analysis. The main exposure was a household’s dengue-related knowledge, attitudes, and practices, assessed through a questionnaire to construct a composite KAP score categorized into three levels: low, moderate and high. The main outcome is dengue immunoglobulin G(IgG) antibodies, collected using dried blood spots and assessed with Panbio Dengue IgG indirect ELISA (enzyme-linked immunosorbent assays) test commercial kits. The estimated crude dengue seroprevalence among participating children (n=483) was 25.1%. 5% (n=20) of households achieved a score of over 75% for KAP, while most households achieved between 50% and 75% of the total scores (n=271, 69%), and 101 households scored lower than 50% of the total score (26%). Each KAP domain was significantly and positively associated with the others. We found high household KAP scores were associated with an increased risk of seropositivity (RR: 2.08, 95% CI: 1.09-3.97, p=0.027). Household adult respondents’ education level of elementary school or higher was negatively associated with children’s relative risk of being seropositive (RR: 0.65, 95% CI: 0.49-0.87, p=0.004). The risk of seropositivity in older children (6-12 years old) was over 6 times that of younger children (2-5 years old) (RR: 6.15, 95% CI: 3.51-10.76, p<0.001). Children living in households with sealed water tanks or no water storage had a lower relative risk of being seropositive (RR: 0.73, 95% CI: 0.55-0.99, p=0.041). Conclusions/Significance Our results provide insight into the prevalence of dengue seropositivity in Fortaleza, Brazil in children, and certain demographic and socioeconomic characteristics associated with children’s risk of being seropositive. They also suggest that KAP may not identify those more at risk for dengue, although understanding and enhancing households’ KAP is crucial for effective community dengue control and prevention initiatives.

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Upsurge of dengue outbreaks in several WHO regions: Public awareness, vector control activities, and international collaborations are key to prevent spread

Sarker,

Roknuzzaman,

Haque

et al. 2024

Health Science Reports

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BackgroundDengue, the world's fastest‐growing vector‐borne disease, has skyrocketed in the 21st century. Dengue has harmed human health since its first known cases among Spanish soldiers in the Philippines to its 21st‐century outbreaks in Southeast Asia, the Pacific, and the Americas. In light of the current circumstances, it is imperative to investigate its origin and prevalence, enabling the implementation of effective interventions to curb the upsurge.MethodsOur study examines the history of dengue outbreaks, and evolving impact on public health, aiming to offer valuable insights for a more resilient public health response worldwide. In this comprehensive review, we incorporated data from renowned databases such as PubMed, Google Scholar, and Scopus to provide a thorough analysis of dengue outbreaks.ResultsRecent dengue outbreaks are associated with rapid urbanization, international travel, climatic change, and socioeconomic factors. Rapid urbanization and poor urban design and sanitation have created mosquito breeding places for dengue vectors. Also, international travel and trade have spread the pathogen. Climate change in the past two decades has favored mosquito habitats and outbreaks. Socioeconomic differences have also amplified the impact of dengue outbreaks on vulnerable communities. Dengue mitigation requires vector control, community engagement, healthcare strengthening, and international cooperation.ConclusionClimate change adaptation and urban planning are crucial. Although problems remain, a comprehensive vector control and community involvement plan may reduce dengue epidemics and improve public health in our interconnected world.

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Epidemiology and costs of dengue in Brazil: a systematic literature review

Cited by 45 publications

References 59 publications

Dengue Fever in Pediatrics

Dengue Fever in Pediatrics

Knowledge, attitude and practice (KAP) and risk factors on dengue fever among children in Brazil, Fortaleza: A cross-sectional study

Upsurge of dengue outbreaks in several WHO regions: Public awareness, vector control activities, and international collaborations are key to prevent spread

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