Epidemiology and distribution of interstitial lung diseases in <scp>T</scp>urkey

Müsellim, Benan; Okumuş, Gülfer; Uzaslan, Esra; Akgün, Metin; Çetınkaya, Erdoğan; Turan, Onur; Akkoçlu, Atila; Armagan, Hazar; Köktürk, Nurdan; Çalişir, Haluk C.

doi:10.1111/crj.12035

Cited by 63 publications

(59 citation statements)

References 14 publications

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“…Overall, the crude prevalence of ILDs in our study is even greater than that reported by COULTAS (67-81 per 100000 in the US) [1] and the incidence is close to the highest estimates (25.8 per 100000 per year in Turkey) [4]. Two original findings are of particular interest.…”

Section: Discussionsupporting

confidence: 64%

“…Interstitial lung diseases (ILDs) form a heterogeneous group of disorders that comprise more than 200 entities commonly encountered by general practitioners and physicians of various specialties [1][2][3][4]. ILDs are classically divided into four categories: (i) ILDs of known causes, e.g.…”

Section: Introductionmentioning

confidence: 99%

“…The existing publications show wide ranges in the prevalence and incidence of the various ILDs between countries [1][2][3][4]13]. These disparities may reflect methodological differences or true genetic or demographic specificities, since the frequency of the majority of ILDs is influenced by age, gender, ethnicity, and smoking habits [14].…”

Section: Introductionmentioning

confidence: 99%

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Prevalence and incidence of interstitial lung diseases in a multi-ethnic county of Greater Paris

et al. 2017

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The objective of the study was to estimate the prevalence and incidence of interstitial lung diseases (ILDs) in Seine-Saint-Denis, a multi-ethnic county of Greater Paris, France.Patients with ILDs were identified between January and December 2012 by using several sources; all potentially involved medical specialists from public and private hospitals, community-based pulmonologists and general practitioners, and the Social Security system. Diagnoses were validated centrally by an expert multidisciplinary discussion.1170 ILD cases were reported (crude overall prevalence: 97.9/105and incidence: 19.4/105/year). In the 848 reviewed cases, the most prevalent diagnoses were sarcoidosis (42.6%), connective tissue diseases associated ILDs (CTDs-ILDs) (16%), idiopathic pulmonary fibrosis (IPF) (11.6%), and occupational ILDs (5.0%), which corresponded to a crude prevalence of 30.2/105for sarcoidosis, 12.1/105for CTDs-ILDs and 8.2/105for IPF. The prevalence of fibrotic idiopathic interstitial pneumonias, merging IPF, nonspecific interstitial pneumonia and cases registered with code J84.1 was 16.34/105. An adjusted multinomial model demonstrated an increased risk of sarcoidosis in North Africans and Afro-Caribbeans and of CTDs-ILDs in Afro-Caribbeans, compared to that in Europeans.This study, with a comprehensive recruitment and stringent diagnostic criteria, emphasises the importance of secondary ILDs, particularly CTDs-ILDs and the relatively low prevalence of IPF, and confirms that sarcoidosis is a rare disease in France.

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Section: Discussionsupporting

confidence: 64%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Prevalence and incidence of interstitial lung diseases in a multi-ethnic county of Greater Paris

et al. 2017

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“…In another study that included 30 cases ≥65 years and 70 younger subjects, the ratio of female patients was found to be significantly higher in the older group (83.3% vs 50%) [5]. A multicenter Turkish study reported that sarcoidosis was the most common interstitial disease; 53% were female and 75% were ≤50 years old [13]. The most comprehensive epidemiological research in Turkey included 293 patients with sarcoidosis and was published in 2009.…”

Section: Discussionmentioning

confidence: 99%

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2017

Eurasian J Med

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Objective: While the incidence of sarcoidosis peaks between 20 and 39 years, it is comparatively low in elderly subjects. We sought to determine whether there are age-dependent differences in the demographic and laboratory characteristics of patients with sarcoidosis. Materials and Methods: We retrospectively collected information from our database using the International Classification of Disease (ICD) diagnostic code D86 between 2008 and 2014. Patients were divided into three groups: 20-39 years old (Group 1), 40-59 years old (Group 2), and 60-80 years old (Group 3). Results: A total of 3988 patients with code of D86 were included in the study. After the exclusion of noneligible patients, the number of cases in Groups 1, 2, and 3 were 276, 641, and 352, respectively. The groups were compared according to demographic characteristics, ICD diagnostic codes, and laboratory parameters. The ratio of female patients was significantly higher in Group 3 than in Groups 1 and 2 (p=0.000). There was no difference in diagnostic codes of the ICD subgroups between groups (p=0.19). While the level of bloodurea nitrogen was significantly higher in Group 3 patients than in other groups (p=0.000), serum angiotensinconverting enzyme (ACE) values were found to be significantly low in Group 3 (p=0.010). The mean ACE values did not differ between females and males (50.8±39.3 and 59.1±45.5 mg/dL, respectively) (p=0.18). Conclusion:The majority of patients with sarcoidosis were female in all age groups and pulmonary sarcoidosis was the most common presentation of the disease. Elderly patients (≥60 years) with sarcoidosis had lower serum ACE levels than younger patients.

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“…Previous studies have revealed that ILDs are more common in males, but CTD-ILDs are more common in females (22)(23)(24)(25)(26). Females are also prone to other autoimmune diseases as well (6,15,27,28).…”

Section: Discussionmentioning

confidence: 99%

Interstitial Lung Diseases in Rheumatology Practice: A Single Center Experience

Erbasan¹,

Öygen²,

Gök³

et al. 2017

Akd Med J

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Objective: Interstitial lung diseases (ILDs) are a heterogeneous group of pulmonary diseases affecting the pulmonary interstitium. ILDs may occur secondary to connective tissue diseases (CTDs) and increase morbidity and mortality due to ventilation impairment. The aim of this study was to reveal the clinical, laboratory and imaging features of CTD-related ILDs (CTD-ILDs) and to analyze the treatment approaches. Material and Methods:A total of 132 consecutive ILD patients were included in this cohort. Demographic characteristics, laboratory and high-resolution chest computed tomography (HRCT) results and treatments were analyzed. results: There were 99 patients with CTD-ILD, the mean age was 54.7±11.6 years, females made up 82.8%, median follow-up time was 48.5 months. There were 96 patients who were followed up for more than six months. The median number of HRCT scans was 3 (1-10) with a median interval of 12.5 months. Most common HRCT findings were ground-glass opacities and interlobular septal thickening. One-third of all scans had a honeycomb pattern. 89.6% of CTD-ILD patients recieved corticosteroids, and 44.8% recieved antimalarials. Azathioprine and cyclophosphamide were the most commonly used immunosuppressive drugs. After treatment, the mean pulmonary function tests did not significantly differ from the baseline (p >0.05). 35% of the patients had improved forced vital capacity (FVC >10% increase) with treatment whereas 31% had decreased values and 34% were stable. conclusion:The desired point of the treatment of CTD-ILD patients has not been reached yet even though a significant effort is being made for the diagnosis, treatment and follow up. Novel curative agents are needed for patients with CTD-ILD.Key Words: Connective tissue diseases, High-resolution computed tomography, Interstitial lung diseases. ÖZAmaç: İnterstitiel akciğer hastalığı(İAH) akciğerlerdeki interstitiel aralığı etkileyen heterojen bir hastalık grubudur. İAH bağ doku hastalıklarına(BDH) sekonder gelişebilir ve solunum yetmezliğinden dolayı sakatlık ve ölüm oranı artar. Bu çalışmanın amacı BDH ilişkili İAH'nın klinik, laboratuvar ve görüntüleme özelliklerini tanımlamak ve tedavi yaklaşımlarını analiz etmektir. Gereç ve Yöntemler:Bu çalışmaya ardışık gelen 132 İAH hastası alındı. Demografik özellikleri, laboratuvar ve yüksek rezolüsyonlu akciğer tomografisi(HRCT) ve tedavi sonuçları analiz edildi. bulgular: BDH ilişkili İAH tanısı alan 99 hasta vardı. Ortalama yaş 54.7±11.6 yıl, kadın oranı %82.8, median takip süresi 48.5 aydı. 96 hastanın takip süresi altı aydan fazlaydı. HRCT taramaları median 12.5 aylık intervaller ile median 3(1-10) kez tekrarlanmıştı. En sık HRCT bulguları buzlu cam opasiteleri ve interlobüler septal kalınlaşmalardır. Hastaların üçte birinde bal peteği paterni vardı. Hastaların %89.6'sı kortikosteroid %44.8'i antimalaryal ajan almıştı. Azatiopürin ve siklofosfamid en sık kullanılan immünosupresif ilaçlardı. Tedavi sonrası ortalama solunum fonksiyon testleri tedavi

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Epidemiology and distribution of interstitial lung diseases in Turkey

Abstract: The overall incidence of ILD in Turkey was computed to be 25.8/100,000.

Cited by 63 publications

References 14 publications

Prevalence and incidence of interstitial lung diseases in a multi-ethnic county of Greater Paris

Prevalence and incidence of interstitial lung diseases in a multi-ethnic county of Greater Paris

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Interstitial Lung Diseases in Rheumatology Practice: A Single Center Experience

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