Epidemiology and economic burden of measles, mumps, pertussis, and varicella in Germany: a systematic review

Damm, Oliver; Witte, J.; Wetzka, S.; Prosser, Christine; Braun, Sebastian; Welte, R; Greiner, Wolfgang

doi:10.1007/s00038-016-0842-8

Cited by 33 publications

(16 citation statements)

References 56 publications

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“…A recent literature review summarized the annual societal costs of varicella in the prevaccination era at 187.5 million euros, of which 18% were direct medical costs [46]. Hospitalizations due to (severe) varicella complications are the main contributors to the direct medical costs of varicella [47].…”

Section: Discussionmentioning

confidence: 99%

Specific Varicella-Related Complications and Their Decrease in Hospitalized Children after the Introduction of General Varicella Vaccination: Results from a Multicenter Pediatric Hospital Surveillance Study in Bavaria (Germany)

Hagemann

Krämer

Grote³

et al. 2019

Infect Dis Ther

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Background: Universal varicella vaccination (UVV) for children introduced in Germany in 2004 resulted in a significant overall decline of varicella-related hospitalizations (VRHs). We investigated the incidence of specific types of varicella-related complications (VRCs) in hospitalized children and the impact of UVV on VRCs during the first 7 years of UVV. Methods: Children\ 17 years of age hospitalized with an ICD-10-based (International Classification of Diseases, 10th Revision) discharge Enhanced Digital Features To view enhanced digital features for this article go to https://doi.org/10.6084/ m9.figshare.9994730.

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Section: Discussionmentioning

confidence: 99%

Specific Varicella-Related Complications and Their Decrease in Hospitalized Children after the Introduction of General Varicella Vaccination: Results from a Multicenter Pediatric Hospital Surveillance Study in Bavaria (Germany)

Hagemann

Krämer

Grote³

et al. 2019

Infect Dis Ther

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“…The disease remains a killer among vaccine-preventable diseases, especially among children of developing countries [34, 35]. Additionally, a recent systematic review of the epidemiologic and economic burden of measles, mumps, pertussis and varicella in Germany suggested that there was still considerable morbidity due to childhood diseases [36]. The present study estimation of a significant indirect cost associated with measles-related deaths may be a clear pointer that the disease continues to affect Somalia, especially among children 14 years and younger, robbing off their future productivity and contributions to society.…”

Section: Discussionmentioning

confidence: 99%

Indirect costs associated with deaths of children aged 0–14 years from measles in a weak health system and conflict and fragile zone: the case of Somalia

Da’ar

2019

Epidemiol. Infect.

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This study recognises periodic outbreaks of measles continue to affect conflict and fragile zones in the least developed countries. This study set out to provide evidence for the indirect costs or economic loss associated with measles-related deaths among children aged 0–14 years in Somalia. Using epidemiologic and economic data, the indirect cost was calculated based on the framework of the World Health Organisation guide of identifying the economic consequences of disease and injury. The baseline indirect cost was computed as the product of discounted future productive years of life lost (PYLL), non-health gross domestic product per capita (NHGDPPC) and the estimated total measles deaths (ETMD). The model was adjusted for conflict and fragility conditions and further extension considered a finite and stable upper limit growth of the instability-adjusted NHGDPPC. To discount future costs, a rate of 3% was applied. Using a ±20% variability assumption of the epidemiologic and economic factor inputs, a sensitivity analysis was conducted to account for uncertainty. In 2015 values, the ETMD of 3723 measles deaths of children aged 0–14 years could decrease non-health GDP of the country by $23.46 million, a potential loss of $6303 per death over the discounted PYLL. The loss would increase by 5.3% when adjusted for conflict and fragility conditions. Assuming growth, the future adjusted loss is expected to be $35.91 million in 2015 values. Girl-child deaths accounted for 51.2% of the burden. Results are robust to the variations in the model inputs, although sensitivity analyses suggest the proportion of total measles deaths and the discount rate accounted for greater uncertainty of the loss than do the proportion of growth and instability assumption. Conflict and fragility accounted for the least uncertainty, perhaps confirming their relative perpetuity in Somalia. Results show significant indirect cost related to measles deaths of children, exacerbated by conflict and fragility. This is an economic burden, but one which the health system, policy-makers, government and other stakeholders should be prepared to colossally discount by collectively taking measles surveillance and security measures now to reduce further deaths in the future.

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“…Socioeconomic factors seemed to play a major role in vaccination compliance [17], while contracting measles has been itself associated with a significant economic burden [18].…”

Section: Epidemiology Of Measles and Mumps In Lebanonmentioning

confidence: 99%

Measles and Mumps Outbreaks in Lebanon : Trends and Links

Kassir

Bizri

Kassir

et al. 2020

Preprint

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Background: Lebanon has experienced several measles and mumps outbreaks in the past twenty years. In this article, a case-based surveillance of both measles and mumps outbreaks in Lebanon was carried out in an attempt to outline factors contributing to the failure of elimination plans and to provide potential solutions. The relationship between the outbreaks of both diseases was described and explored. Methods: A retrospective descriptive study of confirmed cases of measles and mumps in Lebanon between 2003 and 2018 collected from the Lebanese Ministry of Public Health Epidemiological Surveillance Unit public database was carried out. The information collected was graphically represented taking into consideration dates of reported cases, age groups affected, and vaccination status. Results: The mean number of measles cases was 150.25 cases/year in the 1-4 years age group, 87 cases/year in individuals aging between 5 and 14, and 63.68 cases/year in those > 14 years old. In the latter group, only 18.05% were unvaccinated. The mean number of mumps cases was 30.4 cases/year in the <4 year age group and 53.8 cases/year in the 10-19 years age group. During the study period, every spike in measles cases was followed by a similar spike in mumps. 9.66% of measles cases occurred in individuals who received at least 2 doses of the vaccine, 52.26% in the unvaccinated, and 38% in those whose vaccination status was undetermined. Conclusions: Measles in Lebanon is a disease of the pediatric population, but adults remain at risk. Outbreaks of mumps followed those of measles and were mainly among adolescents. Presence of a large number of Syrian refugees in the country may further complicate the situation. Vaccination activities need to be intensified.

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Epidemiology and economic burden of measles, mumps, pertussis, and varicella in Germany: a systematic review

Cited by 33 publications

References 56 publications

Specific Varicella-Related Complications and Their Decrease in Hospitalized Children after the Introduction of General Varicella Vaccination: Results from a Multicenter Pediatric Hospital Surveillance Study in Bavaria (Germany)

Specific Varicella-Related Complications and Their Decrease in Hospitalized Children after the Introduction of General Varicella Vaccination: Results from a Multicenter Pediatric Hospital Surveillance Study in Bavaria (Germany)

Indirect costs associated with deaths of children aged 0–14 years from measles in a weak health system and conflict and fragile zone: the case of Somalia

Measles and Mumps Outbreaks in Lebanon : Trends and Links

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